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Volumn 25, Issue 3, 1998, Pages 215-223

Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT(1A) receptor radioligand, [carbonyl-11C]WAY- 100635 - Explanation of high signal contrast in PET and an aid to biomathematical modelling

(13) Osman, Safiye a Lundkvist, Camilla b Pike, Victor W a Halldin, Christer b McCarron, Julie A a Swahn, Carl Gunnar b Farde, Lars b Ginovart, Nathalie b Luthra, Sajinder K a Gunn, Roger N a Bench, Christopher J a,c Sargent, Peter A a Grasby, Paul M a

a HAMMERSMITH HOSPITAL (United Kingdom)

b KAROLINSKA INSTITUTE (Sweden)

c IMPERIAL COLLEGE SCHOOL OF MEDICINE (United Kingdom)

Author keywords

5 HT(1A) receptor; carbonyl 11C WAY 100635; Antagonist; Human brain; PET; Radioactive metabolites

Indexed keywords

CARBON 11; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTRAST ENHANCEMENT; DRUG METABOLISM; DRUG RECEPTOR BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; MATHEMATICAL MODEL; MONKEY; NONHUMAN; NORMAL HUMAN; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; RAPHE NUCLEUS; TEMPORAL CORTEX;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; HUMANS; MACACA FASCICULARIS; MALE; MODELS, BIOLOGICAL; MODELS, THEORETICAL; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032053627 PISSN: 09698051 EISSN: None Source Type: Journal
DOI: 10.1016/S0969-8051(97)00206-0 Document Type: Article

Times cited : (90)

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