Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis

Journal of the Neurological Sciences

Volumn 233, Issue 1-2, 2005, Pages 203-208

  De Stefano, Nicola ^a   Bartolozzi, Maria L ^b   Guidi, Leonello ^b   Stromillo, Maria L ^a   Federico, Antonio ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b Hospital of Empoli   (Italy)

Author keywords

Brain damage; Magnetic resonance spectroscopy; Multiple sclerosis

Indexed keywords

N ACETYLASPARTIC ACID;

BRAIN INJURY; BRAIN TISSUE; CONFERENCE PAPER; DISABILITY; HUMAN; MEASUREMENT; MULTIPLE SCLEROSIS; NERVE DEGENERATION; PATHOGENESIS; PATIENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ASPARTIC ACID; AXONS; BRAIN DISEASES; CREATINE; DISABILITY EVALUATION; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MULTIPLE SCLEROSIS; SEVERITY OF ILLNESS INDEX;

EID: 20444395821     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2005.03.018     Document Type: Conference Paper

References (73)

1. B.D. Trapp, J. Peterson, R.M. Ransohoff, R. Rudick, S. Mork, and L. Bo Axonal transection in the lesions of multiple sclerosis N Engl J Med 338 1998 278 285
2. P.M. Matthews, N. De Stefano, S. Narayanan, G.S. Francis, J.S. Wolinsky, and J.P. Antel Putting magnetic resonance spectroscopy studies in context: axonal damage and disability in multiple sclerosis Semin Neurol 18 1998 327 336
3. J.S. Wolinsky, and P.A. Narayana Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain Curr Opin Neurol 15 2002 247 251
4. B. Ferguson, M.K. Matyszak, M.M. Esiri, and V.H. Perry Axonal damage in acute multiple sclerosis lesions Brain 120 1997 393 399
5. J.W. Peterson, L. Bo, S. Mork, A. Chang, and B.D. Trapp Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions Ann Neurol 50 2001 389 400
6. B.D. Trapp, R.M. Ransohoff, E. Fisher, and R.A. Rudick Neurodegeneration in multiple sclerosis: relationship to neurological disability Neuroscientist 5 1999 48 57
7. P.M. Matthews, and D.L. Arnold Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution Curr Opin Neurol 14 2001 279 287
8. M. Filippi, and R.I. Grossman MRI techniques to monitor MS evolution: the present and the future Neurology 58 2002 1147 1153
9. R.E. Gordon, P.E. Hanley, D. Shaw, D.G. Gadian, G.K. Radda, and P. Styles Localization of metabolites in animals using 31P topical magnetic resonance Nature 287 1980 736 738
10. O. Gonen, A.K. Viswanathan, I. Catalaa, J. Babb, J. Udupa, and R.I. Grossman Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy Magn Reson Med 40 1998 684 689
11. D.L. Arnold, and P.M. Matthews Pratical aspects of clinical applications of MRS in the brain I.R. Young H.C. Charles MR spectroscopy: clinical applications and techniques 1996 Martin Dunitz London 139 159
12. C.A. Husted, D.S. Goodin, J.W. Hugg, A.A. Maudsley, J.S. Tsuruda, and S.H. de Bie Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging Ann Neurol 36 1994 157 165
13. H.P. Hetherington, J.W. Pan, G.F. Mason, D. Adams, M.J. Vaughn, and D.B. Twieg Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation Magn Reson Med 36 1996 21 29
14. C.A. Davie, G.J. Barker, A.J. Thompson, P.S. Tofts, W.I. McDonald, and D.H. Miller 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis J Neurol Neurosurg Psychiatry 63 1997 736 742
15. C.A. Davie, N.C. Silver, G.J. Barker, P.S. Tofts, A.J. Thompson, and W.I. McDonald Does the extent of axonal loss and demyelination from chronic lesions in multiple sclerosis correlate with the clinical subgroup? J Neurol Neurosurg Psychiatry 67 1999 710 715
16. P. Sarchielli, O. Presciutti, G.P. Pelliccioli, R. Tarducci, G. Gobbi, and P. Chiarini Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients Brain 122 1999 513 521
17. M.A. van Walderveen, F. Barkhof, P.J. Pouwels, S.R. van, C.H. Polman, and J.A. Castelijns Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy Ann Neurol 46 1999 79 87
18. P.A. Narayana, T.J. Doyle, D. Lai, and J.S. Wolinsky Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis Ann Neurol 43 1998 56 71
19. S.E. Davies, J. Newcombe, S.R. Williams, W.I. McDonald, and J.B. Clark High resolution proton NMR spectroscopy of multiple sclerosis lesions J. Neurochem. 64 1995 742 748
20. C.A. Davie, C.P. Hawkins, G.J. Barker, A. Brennan, P.S. Tofts, and D.H. Miller Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions Brain 117 1994 49 58
21. N. De Stefano, P.M. Matthews, J.P. Antel, M. Preul, G. Francis, and D.L. Arnold Chemical pathology of acute demyelinating lesions and its correlation with disability Ann Neurol 38 1995 901 909
22. N. De Stefano, P.M. Matthews, and D.L. Arnold Reversible decreases in N-acetylaspartate after acute brain injury Magn Reson Med 34 1995 721 727
23. D.L. Arnold, P.M. Matthews, G. Francis, and J. Antel Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease Magn Reson Med 14 1990 154 159
24. J.S. Wolinsky, P.A. Narayana, and M.J. Fenstermacher Proton magnetic resonance spectroscopy in multiple sclerosis Neurology 40 1990 1764 1769
25. S. Narayanan, L. Fu, E. Pioro, N. De Stefano, D.L. Collins, and G.S. Francis Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions Ann Neurol 41 1997 385 391
26. L. Fu, P.M. Matthews, N. De Stefano, K.J. Worsley, S. Narayanan, and G.S. Francis Imaging axonal damage of normal-appearing white matter in multiple sclerosis Brain 121 1998 103 113
27. N. De Stefano, S. Narayanan, P.M. Matthews, G.S. Francis, J.P. Antel, and D.L. Arnold In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis Brain 122 1999 1933 1939
28. N. De Stefano, S. Narayanan, S.J. Francis, S. Smith, M. Mortilla, and M.C. Tartaglia Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability Arch Neurol 59 2002 1565 1571
29. K.T. Fernando, M.A. McLean, D.T. Chard, D.G. MacManus, C.M. Dalton, and K.A. Miszkiel Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis Brain 127 2004 1361 1369
30. P. Kapeller, M.A. McLean, C.M. Griffin, D. Chard, G.J. Parker, and G.J. Barker Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study J Neurol 248 2001 131 138
31. D.T. Chard, C.M. Griffin, M.A. McLean, P. Kapeller, R. Kapoor, and A.J. Thompson Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis Brain 125 2002 2342 2352
32. M. Filippi, M.A. Rocca, G. Martino, M.A. Horsfield, and G. Comi Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis Ann Neurol 43 1998 809 814
33. D.E. Goodkin, W.D. Rooney, R. Sloan, P. Bacchetti, L. Gee, and M. Vermathen A serial study of new MS lesions and the white matter from which they arise Neurology 51 1998 1689 1697
34. G.B. Pike, N. De Stefano, S. Narayanan, K.J. Worsley, D. Pelletier, and G.S. Francis Multiple sclerosis: magnetization transfer MR imaging of white matter before lesion appearance on T2-weighted images Radiology 215 2000 824 830
35. M.C. Tartaglia, S. Narayanan, N. De Stefano, R. Arnaoutelis, S.B. Antel, and S.J. Francis Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis J Neurol 249 2002 1382 1390
36. R. Sharma, P.A. Narayana, and J.S. Wolinsky Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging Mult Scler 7 2001 221 226
37. A. Cifelli, M. Arridge, P. Jezzard, M.M. Esiri, J. Palace, and P.M. Matthews Thalamic neurodegeneration in multiple sclerosis Ann Neurol 52 2002 650 653
38. P. Sarchielli, O. Presciutti, R. Tarducci, G. Gobbi, A. Alberti, and G.P. Pelliccioli Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis J Neurol 249 2002 902 910
39. M. Wylezinska, A. Cifelli, P. Jezzard, J. Palace, M. Alecci, and P.M. Matthews Thalamic neurodegeneration in relapsing-remitting multiple sclerosis Neurology 60 2003 1949 1954
40. E. Adalsteinsson, A. Langer-Gould, R.J. Homer, A. Rao, E.V. Sullivan, and C.A. Lima Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis AJNR Am J Neuroradiol 24 2003 1941 1945
41. D. Kidd, F. Barkhof, R. McConnell, P.R. Algra, I.V. Allen, and T. Revesz Cortical lesions in multiple sclerosis Brain 122 1999 17 26
42. M. Cercignani, M. Bozzali, G. Iannucci, G. Comi, and M. Filippi Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis J Neurol Neurosurg Psychiatry 70 2001 311 317
43. M. Rovaris, M. Bozzali, G. Iannucci, A. Ghezzi, D. Caputo, and E. Montanari Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study Arch Neurol 59 2002 1406 1412
44. D.T. Chard, C.M. Griffin, G.J. Parker, R. Kapoor, A.J. Thompson, and D.H. Miller Brain atrophy in clinically early relapsing-remitting multiple sclerosis Brain 125 2002 327 337
45. N. De Stefano, P.M. Matthews, M. Filippi, F. Agosta, M. De Luca, and M.L. Bartolozzi Evidence of early cortical atrophy in MS: relevance to white matter changes and disability Neurology 60 2003 1157 1162
46. M.L. Simmons, C.G. Frondoza, and J.T. Coyle Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies Neuroscience 45 1991 37 45
