Biodegradable nanoparticle mediated antigen delivery to human cord blood derived dendritic cells for induction of primary T cell responses

Journal of Drug Targeting

Volumn 11, Issue 8-10, 2003, Pages 495-507

  Diwan, Manish ^a   Elamanchili, Praveen ^a   Lane, Helena ^a   Gainer, Anita ^a   Samuel, John ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Antigen delivery; CD34+ stem cells; CpG ODN; In vitro immunization; MPLA; Primary immune response

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; CD11 ANTIGEN; CD34 ANTIGEN; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE RECEPTOR CCR7; COPOLYMER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUCIN 1; NANOPARTICLE; OLIGONUCLEOTIDE; PHOSPHORYL LIPID A; POLYGLACTIN; TETANUS TOXOID; TOLL LIKE RECEPTOR 4;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; BIODEGRADABILITY; CANCER IMMUNIZATION; CELL CULTURE; CELL MATURATION; CELL SELECTION; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CPG ISLAND; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENCAPSULATION; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; GENE TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SCANNING ELECTRON MICROSCOPY; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

CA-15-3 ANTIGEN; CANCER VACCINES; DENDRITIC CELLS; DRUG CARRIERS; FETAL BLOOD; HUMANS; LACTIC ACID; LIPID A; NANOTECHNOLOGY; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDE FRAGMENTS; POLYGLYCOLIC ACID; POLYMERS; T-LYMPHOCYTES; TETANUS TOXOID;

EID: 1942539207     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860410001670026     Document Type: Review

References (75)

