Rational design of novel antimicrobials: Blocking purine salvage in a parasitic protozoan

Biochemistry

Volumn 37, Issue 16, 1998, Pages 5344-5348

  Somoza, John R ^b   Skillman Jr , A Geoffrey ^a   Munagala, Narsimha R ^a   Oshiro, C M ^a   Knegtel, Ronald M A ^c   Mpoke, Solomon ^a   Fletterick, Robert J ^b   Kuntz, Irwin D ^a   Wang, Ching C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N (3,4 DICHLOROPHENYL)CARBAMOYL]PTHALIC ANHYDRIDE; ANTIPROTOZOAL AGENT; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITION; HOST PARASITE INTERACTION; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PURINE METABOLISM; STRUCTURE ANALYSIS; TRICHOMONAS FOETUS;

ANIMALS; ANTITRICHOMONAL AGENTS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MODELS, MOLECULAR; PURINE NUCLEOSIDES; TRITRICHOMONAS FOETUS;

EID: 0032554638     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi973095z     Document Type: Article

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