Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability

Thrombosis and Haemostasis

Volumn 84, Issue 5, 2000, Pages 865-870

  Yu, I S ^a   Chen, H J ^a   Lee, Y S E ^a   Huang, P H ^a   Lin, S R ^a   Tsai, T W ^a   Lin, S W ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Gene targeting and liver regeneration; Hepsin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE BONE ISOENZYME; ASPARTATE AMINOTRANSFERASE; HEPSIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL GROWTH; EMBRYO DEVELOPMENT; ENZYME MECHANISM; FEMALE; GENE TARGETING; HOMOZYGOSITY; IN VIVO STUDY; LIVER CELL; LIVER INJURY; LIVER REGENERATION; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033724609     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614129     Document Type: Article

References (40)

1. Hepsin
2. A Novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells
3. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos
4. Hepsin, a cell membrane-associated protease
5. Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer
6. Expression of the factor VII activating protease, Hepsin, in situ in renal cell carcinoma
7. The tissue factor pathway: How it has become a 'Prima Ballerina'
8. Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth
9. Complete nucleotide sequence, origin of isoform and functional characterization of the mouse hepsin gene
10. Prediction of the secondary structure of proteins from their amino acid sequence
11. Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation
12. Enhancement of the expression of urokinase-type plasminogen activator from PC-3 human prostate cancer cells by thrombin
13. Thrombin increases the metastatic potential of tumor cells
14. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo
15. Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo
16. Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix
17. A study of the mechanism by which anticoagulant with warfarin inhibits blood-bone metastasis
18. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells
19. Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease
20. Neonatal lethality and lymphopenia in mice with homozygous disruption of the c-abl protooncogen
21. Mice lacking vimentin develop and reproduce without an obvious phenotype
22. Gene targeting in embryonic stem cells
23. Engineered recombinant factor VII Q217 variants with altered inhibitor specificities
24. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal
25. Measurement of basal levels factor VIIa in hemophilia A and B patients
26. Liver regeneration
27. Cancer metastasis: Tumor cell and host organ properties important in metastasis to specific secondary sites
28. Tumor heterogenity and the biology of cancer invasion and metastasis
29. Human breast carcinoma: Fibrin deposits and desmoplasia inflammatory cell type and distribution, Microvasculature and infaction
30. Occurrence of fibrin and tissue factor antigen in human small cell carcinoma of the lung
31. Tissue factor as a tumor procoagulant
32. Cancer cell procoagulants and their role in malignant disease
33. Fibrin and cancer
34. Pathways of coagulation/fibrinolysis activation in malignancy
35. Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate: Final report of VA cooperative study no. 75
36. Involvement of plasmogen activator production with tumor metastasis in a rat model
37. A correlation between urokinase-type plasminogen activator production and the metastatic ability of human rectal cancer cells