Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex

Journal of Biological Chemistry

Volumn 280, Issue 23, 2005, Pages 22318-22325

  Zang, Yang ^a   Wang, Wen Hu ^b   Wu, Shaw Wen ^b   Ealick, Steven E ^a   Wang, Ching C ^b  

^a Cornell University ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; COMPLEXATION; ENZYME INHIBITION; ENZYME KINETICS; MOLECULAR STRUCTURE; SUBSTRATES;

POTOZOAN PARASITE; PURINE NUCLEOSIDE PHOSPHORYLASE (PNP); SUBVERSIVE SUBSTRATE; X-RAY CRYSTALLOGRPAHY;

ENZYMES;

2 DEOXYINOSINE; 2 FLUOROADENINE; 2' DEOXY 2 FLUOROADENOSINE; ADENINE DERIVATIVE; ADENOSINE; BACTERIAL ENZYME; FORMYCIN; INOSINE; INOSINE DERIVATIVE; MONOMER; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; TRICHOMONAS VAGINALIS; X RAY CRYSTALLOGRAPHY;

ADENINE; ADENOSINE; ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRONS; FORMYCINS; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; INOSINE; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THREONINE; TIME FACTORS; TRICHOMONAS VAGINALIS; X-RAYS;

ESCHERICHIA COLI; PROTOZOA; TRICHOMONAS VAGINALIS;

EID: 20444454249     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501843200     Document Type: Article

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