Development of orally active oxytocin antagonists: Studies on 1-(1-{4- [1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy].2methoxybenzoyl}- 4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines

Journal of Medicinal Chemistry

Volumn 41, Issue 12, 1998, Pages 2146-2163

  Bell, Ian M ^a   Erb, Jill M ^a   Freidinger, Roger M ^a   Gallicchio, Steven N ^a   Guare, James P ^a   Guidotti, Maribeth T ^a   Halpin, Rita A ^a   Hobbs, Doug W ^a   Homnick, Carl F ^a   Kuo, Michelle S ^a   Lis, Edward V ^a   Mathre, David J ^a   Michelson, Stuart R ^a   Pawluczy, Joseph M ^a   Pettibone, Douglas J ^a   Reiss, Duane R ^a   Vickers, Stanley ^a   Williams, Peter D ^a   Woyden, Carla J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [1 [4 (1 ACETYL 4 PIPERIDINYLOXY) 2 METHOXYBENZOYL] 4 PIPERIDINYL]BENZ[D][1,3]OXAZIN 2 ONE; 1 [1 [4 (3 ACETAMIDOPROPOXY)BENZOYL] 4 PIPERIDYL] 1,2,3,4 TETRAHYDRO 2 QUINOLINONE; 1 [1 [4 [1 (2 METHYL 1 OXIDOPYRIDIN 3 YLMETHYL)PIPERIDIN 4 YLOXY] 2 METHOXYBENZOYL]PIPERIDIN 4 YL] 1,4 DIHYDROBENZ[D][1,3]OXAZIN 2 ONE; 1 [[[2 [2 AMINO 4 (METHYLSULFONYL)BUTYRAMIDO] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 1 YL]METHYL]SULFONYL] 4 (2 METHYLPHENYL)PIPERAZINE; 1,4 DIHYDRO 1 [1 [2 METHOXY 4 (4 PIPERIDINYLOXY)BENZOYL] 4 PIPERIDINYL]BENZ[D][1,3]OXAZIN 2 ONE; 1,4 DIHYDRO 1 [1 [2 METHOXY 4 [1 (3 PYRIDINYLMETHYL) 4 PIPERIDINYLOXY]BENZOYL] 4 PIPERIDINYL]BENZ[D][1,3]OXAZIN 2 ONE; ATOSIBAN; OXYTOCIN ANTAGONIST; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HYDROXYLATION; DRUG POTENCY; DRUG SOLUBILITY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PREMATURE LABOR; RAT; UTERUS CONTRACTION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; HUMANS; KIDNEY; LIVER; MALE; MASS SPECTROMETRY; OXAZINES; PREGNANCY; PYRIDINES; RATS; RECEPTORS, OXYTOCIN; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; UTERINE CONTRACTION; UTERUS;

EID: 15644378251     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9800797     Document Type: Article

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