Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: Effects of fused heterocycles on antiviral activity and pharmacokinetic properties

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 8, 2005, Pages 2129-2134

  Kim, Dooseop ^a   Wang, Liping ^a   Hale, Jeffrey J ^a   Lynch, Christopher L ^a,b   Budhu, Richard J ^a   MacCoss, Malcolm ^a   Mills, Sander G ^a   Malkowitz, Lorraine ^a   Gould, Sandra L ^a   Demartino, Julie A ^a   Springer, Martin S ^a   Hazuda, Daria ^a   Miller, Michael ^a   Kessler, Joseph ^a   Hrin, Renee C ^a   Carver, Gwen ^a   Carella, Anthony ^a   Henry, Karen ^a   Lineberger, Janet ^a   Schleif, William A ^a   Emini, Emilio A ^a,c   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b ABBOTT LABORATORIES   (United States)

^c INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

Author keywords

Antiviral; CCR5; Fused heterocycles; HIV 1

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; HETEROCYCLIC COMPOUND; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; RAT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 20144388228     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.030     Document Type: Article

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