Brain atrophy in clinically early relapsing-remitting multiple sclerosis

Brain

Volumn 125, Issue 2, 2002, Pages 327-337

  Chard, D T ^a   Griffin, C M ^a   Parker, G J M ^a   Kapoor, R ^a   Thompson, A J ^a   Miller, D H ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Atrophy; Brain; MRI; Multiple sclerosis; Normal controls

Indexed keywords

GADOLINIUM;

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; DISABILITY; DISEASE COURSE; FEMALE; GRAY MATTER; HUMAN; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECURRENT DISEASE; REMISSION; THREE DIMENSIONAL IMAGING; WHITE MATTER;

EID: 0036161001     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awf025     Document Type: Article

References (56)

1. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis
2. Multimodal image coregistration and partitioning - A unified framework
3. Voxel-based morphometry - The methods
4. Quantitative volumetric analysis of brain MR: Normative database spanning 5 decades of life
5. Extensive cortical demyelination in multiple sclerosis brains
6. Detection of ventricular enlargement in patients at the earliest clinical stage of MS
7. The distribution of plaques in the cerebrum in multiple sclerosis
8. Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
9. Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
10. Age and gender effects on brain grey and white matter volumes in normal controls: The reproducibility and sensitivity of an SPM based segmentation methodology
11. Sex differences in brain aging: A quantitative magnetic resonance imaging study
12. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
13. Relation of cerebral atrophy in multiple sclerosis to severity of disease and axonal injury
14. Axonal damage in acute multiple sclerosis lesions
15. Increased spatial resolution using a three-dimensional T1-weighted gradient-echo MR sequence results in greater hypo-intense lesion volumes in multiple sclerosis
16. Progressive cerebral atrophy in MS: A serial study using registered, volumetric MRI
17. Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: Longitudinal quantitative analysis
18. White matter changes with normal aging
19. Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: Implications for clinical trials and natural history
20. Magnetic resonance imaging evaluation of the effects of ageing on grey-white ratio in the human brain
21. Intracranial volume and Alzheimer disease: Evidence against the cerebral reserve hypothesis
22. Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: A quantitative MR spectroscopic imaging study
23. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis
24. Cortical lesions in multiple sclerosis
25. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
26. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
27. Decreased gray matter in normal aging: An in vivo magnetic resonance study
28. Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis
29. Progressive cerebral atrophy in multiple sclerosis. A serial MRI study
30. Defining the clinical course of multiple sclerosis: Results of an international survey
31. A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis
32. Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: Absolute metabolic values over 2 years during a clinical pharmacological study
33. Variation with age in the volumes of grey and white matter in the cerebral hemispheres of man: Measurements with an image analyser
34. The effect of section thickness on MR lesion detection and quantification in multiple sclerosis
35. The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
36. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
37. Neocortical neuron number in humans: Effect of sex and age
38. Brain atrophy in relapsing-remitting multiple sclerosis: Relationship with 'black holes', disease duration and clinical disability
39. Age and sex effects on brain morphology
40. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood
41. Dispimage: A display and analysis tool for medical images
42. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
43. The fine structure of chronically active multiple sclerosis plaques
44. Reproducibility of brain MRI lesion volume measurements in multiple sclerosis using a local thresholding technique: Effects of formal operator training
45. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
46. The effect of gadolinium-enhancing lesions on whole brain atrophy in relapsing-remitting MS
47. Volume T1-weighted gradient echo MRI in multiple sclerosis patients
48. A longitudinal study of brain atrophy in relapsing multiple sclerosis
49. A Wallerian degeneration pattern in patients at risk for MS
50. One year follow up study of primary and transitional progressive multiple sclerosis
51. Major differences in the dynamics of primary and secondary progressive multiple sclerosis
52. Some spaces and barriers in postmortem multiple sclerosis
53. Axonal transection in the lesions of multiple sclerosis
54. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis
55. Gender effects on age-related changes in brain structure
56. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons