HP1: Facts, open questions, and speculation

Journal of Structural Biology

Volumn 140, Issue 1-3, 2002, Pages 10-16

  Singh, Prim B ^a   Georgatos, Spyros D ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Chromodomain proteins; Epigenetic regulation; Heterochromatin; Histones

Indexed keywords

HETEROCHROMATIN PROTEIN 1; HISTONE; PROTEIN; UNCLASSIFIED DRUG;

BIOLOGICAL MODEL; CELL COMPARTMENTALIZATION; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CONFERENCE PAPER; CROSS LINKING; HETEROCHROMATIN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; CIRCULAR DICHROISM; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HETEROCHROMATIN; HISTONES; MODELS, MOLECULAR; NUCLEAR ENVELOPE; PEPTIDES;

ACRONICTA LEPORINA;

EID: 0036966358     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1047-8477(02)00536-1     Document Type: Conference Paper

References (56)

1. Aagaard, I., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P.B., Reuter, G., Jenuwein, T., 1999. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18, 1923-1938.
2. Akhtar, A., Zink, D., Becker, P.B., 2000. Chromodomains are protein-RNA interaction modules. Nature 407, 405-409.
3. Anderssen, S.S., 1999. Balanced regulation of microtubule dynamics during the cell cycle: A contemporary view. Bioessays 21, 53-60.
4. Ball, L.J. et al., 1997. Structure of the chromatin-binding (chromo) domain from mouse modifier protein 1. EMBO J. 16, 2473-2481.
5. Bannister, A.J., Zegerman, P., Partridge, J.F., Miska, E.A., Thomas, J.O., Allshire, R.C., Kouzarides, T., 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124.
6. Brasher, S.V. et al., 2000. The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J. 19, 1587-1597.
7. Cleard, F., Delattre, M., Spierer, P., 1997. SU (VAR)3-7, a Drosophila hetrochromatin-associated protein and companion of HP1 in the genomic silencing of position-effecariegation. EMBO J. 16, 5280-5288.
8. Cowell, I.G. et al., 2001. Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma 111, 22-36.
9. Cowieson, N.P., Partridge, J.F., Allshire, R.C., McLaughlin, P.J., 2000. Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis. Curr. Biol. 10, 517-525.
10. Eissenberg, J.C., James, T.C., Foster-Hartnett, D.M., Hartnett, T., Ngan, V., Elgin, S.C., 1990. Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 87, 9923-9927.
11. Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., Singh, P., 1999. Heterochromatin protein 1 modifies mammalian PEV in a dose-and chromosomal-context dependent manner. Nature Genet. 23, 457-461.
12. Filesi, I., Cardinale, A., van der Sar, S., Cowell, I.G., Singh, P.B., Biocca, S., 2002. Loss of heterochromatin protein 1 (HP1) function in mammalian cells by intracellular antibodies causes cell death. J. Cell Sci. 115, 1803-1813.
13. Francastel, C., Schubeler, D., Martin, D.I., Groudine, M., 2000. Nuclear compartmentalisation and gene activity. Nature Mol. Cell Biol. 1, 137-143.
14. Hearn, M.G., Hedrick, A., Grigliatti, T.A., Wakimoto, B.T., 1991. The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster. Genetics 128, 785-797.
15. Horsley, D., Hutchings, A., Butcher, G.W., Singh, P.B., 1996. M32, a murine homologue of Drosophila heterochromatin protein 1 (HP1), localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin. Cytogenet. Cell Genet. 73, 308-311.
16. Huang, D.W., Fanti, L., Pak, D.T., Botchan, M.R., Pimpinelli, S., Kellum, R., 1998. Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: Their phosphorylation levels and associations with origin recognition complex proteins. J. Cell Biol. 142, 307-318.
17. Hwang, K.K., Eissenberg, J.C., Worman, H.J., 2001. Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proc. Natl. Acad. Sci. USA 98, 11423-11427.
18. Hwang, K.K., Worman, H.J., 2002. Gene regulation by human orthologs of Drosophila heterochromatin protein 1. Biochem. Biophys. Res. Commun. 293, 1217-1222.
19. Jacobs, S.A., Taverna, S.D., Zhang, Y., Briggs, S.D., Li, J., Eissenberg, J.C., Allis, C.D., Khorasanizadeh, S., 2001. Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J. 20, 5232-5241.
20. Jacobs, S.A., Khorasanizadeh, S., 2002. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science 295, 2080-2083.
21. James, T.C., Elgin, S.C., 1986. A nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol. Cell Biol., 3862-3872.
22. Jones, D.O., Cowell, I.G., Singh, P.B., 2000. Mammalian chromodomain proteins: Their role in genome organisation and expression. Bioessays 22, 124-137.
23. Kourmouli, N., Theodoropoulos, P.A., Dialynas, G., Bakou, A., Politou, A.S., Cowell, I.G., Singh, P.B., Georgatos, S.D., 2000. Dynamic associations of heterochromatin protein 1 with the nuclear envelope. EMBO J. 19, 6558-6568.
24. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., Jenuwein, T., 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120.
25. Lechner, M.S., Begg, G.E., Speicher, D.W., Rauscher III, F.J., 2000. Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol. Cell Biol. 20, 6449-6465.
26. LeDouarin, B., Nielsen, A.L., Garnier, J.M., Ichinose, H., Jeanmougin, F., Losson, R., Chambon, P., 1996. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 15, 6701-6715.
27. Lehming, N., Le Saux, A., Schuller, I., Ptashne, M., 1998. Chromatin components as part of a putative transcriptional repressing complex. Proc. Natl. Acad. Sci. USA 95, 7322-7326.
