1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: Modifications of the arylpropylpiperidine side chains

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 119-123

  Lynch, Christopher L ^a   Willoughby, Christopher A ^a   Hale, Jeffrey J ^a   Holson, Edward J ^a   Budhu, Richard J ^a   Gentry, Amy L ^a   Rosauer, Keith G ^a   Caldwell, Charles G ^a   Chen, Ping ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Berk, Scott ^a   Chen, Liya ^a   Chapman, Kevin T ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Siciliano, Salvatore J ^a   Cascieri, Margaret A ^a   Carella, Anthony ^a   Carver, Gwen ^a   Holmes, Karen ^a   Schleif, William A ^a   Danzeisen, Renee ^a   Hazuda, Daria ^a   Kessler, Joseph ^a   Lineberger, Janet ^a   Miller, Michael ^a   Emini, Emilio A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; AROMATIC COMPOUND; CARBENE; CHEMOKINE RECEPTOR CCR5; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; SULFONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PIPERIDINE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; ANIMAL; CELL CULTURE; CHEMISTRY; DOG; DRUG ANTAGONISM; HALF LIFE TIME; HUMAN; MACACA; METABOLIC CLEARANCE RATE; MONONUCLEAR CELL; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-HIV AGENTS; DOGS; HALF-LIFE; HUMANS; LEUKOCYTES, MONONUCLEAR; MACACA MULATTA; METABOLIC CLEARANCE RATE; PIPERIDINES; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 18744416543     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00829-6     Document Type: Article

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