1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 427-431

  Willoughby, Christopher A ^a   Rosauer, Keith G ^a   Hale, Jeffery J ^a   Budhu, Richard J ^a   Mills, Sander G ^a   Chapman, Kevin T ^a   MacCoss, Malcolm ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Siciliano, Salvatore J ^a   Cascieri, Margaret A ^a   Carella, Anthony ^a   Carver, Gwen ^a   Holmes, Karen ^a   Schleif, William A ^a   Danzeisen, Renee ^a   Hazuda, Daria ^a   Kessler, Joseph ^a   Lineberger, Janet ^a   Miller, Michael ^a   Emini, Emilio A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; PYRROLIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG BINDING;

ANIMALS; ANTI-HIV AGENTS; CHO CELLS; CRICETINAE; HALF-LIFE; HELA CELLS; HUMANS; HYDROGEN BONDING; MACROPHAGE INFLAMMATORY PROTEIN-1; PIPERIDINES; PYRROLIDINES; RATS; RECEPTORS, CCR5;

EID: 0037330767     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00988-5     Document Type: Article

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