메뉴 건너뛰기




Volumn 33, Issue 9, 2005, Pages 2852-2858

HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN; DNA; HETEROCHROMATIN PROTEIN 1; HISTONE H3; REGULATOR PROTEIN; SERINE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DROSOPHILA PROTEIN; HETEROCHROMATIN PROTEIN 1, DROSOPHILA; HISTONE; NONHISTONE PROTEIN;

EID: 20144372036     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki584     Document Type: Article
Times cited : (75)

References (53)
  • 1
    • 0000251397 scopus 로고
    • Das heterochromatin der moose
    • Heitz, E. (1928) Das heterochromatin der moose. J. Jahrb. Wiss. Botanik. 69, 762-818.
    • (1928) J. Jahrb. Wiss. Botanik. , vol.69 , pp. 762-818
    • Heitz, E.1
  • 2
    • 0036532235 scopus 로고    scopus 로고
    • Heterochromatin: New possibilities for the inheritance of structure
    • Grewal, S.I. and Elgin, S.C. (2002) Heterochromatin: New possibilities for the inheritance of structure. Curr. Opin. Genet. Dev., 12, 178-187.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 178-187
    • Grewal, S.I.1    Elgin, S.C.2
  • 3
    • 0022818549 scopus 로고
    • Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene
    • James, T.C. and Elgin, S.C. (1986) Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol. Cell. Biol., 6, 3862-3872.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3862-3872
    • James, T.C.1    Elgin, S.C.2
  • 4
    • 0036966358 scopus 로고    scopus 로고
    • HP1: Facts, open questions, and speculation
    • Singh, P.B. and Georgatos, S.D. (2002) HP1: Facts, open questions, and speculation. J. Struct. Biol., 140, 10-16.
    • (2002) J. Struct. Biol. , vol.140 , pp. 10-16
    • Singh, P.B.1    Georgatos, S.D.2
  • 5
    • 0024445456 scopus 로고
    • Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila
    • James, T.C., Eissenberg, J.C., Craig, C., Dietrich, V., Hobson, A. and Elgin, S.C. (1989) Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila. Eur. J. Cell. Biol., 50, 170-180.
    • (1989) Eur. J. Cell. Biol. , vol.50 , pp. 170-180
    • James, T.C.1    Eissenberg, J.C.2    Craig, C.3    Dietrich, V.4    Hobson, A.5    Elgin, S.C.6
  • 6
    • 0034624985 scopus 로고    scopus 로고
    • The fourth chromosome of Drosophila melanogaster interspersed euchromatic and heterochromatic domains
    • Sun, F.L., Cuaycong, M.H., Craig, C.A., Wallrath, L.L., Locke, J. and Elgin, S.C. (2000) The fourth chromosome of Drosophila melanogaster interspersed euchromatic and heterochromatic domains. Proc. Natl. Acad. Sci. USA, 97, 5340-5345.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5340-5345
    • Sun, F.L.1    Cuaycong, M.H.2    Craig, C.A.3    Wallrath, L.L.4    Locke, J.5    Elgin, S.C.6
  • 8
    • 0032215539 scopus 로고    scopus 로고
    • The heterochromatin protein 1 prevents telomere fusions in Drosophila
    • Fanti, L., Giovinazzo, G., Berloco, M. and Pimpinelli, S. (1998) The heterochromatin protein 1 prevents telomere fusions in Drosophila. Mol. Cell, 2, 527-528.
    • (1998) Mol. Cell , vol.2 , pp. 527-528
    • Fanti, L.1    Giovinazzo, G.2    Berloco, M.3    Pimpinelli, S.4
  • 9
    • 34250151584 scopus 로고
    • Genes which suppress position-effect variegation in Drosophila Melanogaster are clustered
    • Sinclair, D.A.R., Mottus, R.C. and Grigliatti, T.A. (1983) Genes which suppress position-effect variegation in Drosophila Melanogaster are clustered. Mol. Gen. Genet., 191, 326-333.
    • (1983) Mol. Gen. Genet. , vol.191 , pp. 326-333
    • Sinclair, D.A.R.1    Mottus, R.C.2    Grigliatti, T.A.3
  • 10
    • 0025600929 scopus 로고
    • Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster
    • Eissenberg, J.C., James, T.C., Foster-Hartnett, D.M., Hartnett, T., Ngan, V. and Elgin, S.C. (1990) Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA, 87, 9923-9927.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9923-9927
    • Eissenberg, J.C.1    James, T.C.2    Foster-Hartnett, D.M.3    Hartnett, T.4    Ngan, V.5    Elgin, S.C.6
  • 11
    • 0026632337 scopus 로고
    • The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation
    • Eisenberg, J.C., Morris, G.D., Reuter, G. and Hartnett. T. (1992) The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation. Genetics, 131, 345-352.
    • (1992) Genetics , vol.131 , pp. 345-352
    • Eisenberg, J.C.1    Morris, G.D.2    Reuter, G.3    Hartnett, T.4
  • 12
    • 0026098009 scopus 로고
    • The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila
    • Paro, R. and Hogness, D.S. (1991) The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc. Natl Acad. Sci. USA, 88, 263-267.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 263-267
    • Paro, R.1    Hogness, D.S.2
  • 13
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner, M., O'Carroll, D,. Rea, S., Mechtler, K. and Jenuwein, T. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature, 410, 116-120.
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 15
    • 0036499971 scopus 로고    scopus 로고
    • Central role of Drosophila Su(var)3-9 in histone H3-K9 methylation and heterochromatic gene silencing
    • Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J.E., Rea, S., Jenuwein, T., Dorn, R. and Reuter, G. (2002) Central role of Drosophila Su(var)3-9 in histone H3-K9 methylation and heterochromatic gene silencing EMBO J., 21, 1121-1131.
    • (2002) EMBO J. , vol.21 , pp. 1121-1131
    • Schotta, G.1    Ebert, A.2    Krauss, V.3    Fischer, A.4    Hoffmann, J.E.5    Rea, S.6    Jenuwein, T.7    Dorn, R.8    Reuter, G.9
  • 16
    • 0037154972 scopus 로고    scopus 로고
    • Epigenetic codes for heterochromatin formation and silencing: Rounding up the usual suspects
    • Richards, E.J. and Elgin, S.C. (2002) Epigenetic codes for heterochromatin formation and silencing: Rounding up the usual suspects. Cell, 108, 489-500.
    • (2002) Cell , vol.108 , pp. 489-500
    • Richards, E.J.1    Elgin, S.C.2
  • 17
    • 0034531519 scopus 로고    scopus 로고
    • The genomic silencing of position-effect variegation in Drosophila melanogaster: Interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1
    • Delattre, M., Spierer, A., Tonka, C.H. and Spierer, P. (2000) The genomic silencing of position-effect variegation in Drosophila melanogaster: Interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1. J. Cell Sci., 113, 4253-4261.
    • (2000) J. Cell Sci. , vol.113 , pp. 4253-4261
    • Delattre, M.1    Spierer, A.2    Tonka, C.H.3    Spierer, P.4
  • 18
    • 0037079677 scopus 로고    scopus 로고
    • Functional and physical interaction between the histone methyltransferase Suv39H1 and histone deacetylases
    • Vaute, O., Nicolas, E., Vandel, L. and Trouche, D. (2002) Functional and physical interaction between the histone methyltransferase Suv39H1 and histone deacetylases. Nucleic Acids Res., 30, 475-481.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 475-481
    • Vaute, O.1    Nicolas, E.2    Vandel, L.3    Trouche, D.4
  • 22
    • 0034623161 scopus 로고    scopus 로고
    • Heterochromatin protein 1 binds to nucleosomes and DNA in vitro
    • Zhao, T., Heyduk, T, Allis, C.D. and Eissenberg, J.C. (2000) Heterochromatin protein 1 binds to nucleosomes and DNA in vitro. J. Biol. Chem., 275, 28332-28338.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28332-28338
    • Zhao, T.1    Heyduk, T.2    Allis, C.D.3    Eissenberg, J.C.4
  • 24
    • 0037238178 scopus 로고    scopus 로고
    • HP1 complexes and heterochromatin assembly
    • Kellum, R. (2003) HP1 complexes and heterochromatin assembly. Curr. Top. Microbiol. Immunol., 274, 53-77.
    • (2003) Curr. Top. Microbiol. Immunol. , vol.274 , pp. 53-77
    • Kellum, R.1
  • 25
    • 0029120080 scopus 로고
    • The chromodomain protein Swi6: A key component at fission yeast centromeres
    • Ekwall, K., Javerzat, J.P., Lorentz, A., Schmidt, H., Cranston, G. and Allshire, R. (1995) The chromodomain protein Swi6: A key component at fission yeast centromeres. Science, 269, 1429-1431.
    • (1995) Science , vol.269 , pp. 1429-1431
    • Ekwall, K.1    Javerzat, J.P.2    Lorentz, A.3    Schmidt, H.4    Cranston, G.5    Allshire, R.6
  • 27
    • 0028947197 scopus 로고
    • Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos
    • Kellum, R. and Alberts, B.M. (1995) Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos. J. Cell Sci., 108, 1419-1431.
    • (1995) J. Cell Sci. , vol.108 , pp. 1419-1431
    • Kellum, R.1    Alberts, B.M.2
  • 29
    • 0031080378 scopus 로고    scopus 로고
    • Analysis of chromatin structure by in vivo formaldehyde cross-linking
    • Orlando, V., Struat, H. and Paro, R. (1997) Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods, 11, 205-214.
    • (1997) Methods , vol.11 , pp. 205-214
    • Orlando, V.1    Struat, H.2    Paro, R.3
  • 30
    • 0038308585 scopus 로고    scopus 로고
    • Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation
    • Christensen, T.W. and Tye, B.K. (2003) Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. Mol. Biol. Cell, 14, 2206-2215.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2206-2215
    • Christensen, T.W.1    Tye, B.K.2
  • 31
    • 0030913801 scopus 로고    scopus 로고
    • Chromatin proteins involved in the initiation of DNA replication
    • Rowles, A. and Blow, J.J. (1997) Chromatin proteins involved in the initiation of DNA replication. Curr. Opin. Genet. Dev., 7, 152-157.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 152-157
    • Rowles, A.1    Blow, J.J.2
  • 32
    • 0842324624 scopus 로고    scopus 로고
    • MCM proteins: DNA damage, mutagenesis and repair
    • Bailis, J.M. and Forsburg, S.L. (2004) MCM proteins: DNA damage, mutagenesis and repair. Curr. Opin. Genet. Dev., 14, 17-21.
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 17-21
    • Bailis, J.M.1    Forsburg, S.L.2
  • 33
    • 0035252654 scopus 로고    scopus 로고
    • Chromosomal passengers and the (aurora) ABCs of mitosis
    • Adams, R.R., Carmena, M. and Earnshaw, W.C. (2001) Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol., 11, 49-54.
    • (2001) Trends Cell Biol. , vol.11 , pp. 49-54
    • Adams, R.R.1    Carmena, M.2    Earnshaw, W.C.3
  • 34
    • 0035844878 scopus 로고    scopus 로고
    • Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
    • Sharp-Baker, H. and Chen, R.H. (2001) Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J. Cell Biol., 153, 1239-1250.
    • (2001) J. Cell Biol. , vol.153 , pp. 1239-1250
    • Sharp-Baker, H.1    Chen, R.H.2
  • 35
    • 0033549477 scopus 로고    scopus 로고
    • Mutations in the essential spindle checkpoint gene bub 1 cause chromosome missegregation and fail to block apoptosis in Drosophila
    • Basu, J., Bousbaa, H.., Logarinho, E., Li, Z., Williams, B.C., Lopes, C., Sunkel, C.E. and Goldberg, M.L. (1999) Mutations in the essential spindle checkpoint gene bub 1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J. Cell Biol., 146, 13-28.
    • (1999) J. Cell Biol. , vol.146 , pp. 13-28
    • Basu, J.1    Bousbaa, H.2    Logarinho, E.3    Li, Z.4    Williams, B.C.5    Lopes, C.6    Sunkel, C.E.7    Goldberg, M.L.8
  • 36
    • 0035911159 scopus 로고    scopus 로고
    • Drosophila aurora B kinase is required for histone H3, phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
    • Giet, R. and Glover, D.M. (2001) Drosophila aurora B kinase is required for histone H3, phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J. Cell Biol., 152, 669-682.
    • (2001) J. Cell Biol. , vol.152 , pp. 669-682
    • Giet, R.1    Glover, D.M.2
  • 37
    • 0032498786 scopus 로고    scopus 로고
    • A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
    • Mackay, A.M., Ainztein, A.M., Eckley, D.M. and Earnshaw, W.C. (1998) A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis. J. Cell Biol., 140, 991-1002.
    • (1998) J. Cell Biol. , vol.140 , pp. 991-1002
    • Mackay, A.M.1    Ainztein, A.M.2    Eckley, D.M.3    Earnshaw, W.C.4
  • 39
    • 0034595448 scopus 로고    scopus 로고
    • Uninterrupted MCM2-7 function required for DNA replication fork progression
    • Labib, K., Tercero, J.A. and Diffley, J.F. (2000) Uninterrupted MCM2-7 function required for DNA replication fork progression. Science, 288, 1643-1647,
    • (2000) Science , vol.288 , pp. 1643-1647
    • Labib, K.1    Tercero, J.A.2    Diffley, J.F.3
  • 40
    • 0030722744 scopus 로고    scopus 로고
    • Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
    • Pak, D.T., Pflumm, M., Chesnokov, I., Huang, D.W., Kellum, R., Marr, J., Romanowski, P. and Botchan, M.R. (1997) Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell, 91, 311-323.
    • (1997) Cell , vol.91 , pp. 311-323
    • Pak, D.T.1    Pflumm, M.2    Chesnokov, I.3    Huang, D.W.4    Kellum, R.5    Marr, J.6    Romanowski, P.7    Botchan, M.R.8
  • 41
    • 0032572558 scopus 로고    scopus 로고
    • Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: Their phosphorylation levels and associations with origin recognition complex proteins
    • Huang, D.W., Fanti, L., Pak, D.T., Botchan, M.R., Pimpinelli, S. and Kellum, R. (1998) Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: Their phosphorylation levels and associations with origin recognition complex proteins. J. Cell Biol., 142, 307-318.
    • (1998) J. Cell Biol. , vol.142 , pp. 307-318
    • Huang, D.W.1    Fanti, L.2    Pak, D.T.3    Botchan, M.R.4    Pimpinelli, S.5    Kellum, R.6
  • 42
    • 0032576619 scopus 로고    scopus 로고
    • INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1
    • Ainsztein, A.M., Kandels-Lewis, S.E., Mackay, A.M. and Earnshaw, W.C. (1998) INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1. J. Cell Biol., 143, 1763-1774.
    • (1998) J. Cell Biol. , vol.143 , pp. 1763-1774
    • Ainsztein, A.M.1    Kandels-Lewis, S.E.2    Mackay, A.M.3    Earnshaw, W.C.4
  • 43
    • 0033582544 scopus 로고    scopus 로고
    • Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
    • Shibahara, K. and Stillman, B. (1999) Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Cell, 96, 575-585.
    • (1999) Cell , vol.96 , pp. 575-585
    • Shibahara, K.1    Stillman, B.2
  • 45
    • 0037847397 scopus 로고    scopus 로고
    • Effects of tethering HP1 to euchromatic regions of the Drosophila genome
    • Li, Y., Danzer, J.R., Alvarez, P., Belmont, A.S. and Wallrath, L.L. (2003) Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Development, 130, 1817-1824.
    • (2003) Development , vol.130 , pp. 1817-1824
    • Li, Y.1    Danzer, J.R.2    Alvarez, P.3    Belmont, A.S.4    Wallrath, L.L.5
  • 46
    • 0035949598 scopus 로고    scopus 로고
    • Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers
    • Hwang, K.K., Eissenberg, J.C. and Worman, H.J. (2001) Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proc. Natl Acad. Sci. USA, 98, 11423-11427.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11423-11427
    • Hwang, K.K.1    Eissenberg, J.C.2    Worman, H.J.3
  • 47
    • 0032144412 scopus 로고    scopus 로고
    • Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement
    • Clegg, N.J., Honda, B.M., Whitehead, I.P., Grigliatti, T.A., Wakimoto, B., Brock, H.W., Lloyd, V.K. and Sinclair, D.A. (1998) Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement. Genome, 41, 495-503.
    • (1998) Genome , vol.41 , pp. 495-503
    • Clegg, N.J.1    Honda, B.M.2    Whitehead, I.P.3    Grigliatti, T.A.4    Wakimoto, B.5    Brock, H.W.6    Lloyd, V.K.7    Sinclair, D.A.8
  • 48
    • 0026046642 scopus 로고
    • The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster
    • Hearn, M.G., Hedrick, A., Grigliatti, T.A. and Wakimoto, B.T. (1991) The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster. Genetics, 128, 785-797.
    • (1991) Genetics , vol.128 , pp. 785-797
    • Hearn, M.G.1    Hedrick, A.2    Grigliatti, T.A.3    Wakimoto, B.T.4
  • 49
    • 0034084365 scopus 로고    scopus 로고
    • Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila
    • Lu, B.Y., Emtage, P.C., Duyf, B.J., Hilliker, A.J. and Eissenberg, J.C. (2000) Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila. Genetics, 155, 699-708.
    • (2000) Genetics , vol.155 , pp. 699-708
    • Lu, B.Y.1    Emtage, P.C.2    Duyf, B.J.3    Hilliker, A.J.4    Eissenberg, J.C.5
  • 50
    • 0032076461 scopus 로고    scopus 로고
    • Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila
    • Wakimoto, B.T. (1998) Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila. Cell. 93, 321-324.
    • (1998) Cell , vol.93 , pp. 321-324
    • Wakimoto, B.T.1
  • 51
    • 0034026194 scopus 로고    scopus 로고
    • The HP1 protein family: Getting a grip on chromatin
    • Eissenberg, J.C. and Elgin, S.C. (2000) The HP1 protein family: Getting a grip on chromatin. Curr. Opin. Genet. Dev.. 10, 204-210.
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 204-210
    • Eissenberg, J.C.1    Elgin, S.C.2
  • 52
    • 0037648395 scopus 로고    scopus 로고
    • Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin
    • Piacentini, L., Fanti, L., Berloco, M., Perrini, B. and Pimpinelli, S. (2003) Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J. Cell Biol., 161, 707-714.
    • (2003) J. Cell Biol. , vol.161 , pp. 707-714
    • Piacentini, L.1    Fanti, L.2    Berloco, M.3    Perrini, B.4    Pimpinelli, S.5
  • 53
    • 0037684838 scopus 로고    scopus 로고
    • Is HP1 an RNA detector that functions both in repression and activation?
    • Kellum, R. (2003) Is HP1 an RNA detector that functions both in repression and activation? J. Cell Biol., 161, 671-672.
    • (2003) J. Cell Biol. , vol.161 , pp. 671-672
    • Kellum, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.