Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus

Gastroenterology

Volumn 115, Issue 6, 1998, Pages 1381-1386

  Klump, B ^a   Hsieh, C J ^a   Holzmann, K ^a   Gregor, M ^a   Porschen, R ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN P16;

ARTICLE; BARRETT ESOPHAGUS; CHROMOSOME 9P; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; ESOPHAGUS CARCINOMA; GENE INACTIVATION; HUMAN; HUMAN TISSUE; MALIGNANT TRANSFORMATION; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0031762798     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70016-2     Document Type: Article

References (40)

1. T Nobori K Miura DJ Wu A Lois K Takabayashi DA Carson Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers Nature 368 1994 753 756
2. M Serrano GJ Hannon D Beach A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK 4 Nature 366 1993 704 707
3. GJ Hannon D Beach p15INK4B is a potential effector of TGF-β-induced cell cycle arrest Nature 371 1994 257 261
4. A Kamb NA Gruis J Weaver-Feldhaus Q Liu K Harshman SV Tavtigian E Stockert RS Day BE Johnson MH Skolnick A cell cycle regulator potentially involved in genesis of many tumor types Science 246 1994 436 440
5. P Zhou W Jiang CM Weghorst IB Weinstein Overexpression of cyclin D1 enhances gene amplification Cancer Res 56 1996 36 39
6. CJ Sherr Cancer cell cycles Science 274 1996 1672 1677
7. DE Quelle F Zindy RA Ashmun CJ Sherr Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest Cell 83 1995 993 1000
8. ARF Cell 91 1997 649 659
9. MT Barrett CA Sanchez PC Galipeau K Neshat M Emond BJ Reid Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus Oncogene 13 1996 1867 1873
10. P Cairns TJ Polascik Y Eby K Tokino J Califano A Merlo L Mao J Herath R Jenkins W Westra J Rutter A Buckler E Gabrielson M Tockman KR Cho L Hedrick GS Bova W Isaacs W Koch D Schwab D Sidransky Frequency of homozygous deletion at p16/CDKN2 in primary human tumors Nat Genet 11 1995 210 212
11. T Mori K Miura T Aoki T Nishihira S Mori Y Nakamura Frequent somatic mutations of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma Cancer Res 54 1994 3396 3397
12. X Zhou L Tarmin J Yin HY Jiang H Suzuki MG Rhyu JM Abraham SJ Meltzer The MTS1 gene is frequently mutated in primary human esophageal tumors Oncogene 9 1994 3737 3741
13. H Igaki H Sasaki Y Tachimori H Kato H Watanabe T Kimura Y Harada T Sugimura M Terada Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract Cancer Res 203 1995 3421 3423
14. P Cairns L Mao A Merlo DJ Lee D Schwab Y Eby K Tokino P van der Riet JE Blaugrund D Sidransky Rates of p16 (MTS1) mutations in primary tumors with 9p loss Science 265 1994 415 416
15. INK4A promoter is hypermethylated at a high frequency in esophageal adenocarcinoma Cancer Res 57 1997 2619 2622
16. A Merlo JG Herman L Mao DJ Lee E Gabrielson PC Burger SB Baylin D Sidransky 5' CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers Nat Med 1 1995 686 692
17. JG Herman A Merlo L Mao RG Lapidus JP Issa NE Davidson D Sidransky SB Baylin Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers Cancer Res 55 1995 4525 4530
18. M Gonzalez-Zulueta CM Bender AS Yang T Nguyen RW Beart JM Van Tornout PA Jones Methylation of the 5'CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing Cancer Res 55 1995 4531 4535
19. SR Hamilton RRL Smith JL Cameron Prevalence and characteristics of Barrett's esophagus in patients with adenocarcinoma of the esophagus or esophagogastric junction Hum Pathol 19 1988 942 948
20. RW Phillips RKH Wong Barrett's esophagus: natural history, incidence, etiology and complications Gastroenterol Clin North Am 20 1991 791 816
21. WJ Blot SS Devesa RW Kneller JF Fraumeni Continuing climb in rates of esophageal adenocarcinoma: an update JAMA 270 1993 1320
22. RC Haggitt Barrett's esophagus, dysplasia and adenocarcinoma Hum Pathol 25 1994 982 993
23. RH Riddell H Goldman DF Ransohoff HD Appelmann CD Fenoglio RC Haggitt C Ahren P Correa SR Hamilton BC Morson SC Sommers JH Jarolley Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications Hum Pathol 14 1983 931 966
24. JG Herman JR Graff S Myöhänen B Nelkin SB Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 1996 9821 9826
25. MT Barrett PC Galipeau CA Sanchez MJ Emond BJ Reid Determination of the frequency of loss of heterozygosity in esophageal adenocarcinoma by cell sorting, whole genome amplification and microsatellite polymorphisms Oncogene 12 1996 1873 1878
26. H Suzuki X Zhou J Yin J Lei HY Jiang Y Suzuki T Chan GJ Hannon WJ Mergner JM Abraham SJ Meltzer Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers Hum Mol Genet 4 1995 1883 1887
27. J Jen W Harper SH Bigner DD Bigner N Papadopoulos S Markowitz JKV Wilson KW Kinzler B Vogelstein Deletion of p16 and p15 genes in brain tumors Cancer Res 54 1994 6353 6358
28. INK4B Cancer Res 56 1996 722 727
29. S Stone P Dayananth P Jiang JM Weaver-Geldhous SV Tavtigian L Cannon-Albright A Kamb Genomic structure, expression, and mutational analysis of the p15 (MTS2) gene Oncogene 11 1995 987 991
30. C Caldas SA Hahn LT da Costa MS Redston M Schutte AB Seymour CL Weinstein RH Hruban CJ Yeo SE Kern Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma Nat Genet 8 1994 27 32
31. N Ahuja AL Mohan Q Li JM Stolker JG Herman SR Hamilton SB Baylin J-PJ Issa Association between CpG island methylation and microsatellite instability in colorectal cancer Cancer Res 57 1997 3370 3374
32. J-P.J Issa YL Ottaviano P Celano SR Hamilton NE Davidson SB Baylin Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon Nat Genet 7 1994 536 540
33. J-PJ Issa PM Vertino CD Boehm IF Newsham SB Baylin Switch from mono-allelic to bi-allelic human IGF2 promoter methylation during aging and carcinogenesis Proc Natl Acad Sci USA 93 1996 11757 11762
34. JF Costello MS Berger HJ Huang WK Cavenee Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation Cancer Res 56 1996 2405 2410
35. M Schutte RH Hruban J Geradts R Maynard W Hilgers SK Rabindran CA Moskaluk SA Hahn I Schwarte-Waldhoff W Schmiegel SB Baylin SE Kern JG Herman Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas Cancer Res 57 1997 3126 3130
36. YX Hu H Watanabe K Ohtsubo Y Yamaguchi A Ha T Okai N Sawabu Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma Clin Cancer Res 3 1997 1473 1477
37. Waf1 genes are associated with aggressive variants of mantle cell lymphomas Blood 89 1997 272 280
38. JA Reed F Loganzo CR Shea GJ Walker JF Flores JM Glendening JK Bogdany MJ Shiel FG Haluska JW Fountain AP Albino Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression Cancer Res 55 1995 2713 2718
39. M Younes A Ertan LV Lechago JR Somoano J Lechago p53 accumulation is a specific marker of malignant potential in Barrett's metaplasia Dig Dis Sci 42 1997 697 701
40. W Hameetemann GNJ Tytgat HJ Houthoff JG van den Tweel Barrett's esophagus, development of dysplasia and adenocarcinoma Gastroenterology 96 1989 1249 1256