Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 40, 2004, Pages 14326-14332

  Blanchard, Barbara J ^a   Chen, Albert ^a   Rozeboom, Leslie M ^a   Stafford, Kate A ^a   Weigele, Peter ^a   Ingram, Vernon M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aggregation; Amyloid peptide; Ca ions; Toxicity

Indexed keywords

4,5 DIANILINOPHTHALIMIDE; AMPA RECEPTOR; AMYLOID BETA PROTEIN[1-42]; CALCIUM; LEAD; PHTHALIMIDE DERIVATIVE; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BETA SHEET; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; FIBER; FLUORESCENCE; INCUBATION TIME; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CALCIUM SIGNALING; DRUG EVALUATION, PRECLINICAL; HUMANS; MICROSCOPY, ELECTRON; NEUROFIBRILLARY TANGLES; NEURONS; NEUROTOXINS; PEPTIDE FRAGMENTS; PHTHALIMIDES; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, AMPA;

ANIMALIA;

EID: 5144220474     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0405941101     Document Type: Article

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