Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes

Experimental Dermatology

Volumn 14, Issue 7, 2005, Pages 519-527

  Shi, Biao ^a   Isseroff, R Rivakh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AP 1 cellular senescence; EGF; ERK; Human epidermal keratinocytes

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; DNA; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN FOS; PROTEIN KINASE C; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FRA 2;

ARTICLE; ATTENUATION; CELL ACTIVITY; CELL AGING; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS CELL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; INHIBITION KINETICS; KERATINOCYTE; NEWBORN; NORMAL HUMAN; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL AGING; CELLS, CULTURED; DNA; DNA-BINDING PROTEINS; EPIDERMAL GROWTH FACTOR; FOS-RELATED ANTIGEN-2; HUMANS; KERATINOCYTES; MAP KINASE SIGNALING SYSTEM; MITOGENS; PHOSPHORYLATION; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 21244464310     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0906-6705.2005.00317.x     Document Type: Article

References (58)

1. West M D. The cellular and molecular biology of skin aging. Arch Dermatol 1994: 130: 87-95.
2. Gilchrest B A. A review of skin ageing and its medical therapy. Br J Dermatol 1996: 135: 867-875.
3. Lober C W, Fenske N A. Cutaneous aging: effect of intrinsic changes on surgical considerations. South Med J 1991: 84: 1444-1446.
4. Nicolle L E, Huchcroft S A, Cruse P J E. Risk factors for surgical wound infection among the elderly. J Clin Epidemiol 1992: 45: 357-364.
5. Ashcroft G S, Mills S J, Ashworth J J. Ageing and wound healing. Biogerontology 2002: 3: 337-345.
6. Hayflick L, Moorehead P S. The serial cultivation of human diploid cell strains. Exp Cell Res 1961: 25: 585-621.
7. Von Zglinicki T. Replicative senescence and the art of counting. Exp Gerontol 2003: 38: 1259-1264.
8. Bird J, Ostler E L, Faragher R G A. Can we say senescent cells cause ageing? Exp Gerontol 2003: 38: 1319-1326.
9. Ben-Porath I, Weinberg R A. When cells get stressed: an integrative view of cellular senescence. J Clin Invest 2004: 113: 8-13.
10. Campisi J. The role of cellular senescence in skin aging. J Investig Dermatol Symp Proc 1998: 3: 1-5.
11. Gilchrest B A, Bohr V A. Aging processes, DNA damage, and repair. FASEB J 1997: 11: 322-330.
12. Shiraha H, Gupta K, Drabik K, Wells A. Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors. J Biol Chem 2000: 275: 19343-19351.
13. Yaar M, Gilchrest B A. Ageing and photoageing of keratinocytes and melanocytes. Clin Exp Dermatol 2001: 26: 583-591.
14. Campisi J. From cells to organisms: can we learn about aging from cells in culture? Exp Gerontol 2001: 36: 607-618.
15. Palmer H J, Tuzon C T, Paulson K E. Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases. J Biol Chem 1999: 274: 11424-11430.
16. Peacocke M, Yaar M, Gilchrest B A. Interferon and the epidermis: implications for cellular senescence. Exp Gerontol 1989: 24: 415-421.
17. Saunders N A, Smith R J, Jetten A M. Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells. Biochem Biophys Res Commun 1993: 197: 46-54.
18. Rheinwald J G, Green H. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 1977: 265: 421-424.
19. Park W Y, Park J S, Cho K A et al. Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem 2000: 275: 20847-20852.
20. Chung J H, Kang S, Varani J, Lin J, Fisher G J, Voorhees J J. Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo. J Invest Dermatol 2000: 115: 177-182.
21. Whitmarsh A J, Davis R J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 1996: 74: 589-607.
22. Young M R, Nair R, Bucheimer N et al. Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently. Mol Cell Biol 2002: 22: 587-598.
23. Riabowol K, Schiff J, Gilman M Z. Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc Natl Acad Sci USA 1992: 89: 157-161.
24. Lavrovsky Y, Chatterjee B, Clark R A, Roy A K. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 2000: 35: 521-532.
25. Rittie L, Fisher G J. UV-light-induced signal cascade and skin aging. Ageing Res Rev 2002: 1:705-720.
26. Ng D C, Shafaee S, Lee D, Bikle D D. Requirement of an AP-1 site in the calcium response region of the involucrin promoter. J Biol Chem 2000: 275: 24080-24088.
27. Medicherla R, Leers-Sucheta S, Luo Y, Azhar S. Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing. Mech Ageing Dev 2001: 122: 1169-1186.
28. Nickoloff B J, Chaturvedi V, Bacon P, Qin J Z, Denning M F, Diaz M O. Id-1 delays senescence but does not immortalize keratinocytes. J Biol Chem 2000: 275: 27501-27504.
29. Wang X, Bregegere F, Soroka Y, Kayat A, Redziniak G, Milner Y. Enhancement of Fas- mediated apoptosis in ageing human keratinocytes. Mech Ageing Dev 2004: 125: 237-249.
