Synthesis and in vitro and in vivo functional studies of Ortho- substituted phenylpiperazine and N-substituted 4-N-(o- methoxyphenyl)aminopiperidine analogues of WAY100635

Journal of Medicinal Chemistry

Volumn 43, Issue 3, 2000, Pages 432-439

  Mensonides Harsema, Marguérite M ^a   Liao, Yi ^a   Böttcher, Henning ^b   Bartoszyk, Gerd D ^b   Greiner, Hartmunt E ^b   Harting, Jürgen ^b   De Boer, Peter ^c   Wikström, Håkan V ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b MERCK KGAA   (Germany)

^c PRA International USA   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; POSTSYNAPTIC RECEPTOR; SEROTONIN 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOTHERMIA; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; VOCALIZATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMINOPYRIDINES; ANIMALS; FRONTAL LOBE; GUINEA PIGS; HYPOTHERMIA; ILEUM; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERAZINES; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; ULTRASONICS; VOCALIZATION, ANIMAL;

EID: 0034628450     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991088y     Document Type: Article

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