Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: Effect of the particle size and nutritional state

Journal of Controlled Release

Volumn 68, Issue 2, 2000, Pages 291-298

  De Jaeghere, F ^a   Allemann E ^a   Kubel, F ^a   Galli, B ^b   Cozens, R ^b   Doelker, E ^a   Gurny, R ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

HIV 1 protease inhibitor; Methacrylic acid copolymer; Microparticle; Nanoparticle; Oral bioavailability; pH sensitive particles; Poorly water soluble drug

Indexed keywords

CGP 70726; EUDRAGIT; HYDROXYPROPYLCELLULOSE; MICROSPHERE; NANOPARTICLE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISPERSION; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; FEMALE; MALE; NONHUMAN; NUTRITIONAL STATUS; PARTICLE SIZE; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; X RAY ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BIPHENYL COMPOUNDS; DOGS; FEMALE; HIV PROTEASE; HIV PROTEASE INHIBITORS; HYDROGEN-ION CONCENTRATION; MALE; NUTRITIONAL STATUS; PARTICLE SIZE; SOLUBILITY; X-RAY DIFFRACTION;

EID: 0343953614     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00272-8     Document Type: Article

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