Sterically stabilized phospholipid mixed micelles: In vitro evaluation as a novel carrier for water-insoluble drugs

Pharmaceutical Research

Volumn 20, Issue 2, 2003, Pages 297-302

  Krishnadas, Aparna ^a   Rubinstein, Israel ^a,c   Önyüksel, Hayat ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Illinois at Chicago   (United States)

^c JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

Micelles; Paclitaxel; PEGylated lipids; Sterically stabilized crystals; Sterically stabilized micelles; Sterically stabilized mixed micelles; Water insoluble drugs

Indexed keywords

DISTEAROYLPHOSPHATIDYLETHANOLAMINE; DRUG CARRIER; ETHANOLAMINE DERIVATIVE; MACROGOL 2000; PACLITAXEL; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG SOLUBILITY; HUMAN; HUMAN CELL; PARTICLE SIZE; PRIORITY JOURNAL;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HUMANS; MICELLES; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS; SOLUBILITY; STEREOISOMERISM; TUMOR CELLS, CULTURED; WATER;

EID: 0037331217     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022243709003     Document Type: Article

References (21)

1. A. Wade and P. J. Weller. Handbook of Pharmaceutical Excipients, pp. 267-268, American Pharmaceutical Association & The Pharmaceutical Press, Washington, 1994.
2. P. K. Working and A. D. Dayan. Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl). Hum. Exp. Toxicol. 15:751-785 (1996).
3. A. Sharma, E. Mayhew, L. Bolcsak, C. Cavanaugh, P. Harmon, A. Janoff, and R. J. Bernacki. Activity of paclitaxel liposome formulations against human ovarian tumor xenografts. Int. J. Cancer 71:103-107 (1997).
4. A. Sharma and R. M. Straubinger. Novel taxol formulations: Preparation and characterization of taxol-containing liposomes. Pharm. Res. 11:889-896 (1994).
5. S. V. Balasubramanian, J. L. Alderfer, and R. M. Straubinger. Solvent- and concentration-dependent molecular interactions of taxol (Paclitaxel). J. Pharm. Sci. 83:1470-1476 (1994).
6. H. Alkan-Onyuksel and K. Son. Mixed micelles as proliposomes for the solubilization of teniposide. Pharm. Res. 9:1556-1562 (1992).
7. H. Alkan-Onyuksel, S. Ramakrishnan, H. B. Chai, and J. M. Pezzuto. A mixed micellar formulation suitable for the parenteral administration of taxol. Pharm. Res. 11:206-212 (1994).
8. A. K. Lukyanov, K. Whiteman, T. Levchenko, V. Weissig, A. Singhal, R. Ray, and V. Torchilin. Long-circulating therapeutic micelles from PE-PEG. Proceed. Int'l. Syrup. Control. Rel. Bioact. Mater. 28, pp. 466-467, Controlled Release Society, Inc. San Diego, California 2001.
9. H. Onyuksel, B. Ashok, and I. Rubinstein. Effect of PEG Chain Length on Size, CMC, and Solubilization Potential of Sterically Stabilized Phospholipid Micelles, in: 61st International Congress of FIP, pp. 82, Singapore, 2001.
10. V. P. Torchilin. Structure and design of polymeric surfactantbased drug delivery systems. J. Control. Release 73:137-172 (2001).
11. H. Onyuksel, H. Ikezaki, M. Patel, X. P. Gao, and I. Rubinstein. A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. Pharm. Res. 16:155-160 (1999).
12. V. Weissig, K. R. Whiteman, and V. P. Torchilin. Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice. Pharm. Res. 15:1552-1556 (1998).
13. J. M. Terwogt, B. Nuijen, W. W. Huinink, and J. H. Beijnen. Alternative formulations of paclitaxel. Cancer Treat. Rev. 23:87-95 (1997).
14. D. R. Kohler and B. R. Goldspiel. Paclitaxel (taxol). Pharmacotherapy 14:3-34 (1994).
15. L. van Zuylen, M. O. Karlsson, J. Verweij, E. Brouwer, P. de Bruijn, K. Nooter, G. Stoter, and A. Sparreboom. Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles. Cancer Chemother Pharmacol. 47:309-318 (2001).
16. A. L. Blajeski, T. J. Kottke, and S. H. Kaufmann. A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines. Exp. Cell Res. 270:277-288 (2001).
17. Y. Liu, S. M. Ali, T. C. Boge, G. I. Georg, S. Victory, J. Zygmunt, R. T. Marquez, and R. H. Himes. A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach. Comb. Chem. High Throughput Screen 5:39-48 (2002).
18. K. Likhitwitayawuid, C. K. Angerhofer, G. A. Cordell, J. M. Pezzuto, and N. Ruangrungsi. Cytotoxic and antimalarial bisben-zylisoquinoline alkaloids from Stephania erecta. J. Nat. Prod. 56:30-38 (1993).
19. S. Rex, M. J. Zuckermann, M. Lafleur, and J. R. Silvius. Experimental and Monte Carlo simulation studies of the thermodynamics of polyethyleneglycol chains grafted to lipid bilayers. Biophys. J. 75:2900-2914 (1998).
20. S. Belsito, R. Bartucci, and L. Sportelli. Lipid chain length effect on the phase behaviour of PCs/PEG:2000-PEs mixtures. A spin label electron spin resonance and spectrophotometric study. Biophys. Chem. 93:11-22 (2001).
21. R.M. Straubinger. In: M. Suffness (ed.) Taxol Science and Applications, pp. 237-258, CRC Press, New York, 1995.