Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice

Journal of Bone and Mineral Research

Volumn 18, Issue 8, 2003, Pages 1461-1470

  Tohjima, Emiko ^a   Inoue, Daisuke ^a   Yamamoto, Nobuchika ^b   Kido, Shinsuke ^a   Ito, Yuji ^a   Kato, Shuji ^a   Takeuchi, Yasuhiro ^c   Fukumoto, Seiji ^c   Matsumoto, Toshio ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Activating protein 1; Interleukin 11; Promoter; Senescence accelerated mice; Senile osteoporosis

Indexed keywords

INTERLEUKIN 11; TRANSCRIPTION FACTOR AP 1; MESSENGER RNA; PROTEIN C JUN;

AGING; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; MOLECULAR CLONING; MOUSE; NONHUMAN; OSSIFICATION; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; STROMA CELL; TATA BOX; 5' UNTRANSLATED REGION; ANIMAL; BONE DEVELOPMENT; BONE MARROW CELL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SEQUENCE ALIGNMENT;

5' UNTRANSLATED REGIONS; AGING; ANIMALS; BASE SEQUENCE; BONE MARROW CELLS; CELL LINE; CLONING, MOLECULAR; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-11; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; OSTEOGENESIS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; SEQUENCE ALIGNMENT; STROMAL CELLS; TRANSCRIPTION FACTOR AP-1;

EID: 2142650270     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.8.1461     Document Type: Article

References (33)

1. Riggs BL, Khosla S, Melton LJ III 1998 A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13:763-773.
2. Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311.
3. Lindsay R, Hart DM, Forrest C, Baird C 1980 Prevention of spinal osteoporosis in oophorectomised women. Lancet 2:1151-1154.
4. Parfitt AM, Villanueva AR, Foldes J, Rao DS 1995 Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res 10:466-473.
5. Takeda T, Hosokawa M, Higuchi K 1997 Senescence-accelerated mouse (SAM): A novel murine model of senescence. Exp Gerontol 32:105-109.
6. Matsushita M, Tsuboyama T, Kasai R, Okumura H, Yamamuro T, Higuchi K, Higuchi K, Kohno A, Yonezu T, Utani A, Umezawa M, Takeda T 1986 Age-related changes in bone mass in the senescence-accelerated mouse (SAM) SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am J Pathol 125:276-283.
7. Jilka RL, Weinstein RS, Takahashi K, Parfitt AM, Manolagas SC 1996 Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest 97:1732-1740.
8. Nuttall ME, Gimble JM 2000 Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone 27:177-184.
9. Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC, Lipschitz DA 1997 Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 12:1772-1779.
10. Kodama Y, Takeuchi Y, Suzawa M, Fukumoto S, Murayama H, Yamato H, Fujita T, Kurokawa T, Matsumoto T 1998 Reduced expression of interleukin-11 in bone marrow stromal cells of senescence-accelerated mice (SAMP6): Relationship to osteopenia with enhanced adipogenesis. J Bone Miner Res 13:1370-1377.
11. Sambrook J, Russell D 2001 Hybridization of bacteriophage DNA on filters. In: Molecular Cloning: A Laboratory Manual, 3rd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, pp. 2.96-2.100.
12. Inoue D, Santiago P, Home WC, Baron R 1997 Identification of an osteoclast transcription factor that binds to the human T cell leukemia virus type I-long terminal repeat enhancer element. J Biol Chem 272:25386-25393.
13. Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF 1999 Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 13:607-619.
14. Tang W, Yang L, Yang YC, Leng SX, Elias JA 1998 Transforming growth factor-beta stimulates interleukin-11 transcription via complex activating protein-1-dependent pathways. J Biol Chem 273:5506-5513.
15. Du X, Williams DA 1997 Interleukin-11: Review of molecular, cell biology, and clinical use. Blood 89:3897-3908.
16. Heymann D, Rousselle AV 2000 gp130 Cytokine family and bone cells. Cytokine 12:1455-1468.
17. Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y 1991 Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Lett 283:199-202.
18. Ohsumi J, Miyadai K, Kawashima I, Ishikawa-Ohsumi H, Sakakibara S, Mita-Honjo K, Takiguchi Y 1991 Adipogenesis inhibitory factor. A novel inhibitory regulator of adipose conversion in bone marrow. FEBS Lett 288:13-16.
19. Keller DC, Du XX, Srour EF, Hoffman R, Williams DA 1993 Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures. Blood 82:1428-1435.
20. Suga K, Saitoh M, Fukushima S, Takahashi K, Nara H, Yasuda S, Miyata K 2001 Interleukin-11 induces osteoblast differentiation and acts synergistically with bone morphogenetic protein-2 in C3H10T1/2 cells. J Interferon Cytokine Res 21:695-707.
21. Verhaeghe J, Van Herck E, van Bree R, Bouillon R, Dequeker J, Keith JC Jr 1998 Recombinant human interleukin-11 does not modify biochemical parameters of bone remodeling and bone mineral density in adult ovariectomized rats. J Interferon Cytokine Res 18:49-53.
22. Girasole G, Passeri G, Jilka RL, Manolagas SC 1994 Interleukin-11: A new cytokine critical for osteoclast development. J Clin Invest 93:1516-1524.
23. Takeuchi Y, Watanabe S, Ishii G, Takeda S, Nakayama K, Fukumoto S, Kaneta Y, Inoue D, Matsumoto T, Harigaya K, Fujita T 2002 Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem 277:49011-49018.
24. Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado H, Kimoto M, Takeda N, Matsushita M, Okumura H, Serikawa T, Nakamura T, Johnson TE, Hosokawa M 1999 Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome 10:81-87.
25. Fang MA, Kujubu DA, Hahn TJ 1992 The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells. Endocrinology 131:2113-2119.
26. Lee K, Deeds JD, Chiba S, Un-No M, Bond AT, Segre GV 1994 Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: In situ localization of its receptor and c-fos messenger ribonucleic acids. Endocrinology 134:441-450.
27. Onyia JE, Bidwell J, Herring J, Hulman J, Hock JM 1995 In vivo, human parathyroid hormone fragment (hPTH 1-34) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats. Bone 17:479-484.
28. Lean JM, Mackay AG, Chow JW, Chambers TJ 1996 Osteocytic expression of mRNA for c-fos and IGF-I: An immediate early gene response to an osteogenic stimulus. Am J Physiol 270:E937-E945.
29. Mikuni-Takagaki Y 1999 Mechanical responses and signal transduction pathways in stretched osteocytes. J Bone Miner Metab 17:57-60.
30. Fitzgerald J, Hughes-Fulford M 1999 Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts. FASEB J 13:553-557.
31. Grigoriadis AE, Schellander K, Wang ZQ, Wagner EF 1993 Osteoblasts are target cells for transformation in c-fos transgenic mice. J Cell Biol 122:685-701.
32. Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R 2000 Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med 6:985-990.
33. Jochum W, David JP, Elliott C, Wutz A, Plenk H Jr, Matsuo K, Wagner EF 2000 Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6:980-984.