28. Lu, B.Y., Emtage, P.C., Duyf, B.J., Hilliker, A.J., Eissenberg, J.C., 2000. Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila. Genetics 155, 699-708.
29. Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., Richmond, T.J., 1997. Crystal structure of the nucleosome particle at 2.8 A resolution. Nature 389, 251-260.
30. Maison, C., Bailly, D., Peters, H.E.M., Quivy, J.-P., Roche, D., Taddei, A., Jenuwein, T., Almouzni, G., 2002. Higher order structure in pericentric heterochrmatin involves a distinct pattern of histone modification and an RNA component. Nature Genet. 30, 329-334.
31. Minc, E., Allory, Y., Worman, H.J., Courvalin, J.C., Buendia, B., 1999. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. Chromosoma 108, 220-234.
32. Minc, E., Courvalin, J.C., Buendia, B., 2000. HP1γ associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes. Cytogenet. Cell Genet. 90, 279-284.
33. Nakayama, J., Rice, J.C., Strahl, B.D., Allis, C.D., Grewal, S.I., 2001. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110-113.
34. Nielsen, A.L., Ortiz, J.A., You, J., Oulad-Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P., Losson, R., 1999. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 18, 6385-6395.
35. Nielsen, A.L., Oulad-Abdelghani, M., Ortiz, J.A., Remboutsika, E., Chambon, P., Losson, R., 2001a. Heterochromatin formation in mammalian cells: Interaction between histones and HP1 proteins. Mol. Cell. 7, 729-739.
36. Nielsen, S.J., Schneider, R., Bauer, U.M., Bannister, A.J., Morrison, A., O'Carroll Firestein, R., Cleary, M., Jenuwein, T., Herrere, R.E., Kouzarides, T., 2001b. Rb targets histone H3 methylation and HP1 to promoters. Nature 412, 561-565.
37. Nielsen, P.R., Nietlispach, D., Mott, H.R., Callaghan, J., Bannister, A., Kouzaridw Mursin, A.G., Murzina, N.V., Laue, E.D., 2002. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature 416, 103-107.
38. Nielsen, S.J., Schneider, R., Bauer, U.M., Bannister, A.J., Morrison, A., O'Carroll, D., Firestein, R., Cleary, M., Jenuwein, T., Herrera, R.E., Kouzarides, T., 2001c. Rb targets histone H3 methylation and HP1 to promoters. Nature 412, 561-565.
39. Pak, D.T., Pflumm, M., Chesnokow, I., Huang, D.W., Kellum, R., Marr, J., Romanowski, P., Botchan, M.R., 1997. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell 91, 311-323.
40. Paro, R., Hogness, D.S., 1991. The Polycomb protein shares a homologous domain with heterochromatin-associated protein of Drosophila. Proc. Natl. Acad. Sci. USA 88, 263-267.
41. Peters, A.H.F.M., Mermoud, J.E., O'Carroll, D., Pagani, M., Schweizer, D., Brockdorff, N., Jenuwein, T., 2001. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nature Genet. 30, 77-80.
42. Polioudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P.A., Singh, P.B., Giannakouros, T., Georgatos, S.D., 2001. Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1. EMBO Rep. 2, 920-925.
43. Richards, E.J., Elgin, S.C., 2002. Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell. 108, 489-500.
44. Ryan, R.F., Schultz, D.C., Ayyanathan, K., Singh, P.B., Friedman, J.R., Fredericks, W.J., Rauscher III, F.J., 1999. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol. Cell Biol. 19, 4366-4378.
45. Scholzen, T., Endl, E., Wohlenberg, C., Van Der Sar, S., Cowell, I.G., Gerdes, J., Singh, P.B., 2002. The Ki-67 Protein interacts with members of the heterochrom: Protein 1 (HP1) family: A potential role in the regulation of higher order chromatin structure. J. Pathol. 196, 135-144.
46. Seeler, J.S., Marchio, A., Sitterlin, D., Transy, C., Dejean, A., 1998. Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc. Natl. Acad. Sci. USA 95, 7316-7321.
47. Shareef, M.M., King, C., Damaj, M., Badagu, R., Huang, D.W., Kellum, R., 2001. Drosophila heterochromatin protein 1 (HP1)/origin recognitior complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing. Mol. Biol. Cell 12, 1671-1685.
48. Singh, P.B., Huskisson, N.S., 1998. Chromatin complexes as aperiodic microcrystalline arrays that regulate genome organization and expression. Dev. Genet. 22, 85-99.
49. Singh, P.B., Miller, J.R., Pearce, J., Kothary, R., Burton, R.D., Paro, R., James, T.C., Gaunt, S.J., 1991. A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 19, 789-794.
50. Smothers, J.F., Henikoff, S., 2000. The HP1 chromo shadow domain binds a consensus peptide pentamer. Curr. Biol. 10, 27-30.
51. Song, K., Jung, Y., Jung, D., Lee, I., 2001. Human Ku70 interacts with heterochromatin protein 1α. J. Biol. Chem. 276, 8321-8327.
52. II 130. Proc. Natl. Acad. Sci. USA 99, 5919-5924.
53. Ye, Q., Callebaut, I., Pezhman, A., Courvalin, J.C., Worman, H.J., 1997. Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. J. Biol. Chem. 272, 14983-14989.
54. Ye, O., Worman, H.I., 1996. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologousto Drosophila HP1. J. Biol. Chem. 271, 14653-14656.
55. Wakimoto, B., Hearn, M.G., 1990. The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster. Genetics 125, 141-154.
56. Wang, G., Ma, A., Chow, C.M., Horsley, D., Brown, N.R., Cowell, I.G., Singh, P.B., 2000. Conservation of heterochromatin protein 1 function. Mol. Cell Biol. 20, 6970-6983.