CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 2, 2005, Pages 397-416

  Imamura, Shinichi ^a   Nishikawa, Youichi ^a   Ichikawa, Takashi ^a   Hattori, Taeko ^a   Matsushita, Yoshihiro ^a   Hashiguchi, Shohei ^a   Kanzaki, Naoyuki ^a   Iizawa, Yuji ^a   Baba, Masanori ^b   Sugihara, Yoshihiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Grad Sch Med Dent Sci K   (Japan)

Author keywords

CCR5 antagonist; Chemokine; HIV 1; Piperidine 4 carboxamide

Indexed keywords

1 ACETYL N (3 CHLORO 4 ISOPROPYLPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHOXYPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLOROPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3,4 DICHLOROPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N (3 CHLORO 4 METHYLPHENYL)PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N (3,4 DICHLOROPHENYL) PIPERIDINE 4 CARBOXYLATE; 1 ACETYL N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N PHENYLPIPERIDINE 3 CARBOXAMIDE; 1 ACETYL N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N PHENYLPIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N (4 METHYLPHENYL)PIPERIDINE 4 CARBOXAMIDE; 1 BENZOYL N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N PHENYLPIPERIDINE 4 CARBOXAMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZYL 3 [[[3 (4 BENZYLPIPERIDIN 1 YL)PROPYL](PHENYL)AMINO]CARBONYL] PIPERIDINE 1 CARBOXYLATE; BENZYL 4 [[[3 (4 BENZYLPIPERIDIN 1 YL)PROPYL](PHENYL)AMINO]CARBONYL] PIPERIDINE 1 CARBOXYLATE FUMARATE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] 1 (METHYLSULFONYL)PIPERIDINE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) 1 (METHYLSULFONYL) N [3 [4 (4 MORPHOLIN 4 YLBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) 1 (METHYLSULFONYL) N [3 [4 (4 NITROBENZYL)PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) 1 (METHYLSULFONYL) N [3 [4 [4 (METHYLSULFONYL) BENZYL]PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) 1 (METHYLSULFONYL) N [3 [4 [4 (TRIFLUOROMETHYL) BENZYL]PIPERIDIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] 1 (METHYLSULFONYL)PIPERIDINE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) N [3 [4 (4 METHOXYBENZYL)PIPERIDIN 1 YL]PROPYL] 1 (METHYLSULFONYL)PIPERIDINE 4 CARBOXAMIDE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] 1 (METHYLSULFONYL) N PHENYLPIPERIDINE 3 CARBOXAMIDE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] 1 (METHYLSULFONYL) N PHENYLPIPERIDINE 4 CARBOXAMIDE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] 1 ISOBUTYRYL N PHENYLPIPERIDINE 4 CARBOXAMIDE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N PHENYLPIPERIDINE 3 CARBOXAMIDE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N PHENYLPIPERIDINE 4 CARBOXAMIDE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DOGS; HIV-1; HUMANS; MALE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; RATS; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 20844433373     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.013     Document Type: Article

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