1. Agrawal, B., Gendler, S.J. and Longenecker, B.M. (1998a) "The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy", Mol. Med. Today 4, 397-403.
2. Agrawal, B., Krantz, M.J., Reddish, M.A. and Longenecker, B.M. (1998b) "Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2", Nat. Med. 4, 43-49.
3. Ahmad-Nejad, P., Hacker, H., Rutz, M., Bauer, S., Vabulas, R.M. and Wagner, H. (2002) "Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments", Eur. J. Immunol. 32, 1958-1968.
4. Antony, P.A. and Restifo, N.P. (2002) "Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?", J. Immunother. 25, 202-206.
5. Banchereau, J. and Steinman, R.M. (1998) "Dendritic cells and the control of immunity", Nature 392, 245-252.
6. Boes, M., Bertho, N., Cerny, J., Op den Brouw, M., Kirchhausen, T. and Ploegh, H. (2003) "T cells induce extended class II MHC compartments in dendritic cells in a toll-like receptor-dependent manner", J. Immunol. 171, 4081-4088.
7. Borras, F.E., Matthews, N.C., Patel, R. and Navarrete, C. (2000) "Dendritic cells can be successfully generated from CD34+ cord blood cells in the presence of autologous cord blood plasma", Bone Marrow Transplant. 26, 371-376.
8. Brossart, P., Wirths, S., Brugger, W. and Kanz, L. (2001) "Dendritic cells in cancer vaccines", Exp. Hematol. 29, 1247-1255.
9. Burgess, D.J., Hussain, A.S., Ingallinera, T.S. and Chen, M.L. (2002) "Assuring quality and performance of sustained and controlled release parenterals: AAPS workshop report, co-sponsored by FDA and USP", Pharm. Res. 19, 1761-1768.
10. Caux, C., Dezutter-Dambuyant, C., Schmitt, D. and Banchereau, J. (1992) "GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells", Nature 360, 258-261.
11. Caux, C., Liu, Y.J. and Banchereau, J. (1995) "Recent advances in the study of dendritic cells and follicular dendritic cells", Immunol. Today 16, 2-4.
12. Caux, C., Vanbervliet, B., Massacrier, C., Dezutter-Daimbuyant, C., de Saint-Vis, B., Jacquet, C., Yoneda, K., Imamura, S., Schmitt, D. and Banchereau, J. (1996) "CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+ TNF alpha", J. Exp. Med. 184, 695-706.
13. Coates, P.T. and Thomson, A.W. (2002) "Dendritic cells, tolerance induction and transplant outcome", Am. J. Transplant. 2, 299-307.
14. Davies, P. and Allison, A.C. (1978) "Effects of cytochalasin B on endocytosis and exocytosis", Front. Biol. 46, 143-160.
15. Dilioglou, S., Cruse, J.M. and Lewis, R.E. (2003) "Costimulatory function of umbilical cord blood CD14+ and CD34+ derived dendritic cells", Exp. Mol. Pathol. 75, 18-33.
16. Diwan, M., Dawar, H. and Talwar, G.P. (1998) "Induction of early and bioeffective antibody response in rodents with the luteinizing hormone-releasing hormone vaccine given as a single dose in biodegradable microspheres along with alum", Prostate 35, 279-284.
17. Diwan, M., Tafagodhi, M. and Samuel, J. (2002) "Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres", J. Control. Release 85, 247-262.
18. Domenech, E., Villen, E., Gonzalez-Barca, E., Querol, S., Garcia, J. and Rueda, F. (2000) "Serum-free culture conditions for the generation of dendritic cells from cord blood CD34+ hematopoietic progenitors: phenotypic and functional analysis", Haematologica 85, 989-990.
19. Enomoto, M., Nagayama, H., Sato, K., Xu, Y., Asano, S. and Takahashi, T.A. (2000) "In vitro generation of dendritic cells derived from cryopreserved CD34+ cells mobilized into peripheral blood in lymphoma patients", Cytotherapy 2, 95-104.
20. French, L.E. and Tschopp, J. (2002) "Defective death receptor signaling as a cause of tumor immune escape", Semin. Cancer Biol. 12, 51-55.
21. Gendler, S.J. (2001) "MUC1, the renaissance molecule", J. Mammary Gland Biol. Neoplasia 6, 339-353.
22. Gimmi, C.D., Morrison, B.W., Mainprice, B.A., Gribben, J.G., Boussiotis, V.A., Freeman, G.J., Park, S.Y., Watanabe, M., Gong, J., Hayes, D.F., Kufe, D.W. and Nadler, L.M. (1996) "Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells", Nat. Med. 2, 1367-1370.
23. Hacker, H. (2000) "Signal transduction pathways activated by CpG-DNA", Curr. Top. Microbiol. Immunol. 247, 77-92.
24. Hackstein, H., Morelli, A.E. and Thomson, A.W. (2001) "Designer dendritic cells for tolerance induction: guided not misguided missiles", Trends Immunol. 22, 437-442.
25. Hagihara, M., Li, C., Gansuvd, B., Munkhbat, B., Inoue, H., Shimakura, Y., Tsuchiya, T., Ueda, Y., Oki, M., Ando, K., Kato, S. and Hotta, T. (2001) "Extensive and long-term ex vivo production of dendritic cells from CD34 positive umbilical cord blood or bone marrow cells by novel culture system using mouse stroma", J. Immunol. Methods 253, 45-55.
26. Hart, D.N. (2001) "Dendritic cells and their emerging clinical applications", Pathology 33, 479-492.
27. Henderson, R.A., Konitsky, W.M., Barratt-Boyes, S.M., Soares, M., Robbins, P.D. and Finn, O.J. (1998) "Retroviral expression of MUC-1 human tumor antigen with intact repeat structure and capacity to elicit immunity in vivo", J. Immunother. 21, 247-256.
28. Horng, T., Barton, G.M., Flavell, R.A. and Medzhitov, R. (2002) "The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors", Nature 420, 329-333.
29. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S. and Hartmann, G. (2002) "Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides", J. Imnumol. 168, 4531-4537.
30. Ismaili, J., Rennesson, J., Aksoy, E., Vekemans, J., Vincart, B., Amraoui, Z., Van Laethem, F., Goldman, M. and Dubois, P.M. (2002) "Monophosphoryl lipid A activates both human dendritic cells and T cells", J. Immunol. 168, 926-932.
31. Janeway, C.A., Jr. and Medzhitov, R. (2002) "Innate immune recognition", Ann. Rev. Immunol. 20, 197-216.
32. Jeannon, J.P., Stafford, F.W., Soames, J.V. and Wilson, J.A. (2001) "Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer", Otolaryngol. Head Neck Surg. 124, 199-202.
33. Johansen, P., Men, Y., Merkle, H.P. and Gander, B. (2000) "Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination", Eur. J. Pharm. Biopharm. 50, 129-146.
34. Kadowaki, N., Ho, S., Antonenko, S., Malefyt, R.W., Kastelein, R.A., Bazan, F. and Liu, Y.J. (2001) "Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens", J. Exp. Med. 194, 863-869.
35. Kaisho, T. and Akira, S. (2001) "Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice", Trends Immunol. 22, 78-83.
36. Krieg, A.M. (2002) "CpG motifs in bacterial DNA and their immune effects", Ann. Rev. Immunol. 20, 709-760.
37. Krieg, A.M. (2003) "CpG motifs: the active ingredient in bacterial extracts?", Nat. Med. 9, 831-835.
38. Krug, A., Towarowski, A., Britsch, S., Rothenfusser, S., Hornung, V., Bals, R., Giese, T., Engelmann, H., Endres, S., Krieg, A.M. and Hartmann, G. (2001) "Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12", Eur. J. Immunol. 31, 3026-3037.
39. Lenert, P., Stunz, L., Yi, A.K., Krieg, A.M. and Ashman, R.F. (2001) "CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappa B activation", Antisense Nucleic Acid Drug. Dev. 11, 247-256.
40. Lipscomb, M.F. and Masten, B.J. (2002) "Dendritic cells: immune regulators in health and disease", Physiol. Rev. 82, 97-130.
41. Liu, A., Takahashi, M., Narita, M., Zheng, Z., Kanazawa, N., Abe, T., Nikkuni, K., Furukawa, T., Toba, K., Fuse, I. and Aizawa, Y. (2002) "Generation of functional and mature dendritic cells from cord blood and bone marrow CD34+ cells by two-step culture combined with calcium ionophore treatment", J. Immunol. Methods 261, 49-63.
42. Lu, L. and Thomson, A.W. (2002) "Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease", Transplantation 73, S19-S22.
43. Lutsiak, M.E., Robinson, D.R., Coester, C., Kwon, G.S. and Samuel, J. (2002) "Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro" , Pharm. Res. 19, 1480-1487.
44. Mahanty, S., Hutchinson, K., Agarwal, S., Mcrae, M., Rollin, P.E. and Pulendran, B. (2003) "Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses", J. Immunol. 170, 2797-2801.
45. Matsuda, K., Masaki, T., Watanabe, T., Kitayama, J., Nagawa, H., Muto, T. and Ajioka, Y. (2000) "Clinical significance of MUC1 and MUC2 mucin and p53 protein expression in colorectal carcinoma", Jap. J. Clin. Oncol. 30, 89-94.
46. McDermott, K.M., Crocker, P.R., Harris, A., Burdick, M.D., Hinoda, Y., Hayashi, T., Imai, K. and Hollingsworth, M.A. (2001) "Overexpression of MUC1 reconfigures the binding properties of tumor cells", Int. J. Cancer 94, 783-791.
