Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781

International Journal of Pharmaceutics

Volumn 234, Issue 1-2, 2002, Pages 113-119

  Deferme, S ^a   Van Gelder, J ^a   Ingels, F ^a   Van Den Mooter, G ^a   De Buck, S ^a   Balzarini, J ^b   Naesens, L ^b   De Clercq, E ^b   Kinget, R ^a   Augustijns, P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Caco 2; Gelucire; HIV; NNRTI; UC 781; Vitamin E TPGS

Indexed keywords

ALPHA TOCOPHEROL; GELUCIRE; N [4 CHLORO 3 (3 METHYL 2 BUTENYLOXY)PHENYL] 2 METHYL 3 FURANCARBOTHIOAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOLUTION; DRUG ABSORPTION; DRUG CLASSIFICATION; DRUG DEGRADATION; DRUG PENETRATION; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANILIDES; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; FURANS; HUMANS; INTESTINAL ABSORPTION; MALE; MICRODIALYSIS; PERFUSION; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE INHIBITORS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0037006601     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00952-8     Document Type: Article

References (8)

1. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
2. In vitro, ex vivo and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil
3. The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds
4. The thiocarboxanilides UC-10 and UC-781 have an additive inhibitory effect against human immunodeficiency virus type 1 reverse transcriptase and replication in cell culture when combined with other antiretroviral drugs
5. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent
6. Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infecion: Retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase
7. The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3′-azido-3′-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1
8. Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection