Defect in ERK2 and p54JNK activation in aging mouse splenocytes

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 57, Issue 2, 2002, Pages B41-B47

  Li, Min ^a   Torres, Claudio ^a   Acuña Castillo, Claudio ^b   Walter, Robin ^a,b   Gardner, Elizabeth M ^a   Murasko, Donna M ^a   Sierra, Felipe ^a,b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL AGING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPLEEN CELL;

AGING; ANIMALS; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES; SPLEEN;

ANIMALIA;

EID: 0036177237     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/57.2.B41     Document Type: Article

References (52)

1. Signal transduction by the TCR for antigen
2. Adapter proteins in lymphocyte antigen-receptor signalling
3. Ras regulation and function in lymphocytes
4. Contingent genetic regulatory events in T lymphocyte activation
5. Raf-I is required for T cell IL2 production
6. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy
7. JNK is involved in signal integration during costimulation of T lymphocytes
8. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
9. Regulation and function of the JNK subgroup of MAP kinases
10. Identification of an oncoprotein and UV responsive kinase that binds and potentiates the activity of the c-jun activation domain
11. 2-terminal kinase I and MKK3/p38 pathways regulated by MEK kinase 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
12. Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ, cellular, and activity changes
13. Age influence on the immune system
14. T-cell function in aging: Mechanism of decline
15. T cell immunosenescence in vitro and in vivo
16. The effect of age on the expression of interleukin-2
17. T cell signaling: Effect of age
18. Tcell and aging
19. Aging and immune function
20. Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: Differential effects of aging
21. lck in human T cells
22. ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T-cells from rats
23. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals
24. Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: Effect of age
25. mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex
26. Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice
27. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals
28. Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging
29. Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes
30. Age-sensitive-insensitive pathways leading to JNK activation in mouse CD4(+) T-cells
31. Activation of human T lymphocytes by phorbol-12, 13-dibutyrate and ionomycin
32. Impairment of signal transduction in T cells from old mice
33. Activation of MAP2-kinase in B lymphocytes by calcium ionophores
34. The aging immune system: Primer and prospectus
35. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells
36. Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice
37. Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli
38. Tyrosine-specific protein phosphorylation in response to anti-CD-3 antibody is diminished in old mice
39. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
40. Modulation of the ERK pathway of signal transduction by cysteine proteinase inhibitors
41. Decreases in growth hormone receptor signal transduction contribute to the decline in insulin like growth factor I gene expression with age
42. Age-related decline in mitogen activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes
43. Age-dependent decline in mitogenic stimulation of hepatocytes
44. Age-associated impairment in brain MAPK signal pathways and the effect of caloric restriction in Fischer 344 rats
45. Immunosenescence
46. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells
47. Blocked ras activation in anergic CD4+ T cells
48. Evidence for repression of IL-2 gene activation in anergic T cells
49. + T cell subsets in human peripheral blood
50. Phenotypic and functional properties of B lymphocytes from aged mice
51. Nathan Shock Memorial Lecture 1992 aging and immune function: Cellular and biochemical analyses
52. Protein kinase Ca-mediated chronic signal transduction for immunosenescence