A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function

Journal of Leukocyte Biology

Volumn 70, Issue 2, 2001, Pages 329-334

  Woska J R , Jr ^a   Shih, D T ^a   Taqueti, V R ^a   Hogg, N ^a   Kelly, T A ^a   Kishimoto, T K ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Adhesion molecules; Cell cell interactions; FACS; Inflammation; Integrin; mAb epitope

Indexed keywords

BIRT 377; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTAGONIST; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 24; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; BINDING AFFINITY; CELL ADHESION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; EPITOPE MAPPING; IMMUNE RESPONSE; IMMUNOREGULATION; INHIBITION KINETICS; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; REPORTER GENE;

ALLOSTERIC REGULATION; CELL ADHESION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; HUMANS; IMIDAZOLES; IMIDAZOLIDINES; IMMUNOSUPPRESSIVE AGENTS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEMBRANE GLYCOPROTEINS; PROTEIN CONFORMATION; TUMOR CELLS, CULTURED; UP-REGULATION;

ANIMALIA;

EID: 0034880897     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Adhesion receptors of the immune system
2. Structure and function of the leukocyte adhesion molecules CD11/CD18
3. Integrins, ICAMs, and selectins: Role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites
4. Clinical applications of antileukocyte adhesion molecule monoclonal antibodies
5. Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency
6. Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins
7. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumors
8. 2 integrin leukocyte function-associated antigen-1
9. Transendothelial migration and trafficking of leukocytes in LFA-1 deficient mice
10. Lymphocyte migration in lymphocyte function-associated antigen (LFA-1)-1-deficient mice
11. A small molecule antagonist of LFA-1-mediated cell adhesion
12. Leukocyte integrin activation
13. Activation of LFA-1: Role of cations
14. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
15. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes
16. Direct evidence for two affinity states for lymphocyte function-associated antigen-1 on activated T cells
17. The requirement for lymphocyte function-associated antigen-1 in homotypic leukocyte adhesion stimulated by phorbol ester
18. Identification of a cell surface protein complex mediating phorbol esterinduced adhesion (binding) among human mononuclear leukocytes
19. 2+ binding epitope on leukocyte integrin α subunits
20. Divalent cation regulation of the function of the leukocyte integrin LFA-1
21. T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1
22. KIM 185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR-3-dependent adhesion
23. Antibody against the Leu-CAM β-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events
24. Making a little affinity go a long way: A topological view of LFA-1 regulation
25. 2+-dependent protease, calpain
26. Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes
27. Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated antigen 1
28. A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection
29. Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: Evidence for the allosteric inhibition of a protein-protein interaction
30. A subpopulation of Mac-1 (CDllb/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
31. Folding of the N-terminal, ligand-binding region of integrin α-subunit into a β-propeller domain
32. The I domain of integrin leukocyte function-associated antigen-1 is involved in a conformational change leading to high affinity binding to ligand intercellular adhesion molecule 1 (ICAM-1)
33. 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1
34. Early events of the immune response mediated by leukocyte integrins
35. Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion
36. 1 integrins
37. 1 Integrin-dependent cell adhesion is regulated be a low affinity receptor pool that is conformationally responsive to ligand
38. 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium
39. 1 subunit
40. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers
41. 3 (platelet GPIlb-IIIa)
42. 1 chain
43. 1
44. Expression of ligand-induced binding sites on glycoprotein IIb/IIIa complexes and the effect of various inhibitors
45. 1 that inhibit allergic airway responses