30. Dimri G P, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995: 92: 9363-9367.
31. Wong J W, Shi B, Farboud B et al. Ultraviolet B-mediated phosphorylation of the small heat shock protein HSP27 in human keratinocytes. J Invest Dermatol 2000: 115: 427-434.
32. Rosette C, Karin M. Cytoskeletal control of gene expression: depolymerization of microtubes activated NF-κB. J Cell Biol 1995: 128: 1111-1119.
33. Haas A F, Wong J W, Iwahashi C K, Halliwell B, Cross C E, Davis P A. Redox regulation of wound healing? NF-κB activation in cultured human keratinocytes upon wounding and the effect of low energy HeNe irradiation. Free Radic Biol Med 1998: 25: 998-1005.
34. 2- induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res 2004: 298: 188-196.
35. Bubulya A, Wise S C, Shen X Q, Burmeister L A, Shemshedini L. c-Jun can mediate androgen receptor-induced transactivation. J Biol Chem 1996: 271: 24583-24589.
36. Whisler R L, Chen M, Liu B, Carle K W. Impaired induction of c-fos/c-jun genes and of transcriptional regulatory protein binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. Cell Immunol 1997: 175: 41-50.
37. Stoscheck C M, Carpenter G. Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J Cell Biol 1984: 98: 1048-1053.
38. Tran K T, Rusu S D, Satish L, Wells A. Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity. Exp Cell Res 2003: 289: 359-367.
39. Rojas M, Yao S, Lin Y Z. Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor. J Biol Chem 1996: 271: 27456-27461.
40. Schmuth M, Elias P M, Hanley K et al. The effect of LXR activators on AP-1 proteins in keratinocytes. J Invest Dermatol 2004: 123: 41-48.
41. Rutberg S E, Saez E, Glick A, Dlugosz A A, Spiegelman B M, Yuspa S H. Differentiation of mouse keratinocytes is accompanied by PKC-dependent change in AP-1 proteins. Oncogene 1996: 13: 167-176.
42. Gagliardi M, Maynard S, Miyake T et al. Opposing roles of C/EBPβ and AP-1 in the control of fibroblast proliferation and growth arrest-specific gene expression. J Biol Chem 2003: 278: 43846-43854.
43. Dimri G P, Testori A, Acosta M, Campisi J. Replicative senescence, aging and growth- regulatory transcription factors. Biol Signals 1996: 5: 154-162.
44. Sheerin A, Thompson K S J, Goyns M H. Altered composition and DNA binding activity of the AP-1 transcription factor during the ageing of human fibroblasts. Mech Ageing Dev 2001: 122: 1813-1824.
45. Kang M K, Kameta A, Shin K H, Baluda M A, Kim H R, Park N H. Senescence-associated genes in normal human oral keratinocytes. Exp Cell Res 2003: 287: 272-281.
46. Riabowol K T. Transcription factor activity during cellular aging of human diploid fibroblasts. Biochem Cell Biol 1992: 70: 1064-1072.
47. Sikora E, Kaminska B, Radziszewska E, Kaczmarek L. Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo. FEBS Lett 1992: 312: 179-182.
48. Tolijima E, Inoue D, Yamamoto N et al. Decrease AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice. J Bone Miner Res 2003: 18: 1461-1470.
49. Gherzi R, Bellini C, Bonioli E. Altered response to stimuli of the AP-1/DNA binding activity in a syndrome of precocious ageing (geroderma osteodysplastica hereditaria). Mech Ageing Dev 1998: 100: 169-175.
50. Lucibello F C, Brusselbach S, Sewing A, Muller R. Suppression of the growth factor- mediated induction of c-fos and down-modulation of AP-1-binding activity are not required for cellular senescence. Oncogene 1993: 8: 1667-1672.
51. Grassilli E, Bellesia E, Salomoni P et al. c-fos/c-jun expression and AP-1 activation in skin fibroblasts from centenarians. Biochem Biophys Res Commun 1996: 226: 517-523.
52. Gorgas G, Butch E R, Guan K L, Miller R A. Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice. Mech Ageing Dev 1997: 94: 71-83.
53. Hutter D, Yo Y, Chen W et al. Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor. J Gerontol A Biol Sci Med Sci 2000: 55: B125-B134.
54. Li M, Torres C, Acuna-Castillo C et al. Defect in ERK2 and p54 (JNK) activation in aging mouse splenocytes. J Gerontol A Biol Sci Med Sci 2002: 57: B41-B47.
55. Reenstra W R, Yaar M, Gilchrest B A. Effect of donor age on epidermal growth factor processing in man. Exp Cell Res 1993: 209: 118-122.
56. Lorenzini A, Tresini M, Mawal-Dewan M et al. Role of the Raf/MEK/ERK and the P13K/Akt (PKB) pathways in fibroblast senescence. Exp Gerontol 2002: 37: 1149-1156.
57. Keogh B P, Tresini M, Cristofalo V J, Allen R G. Effects of cellular aging on the induction of c-fos by antioxidant treatments. Mech Ageing Dev 1996: 86: 151-160.
58. Gruda MC, Kovary K, Metz R, Bravo R. Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity. Oncogene 1994: 9: 2537-2547.