Dissociation of I domain and global conformational changes in LFA-1: Refinement of small molecule-I domain structure-activity relationships

Biochemistry

Volumn 44, Issue 11, 2005, Pages 4322-4331

  Larson, Richard S ^a,d   Davis, Terry ^b   Bologa, Cristian ^c   Semenuk, Gloria ^a   Vijayan, Sreejith ^a   Li, Yu ^a   Oprea, Tudor ^c   Chigaev, Alexandre ^a   Buranda, Tione ^a   Wagner, Carston R ^b   Sklar, Larry A ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DERIVATIVES; DISSOCIATION; FLUORESCENCE; OPTIMIZATION; PHYSIOLOGICAL MODELS; SYNTHESIS (CHEMICAL);

DITHIOTHREITOL (DTT); FLOW CYTOMETERS; FLUORESCENT RESONANCE ENERGY TRANSFER (FRET); LIVE CELLS;

CONFORMATIONS;

1 (N FLUORESCEINYLTHIOUREIDOBUTYL)(4 BROMOBENZYL) 3 (3,5 DICHLOROPHENYL) 5 METHYLIMIDAZOLINE 2,4 DIONE; DITHIOTHREITOL; HYDANTOIN DERIVATIVE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MANGANESE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRAIN HL 60; CELL STRAIN U937; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; BINDING SITES; BINDING, COMPETITIVE; DITHIOTHREITOL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HL-60 CELLS; HUMANS; IMIDAZOLIDINES; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MANGANESE; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

EID: 20144366948     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048187k     Document Type: Article

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