Ultraviolet B-mediated phosphorylation of the small heat shock protein HSP27 in human keratinocytes

Journal of Investigative Dermatology

Volumn 115, Issue 3, 2000, Pages 427-434

  Wong, Jon W ^a,b   Shi, Biao ^b,c   Farboud, Behnom ^b   McClaren, Marla ^b   Shibamoto, Takayuki ^a   Cross, Carroll E ^b   Isseroff, R Rivkah ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c National Laboratory Center   (United States)

Author keywords

27kDa heat shock protein translocation; Actin filaments; Oxidative stress; P38 MAP kinase; Signal transduction

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE;

ACTIN FILAMENT; ARTICLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; KERATINOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION;

EID: 0033828469     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00077.x     Document Type: Article

References (53)

1. Interleukin-3 and granulocyte-macrophage colony-stimulating factor induce activation of the MAPKAP kinase 2 resulting in in vitro serine phosphorylation of the small heat shock protein (Hsp 27)
2. Differential stimulation of ERK and JNK activities by ultraviolet B irradiation and epidermal growth factor in human keratinocytes
3. Stress (heat shock) proteins. Molecular chaperones in cardiovascular biology and disease
4. Isoelectric focusing and two dimensional gel electrophoresis
5. Induction of HSP 32 gene in hypoxic cardiomyocytes is attenuated by treatment with N-acyl-L-cysteine
6. The molecular chaperone α-crystallin inhibits UV-induced protein aggregation
7. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino) -6,7-dimethoxyquinazoline (PD 153035) a potent inhibitor of the epidermal growth factor receptor
8. Biological and clinical implications of heat shock protein 27000 (Hsp27): A review
9. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
10. Free radicals in cutaneous biology
11. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase
12. MAPKAP kinase 2 is activated by heat shock and TNF-α: In vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade
13. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
14. Suppression of UVB-induced c-fos and c-jun expression in human keratinocytes by N-acetylcysteine
15. Mechanisms of ultraviolet light-induced pigmentation
16. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
17. Activation of the transcription factor MER2C by the MAP kinase p38 in inflammation
18. UV activates growth factor receptors via reactive oxygen intermediates
19. Characterization of 45-kDa/54-kDa HSP27 kinase a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27
20. Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes
21. Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermotolerance
22. An essential role for free radicals and derived species in signal transduction
23. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27
24. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock HSP27 stabilization of the microfilament organization
25. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27
26. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
27. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway
28. Differential effects of heat shock and UVB light upon stress protein expression in epidermal keratinocytes
29. Heat shock proteins and molecular chaperones: Implications for adaptive responses in the skin
30. Dynamic changes in intracellular localization and isoforms of the 27-kD stress protein in human keratinocytes
31. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation
32. A 25-kD inhibitor of actin polymerization is a low molecular mass heat-shock protein
33. The p38 MAP kinase pathway and its biological function
34. UVB irradiation induces changes in cellular localization and phosphorylation of mouse HSP27
35. 2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes
36. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes
37. Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery
38. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
39. Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes
40. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
41. Identification of a protein transiently phosphorylated by activators of endothelial cell function as the heat shock protein HSP27. A possible role for protein kinase C
42. Thapsigargin induces phosphorylation of the 27-kDa heat shock protein in human keratinocytes
43. Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells
44. UVB light induces nuclear factor κB (NFκB) activity independently from chromosomal DNA damage in cell-free cytosolic extracts
45. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
46. Stress proteins in the cellular response to ultraviolet radiation
47. Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line
48. Regulation of transcription by MAP kinase cascades
49. Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds
50. α-Crystallin stabilizes actin filaments and prevents cytochalasin-induced depolymerization in a phosphorylation-dependent manner
51. Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor
52. An immunofluorescence study of the effects of ultraviolet radiation on the organization of microfilaments, keratin intermediate filaments and microtubules in human keratinocytes