Saccharomyces cerevisiae TSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex

Current Genetics

Volumn 47, Issue 5, 2005, Pages 273-288

  Ho, Hsiang Ling ^a   Shiau, Yu Shih ^a   Chen, Mei Yu ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Actin; Cell wall; Multicopy suppressor; Protein kinase C; Target of rapamycin

Indexed keywords

PROTEIN AVO1P; PROTEIN AVO2P; PROTEIN LST8P; PROTEIN TOR2; SACCHAROMYCES CEREVISIAE PROTEIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; ACTIN; AVO1 PROTEIN, S CEREVISIAE; AVO2 PROTEIN, S CEREVISIAE; CAFFEINE; CARRIER PROTEIN; CELL CYCLE PROTEIN; MULTIPROTEIN COMPLEX; OXIDOREDUCTASE; PHOSPHATIDYLINOSITOL 3 KINASE; SLM1 PROTEIN, S CEREVISIAE; TOR2 PROTEIN, S CEREVISIAE; TSC13 PROTEIN, S CEREVISIAE;

ALLELE; ANIMAL CELL; ARTICLE; AVO1 GENE; AVO2 GENE; AVO3 GENE; CELL WALL; FUNGAL GENE; GENE DOSAGE; GENE FUNCTION; GENOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PKC1 GENE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SLM1 GENE; TEMPERATURE SENSITIVE MUTANT; TSC11 GENE; YEAST CELL; CYTOLOGY; CYTOSKELETON; GENETICS; GROWTH, DEVELOPMENT AND AGING; LETHAL GENE; METABOLISM; MOLECULAR GENETICS; MUTATION; SIGNAL TRANSDUCTION; SUPPRESSOR GENE;

SACCHAROMYCES CEREVISIAE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ALLELES; BASE SEQUENCE; CAFFEINE; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL WALL; CYTOSKELETON; GENE DOSAGE; GENES, LETHAL; GENES, SUPPRESSOR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTATION; OXIDOREDUCTASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 19444376122     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-005-0570-8     Document Type: Article

References (63)

1. Andrews PD, Stark MJ (2000) Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J Cell Sci 113:507-520
2. Audhya A, et al (2004) Genome-wide lethality screen identifies new PI4,5P(2) effectors that regulate the actin cytoskeleton. EMBO J 23:3747-3757
3. Barbet N, et al (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7:25-42
4. 2+ sensitive csg2Δ mutant. J Biol Chem 273:30688-30694
5. Bickle M, Delley PA, Schmidt A, Hall MN (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17:2235-2245 10.1093/emboj/17.8.2235
6. Chai B, Hsu JM, Du J, Laurent BC (2002) Yeast RSC function is required for organization of the cellular cytoskeleton via an alternative PKC1 pathway. Genetics 161:575-584
7. Chen M-Y, Long Y, Devreotes PN (1997) A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the twelve transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev 11:3218-3231
8. Christianson TW, Skiorski RS, Dante M, Shero JH, Hieter P (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene 110:119-122
9. Costigan C, Gehrung S, Snyder M (1992) A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol Cell Biol 12:1162-1178
10. Fingar DC, Blenis J (2004) Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171
11. Firon A, Lesage G, Bussey H (2004) Integrative studies put cell wall synthesis on the yeast functional map. Curr Opin Microbiol 7:617-623
12. Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ (1998) Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif. J Biol Chem 273:2698-2705
13. Garcia R, et al (2004) The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. J Biol Chem 279:15183-15195
14. Geitz D, St Jean A, Woods RA, Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20:1425 1:CAS:528:DyaK38XisV2mu7w%3D
15. Gustin MC, Albertyn J, Alexander M, Davenport K (1998) MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62:1264-1300 1:CAS:528:DyaK1MXhs1OnsQ%3D%3D
16. Hara K, et al (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110:177-189
17. Heinisch JJ, Lorberg A, Schmitz HP, Jacoby JJ (1999) The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol Microbiol 32:671-680
18. Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909
19. Helliwell SB, et al (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell 5:105-118
20. Helliwell SB, Howald I, Barbet N, Hall MN (1998a) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148:99-112
21. Helliwell SB, Schmidt A, Ohya Y, Hall MN (1998b) The Rho1 effector, Pkc1, but not Bni1, mediates signaling from Tor2 to the actin cytoskeleton. Curr Biol 8:1211-1214
22. Hilti N, Baumann D, Schweingruber A-M, Bigler P, Schweingruber ME (1999) Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe. Curr Genet 35:585-592
23. Igual JC, Johnson AL, Johnston LH (1996) Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J 15:5001-5013
24. Jacinto E, et al (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6:1122-1128
25. Kaeberlein M, Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160:83-95
26. Kamada Y, et al (1996) Activation of yeast protein kinase C by Rho1 GTPase. J Biol Chem 271:9193-9196
27. Karpova TS, Lepetit MM, Cooper JA (1993) Mutations that enhance the cap2 null mutant phenotype in Saccharomyces cerevisiae affect the actin cytoskeleton, morphogenesis and pattern of growth. Genetics 135:693-709
28. Ketela T, Green R, Bussey H (1999) Saccharomyces cerevisiae Mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181:3330-3340
29. Kim DH, et al (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175 10.1016/S0092-8674(02)00808-5
30. Kim DH, et al (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11:895-904
31. Kunz J, et al (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73:585-596
32. Lagorce A, et al (2003) Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem 278:20345-20357
33. Lin J-J, Zakian VA (1996) The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc Natl Acad Sci USA 93:13760-13765
34. Loewith R, et al (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10:457-468 10.1016/S1097-2765(02)00636-6
35. Lorenz M.C. et al 1995 Gene disruption with PCR products in Saccharomyces cerevisiae. Gene 158:113-117 10.1016/0378-1119(95)00144-U
36. Marchler-Bauer A, et al (2005) CDD: A conserved domain database for protein classification. Nucleic Acids Res 33:D192-D196
37. Marchler-Bauer A, Bryant SH (2004) CD-Search: Protein domain annotations on the fly. Nucleic Acids Res 32:W327-W331
38. Martin H, et al (1996) Molecular and functional characterization of a mutant allele of the mitogen-activated protein-kinase gene SLT2 (MPK1) rescued from yeast autolytic mutants. Curr Genet 29:516-522
39. Martin H, Rodriguez-Pachon JM, Ruiz C, Nombela C, Molina M (2000) Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae. J Biol Chem 275:1511-1519
40. Mazur P, Baginsky W (1996) In vitro activity of 1,3-beta-d-glucan synthase requires the GTP-binding protein Rho1. J Biol Chem 271:14604-14609
41. Muhlrad D, Hunter R, Parker R (1992) A rapid method for localized mutagenesis of yeast genes. Yeast 8:79-82
42. Mumberg D, Muller R, Funk M (1994) Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res 22:5767-5768
43. Nickas ME, Yaffe MP (1996) BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae. Mol Cell Biol 16:258-2593
44. Nonaka H, et al (1995) A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J 14:5931-5938
45. Notredame C, Higgins D, Heringa J (2000) T-Coffee: A novel method for multiple sequence alignments. J Mol Biol 302:205-217 10.1006/ jmbi.2000.4042
46. Philip B, Levin DE (2001) Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1. Mol Cell Biol 21:271-280
47. Rajavel M, Philip B, Buehrer BM, Errede B, Levin DE (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19:3969-3976
48. Raught B, Gingras A-C, Sonenberg N (2001) The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA 98:7037-7044
49. J Sambrook DW Russell 2001 Molecular cloning: A laboratory manual, 3rd edn Cold Spring Harbor Laboratory Cold Spring Harbor, N.Y.
50. Sarbassov DD et al (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302 10.1016/ j.cub.2004.06.054
51. Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253-262
52. Schmidt A, Kunz J, Hall MN (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci USA 93:13780-13785
53. Schmidt A, Bickle M, Beck T, Hall MN (1997) The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88:531-542
54. Shamji AF, Kuruvilla FG, Schreiber SL (2000) Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol 10:1574-1581
55. Sikorski RS, Boeke JD (1991) In vitro mutagenesis and plasmid shuffling: from cloned genes to mutant yeast. Methods Enzymol 194:302-318
56. Sikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27 1:CAS:528:DyaL1MXktVais70%3D
57. Smith V, Chou KN, Lashkare D, Botstein D, Brown PO (1996) Functional analysis of the genes of yeast chromosome V by genetic footprinting. Science 274:2069-2074
58. Torres J, Di Como C.J., Herrero E, de la Torre-Ruiz M.A. 2002 Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast J Biol Chem 277 43495-43504
59. Uetz P, et al (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403:623-627 10.1038/ 35001009
60. Verna J, Lodder A, Lee K, Vagts A, Ballester R (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94:13804-13809
61. Wedaman KP, et al (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14:1204-1220
62. Yu JW, et al (2004) Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol Cell 13:677-688
63. Andrews PD, Stark MJ (2000) Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J Cell Sci 113:507-520