1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: Lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 20, 2001, Pages 2741-2745

  Hale, Jeffrey J ^a   Budhu, Richard J ^a   Holson, Edward B ^a   Finke, Paul E ^a   Oates, Bryan ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Springer, Martin S ^a   Siciliano, Salvatore ^a   Malkowitz, Lorraine ^a   Schleif, William A ^a   Hazuda, Daria ^a   Miller, Michael ^a   Kessler, Joseph ^a   Danzeisen, Renee ^a   Holmes, Karen ^a   Lineberger, Janet ^a   Carella, Anthony ^a   Carver, Gwen ^a   Emini, Emilio ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5; DRUG ANALOG; PYRROLIDINE CHEMOKINE RECEPTOR CCR5 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL AVAILABILITY; CHO CELLS; CRICETINAE; HELA CELLS; HIV; HUMANS; MICROBIAL SENSITIVITY TESTS; PYRROLIDINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035935205     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00545-5     Document Type: Article

References (15)