Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: Implications for Smac-dependent anti-apoptotic activity of ML-IAP

Biochemical Journal

Volumn 385, Issue 1, 2005, Pages 11-20

  Vucic, Domagoj ^a   Franklin, Matthew C ^a   Wallweber, Heidi J A ^a   Das, Kanad ^a   Eckelman, Brendan P ^b,c   Shin, Hwain ^b,d   Elliott, Linda O ^a   Kadkhodayan, Saloumeh ^a   Deshayes, Kurt ^a   Salvesen, Guy S ^c   Fairbrother, Wayne J ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BURNHAM INSTITUTE   (United States)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Apoptosis; Inhibitor of apoptosis (IAP); Melanoma inhibitor of apoptosis (ML IAP); Smac DIABLO (second mitochondrial activator of caspases direct IAP binding protein with low pI); X linked IAP (XIAP)

Indexed keywords

AMINO ACIDS; MUTAGENESIS; SUBSTITUTION REACTIONS;

CASPASES; DISRUPTION; MELONOMA INHIBITOR OF APOPTOSIS (ML-IAP); PRO-APOPTOTIC STIMULI;

ENZYME INHIBITION;

CASPASE 3; CASPASE 9; INHIBITOR OF APOPTOSIS PROTEIN; MELANOMA INHIBITOR OF APOPTOSIS PROTEIN; MUTANT PROTEIN; PEPTIDE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CELL STRAIN MCF 7; CHIMERA; COMPLEX FORMATION; CRYSTAL STRUCTURE; EMBRYO; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SURFACE PLASMON RESONANCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; APOPTOSIS; BINDING SITES; CARRIER PROTEINS; CASPASE 9; CASPASES; CELL LINE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT FUSION PROTEINS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

ESCHERICHIA COLI; MINK CELL FOCUS-FORMING VIRUS; UNIDENTIFIED BACULOVIRUS;

EID: 19944431887     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041108     Document Type: Article

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