47. J.R. Moffett, M.A.A. Namboodiri, C.B. Cangro, and J.H. Neale Immunohistochemical localization of N-acetylaspartate in rat brain NeuroReport 2 1991 131 134
48. J. Urenjak, S.R. Williams, D.G. Gadian, and M. Noble Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro J Neurochem 59 1992 55 61
49. K.K. Bhakoo, and D. Pearce In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo [In Process Citation] J Neurochem 74 2000 254 262
50. J.T. Coyle, M.B. Robinson, R.D. Blakely, and G.-L. Forloni The neurobiology of N-acetyl-aspartyl-glutamate E.A. Barnard E. Costa Allosteric modulation of amino acid receptors: therapeutic implications 1989 Raven Press New York 319 333
51. C. Bjartmar, J. Battistuta, N. Terada, E. Dupree, and B.D. Trapp N-Acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve Ann Neurol 51 2002 51 58
52. T.N. Sager, H. Laursen, A. Fink-Jensen, S. Topp, A. Stensgaard, and M. Hedehus N-Acetylaspartate distribution in rat brain striatum during acute brain ischemia J Cereb Blood Flow Metab 19 1999 164 172
53. P.M. Matthews, L. Cianfaglia, J. McLaurin, N. Cashman, A. Sherwin, and D.L. Arnold Demonstration of reversible decreases in N-acetylaspartate (NAA) in a neuronal cell line: NAA decreases as a marker of sublethal neuronal dysfunction Book Abstr-Soc Magn Reson Med 1 1995 147
54. N. De Stefano, S. Narayanan, G.S. Francis, R. Arnaoutelis, M.C. Tartaglia, and J.P. Antel Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability Arch Neurol 58 2001 65 70
55. I. Mews, M. Bergmann, S. Bunkowski, F. Gullotta, and W. Bruck Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions Mult Scler 4 1998 55 62
56. N. Evangelou, D. Konz, M.M. Esiri, S. Smith, J. Palace, and P.M. Matthews Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis Brain 123 Pt 9 2000 1845 1849
57. R. Hohlfeld Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives Brain 120 Pt 5 1997 865 916
58. T. Moreau, A. Coles, M. Wing, J. Isaacs, G. Hale, and H. Waldmann Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis Brain 119 1996 225 237
59. + current Brain 119 1996 457 463
60. R.A. Moumdjian, J.P. Antel, and V.W. Yong Origin of contralateral reactive gliosis in surgically injured rat cerebral cortex Brain Res 547 1991 223 228
61. P. Rieckmann, and K.J. Smith Multiple sclerosis: more than inflammation and demyelination Trends Neurosci 24 2001 435 437
62. A. Bitsch, J. Schuchardt, S. Bunkowski, T. Kuhlmann, and W. Bruck Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation Brain 123 Pt 6 2000 1174 1183
63. J.Y. Garbern, D.A. Yool, G.J. Moore, I.B. Wilds, M.W. Faulk, and M. Klugmann Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation Brain 125 2002 551 561
64. N. De Stefano, P.M. Matthews, S. Narayanan, G.S. Francis, J.P. Antel, and D.L. Arnold Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient Neurology 49 1997 1138 1141
65. N. De Stefano, P.M. Matthews, L. Fu, S. Narayanan, J. Stanley, and G.S. Francis Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study Brain 121 1998 1469 1477
66. A. Cifelli, and P.M. Matthews Cerebral plasticity in multiple sclerosis: insights from fMRI Mult Scler 8 2002 193 199
67. B.D. Trapp, L. Bo, S. Mork, and A. Chang Pathogenesis of tissue injury in MS lesions J. Neuroimmunol. 98 1999 49 56
68. B.D. Trapp, R. Ransohoff, and R. Rudick Axonal pathology in multiple sclerosis: relationship to neurologic disability Curr Opin Neurol 12 1999 295 302
69. S.G. Waxman Molecular remodeling of neurons in multiple sclerosis: what we know, and what we must ask about brain plasticity in demyelinating diseases Adv Neurol 73 1997 109 120
70. C. Moll, C. Mourre, M. Lazdunski, and J. Ulrich Increase of sodium channels in demyelinated lesions of multiple sclerosis Brain Res 556 1991 311 316
71. J.A. Black, P. Felts, K.J. Smith, J.D. Kocsis, and S.G. Waxman Distribution of sodium channels in chronically demyelinated spinal cord axons: immuno-ultrastructural localization and electrophysiological observations Brain Res 544 1991 59 70
72. M. Lee, H. Reddy, H. Johansen-Berg, S. Pendlebury, M. Jenkinson, and S. Smith The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis Ann Neurol 47 2000 606 613
73. H. Reddy, S. Narayanan, R. Arnoutelis, M. Jenkinson, J. Antel, and P.M. Matthews Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis Brain 123 Pt 11 2000 2314 2320