47. Medzhitov, R. and Janeway, C.A., Jr (2002) "Decoding the patterns of self and nonself by the innate inumme system", Science 296, 298-300.
48. Moll, H. and Berberich, C. (2001) "Dendritic cells as vectors for vaccination against infectious diseases", Int. J. Med. Microbiol. 291, 323-329.
49. Moser, M. (2003) "Dendritic cells in immunity and tolerance-do they display opposite functions?", Immunity 19, 5-8.
50. Newman, K.D., Sosnowski, D.L., Kwon, G.S. and Samuel, J. (1998) "Delivery of MUC1 mucin peptide by Poly(D,L-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses", J. Pharm. Sci. 87, 1421-1427.
51. Newman, K.D., Elamanchili, P., Kwon, G.S. and Samuel, J. (2002) "Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo", J. Biomed. Mater. Res. 60, 480-486.
52. Obermair, A., Schmid, B.C., Packer, L.M., Leodolter, S., Birner, P., Ward, B.G., Crandon, A.J., McGuckin, M.A. and Zeillinger, R. (2002) "Expression of MUC1 splice variants in benign and malignant ovarian tumour", Int. J. Cancer 100, 166-171.
53. Pecher, G., Haring, A., Kaiser, L. and Thiel, E. (2002) "Mucin gene (MUC1) transfected dendritic cells as vaccine: results of a phase I/II clinical trial", Cancer Immunol. Immunother. 51, 669-673.
54. Probst, H.C., Lagnel, J., Kollias, G. and van den Broek, M. (2003) "Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance", Immunity 18, 713-720.
55. Reid, C.D., Fryer, P.R., Clifford, C., Kirk, A., Tikerpae, J. and Knight, S.C. (1990) "Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood", Blood 76, 1139-1149.
56. Reinhard, G., Marten, A., Kiske, S.M., Feil, F., Bieber, T. and Schmidt-Wolf, I.G. (2002) "Generation of dendritic cell-based vaccines for cancer therapy", Br. J. Cancer 86, 1529-1533.
57. Rougier, N., Redziniak, G., Schmitt, D. and Vincent, C. (1998) "Evaluation of the capacity of dendritic cells derived from cord blood CD34+ precursors to present haptens to unsensitized autologous T cells in vitro", J. Investig. Dermatol. 110, 348-352.
58. Sadanaga, N., Nagashima, H., Mashino, K., Tahara, K., Yamaguchi, H., Ohta, M., Fujie, T., Tanaka, F., Inoue, H., Takesako, K., Akiyoshi, T. and Mori, M. (2001) "Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas", Clin. Cancer Res. 7, 2277-2284.
59. Samuel, J., Budzynski, W.A., Reddish, M., Ding, L., Zimmermann, G., Krantz, M., Koganty, R.R. and Longenecker, B.M. (1998) "Immunogenicity and antitumor activity of a liposomal MUC1 peptide based vaccine", Int. J. Cancer 75, 295-302.
60. Singh, M. and O'Hagan, D.T. (2002) "Recent advances in vaccine adjuvants", Pharm. Res. 19, 715-728.
61. Sinha, V.R. and Trehan, A. (2003) "Biodegradable microspheres for protein delivery", J. Control. Release 90, 261-280.
62. Steinman, R.M. (1991) "The dendritic cell system and its role in immunogenicity", Annu. Rev. Immunol. 9, 271-296.
63. Steinman, R.M. and Dhodapkar, M. (2001) "Active immunization against cancer with dendritic cells: the near future", Int. J. Cancer 94, 459-473.
64. Stift, A., Friedl, J., Dubsky, P., Bachleitner-Hofmann, T., Schueller, G., Zontsich, T., Benkoe, T., Radelbauer, K., Brostjan, C., Jakesz, R. and Gnant, M. (2003) "Dendritic cell-based vaccination in solid cancer", J. Clin. Oncol. 21, 135-142.
65. Strunk, D., Rappersberger, K., Egger, C., Strobl, H., Kromer, E., Elbe, A., Maurer, D. and Stingl, G. (1996) "Generation of human dendritic cells/Langerhans cells from circulating CD34+ hematopoietic progenitor cells", Blood 87, 1292-1302.
66. Takeda, K., Kaisho, T. and Akira, S. (2003) "Toll-like receptors", Annu. Rev. Immunol. 21, 335-376.
67. Thomas, R. and Lipsky, P.E. (1994) "Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells", J. Immunol. 153, 4016-4028.
68. Verthelyi, D. and Zeuner, R.A. (2003) "Differential signaling by CpG DNA in DCs and B cells: not just TLR9", Trends Immunol. 24, 519-522.
69. Vicari, A.P., Caux, C. and Trinchieri, G. (2002) "Tumour escape from immune surveillance through dendritic cell inactivation" , Semin. Cancer Biol. 12, 33-42.
70. von Mensdorff-Pouilly, S., Snijdewint, F.G., Verstraeten, A.A., Verheijen, R.H. and Kenemans, P. (2000) "Human MUC1 mucin: a multifaceted glycoprotein", Int. J. Biol. Markers 15, 343-356.
71. Walter, E., Dreher, D., Kok, M., Thiele, L., Kiama, S.G., Gehr, P. and Merkle, H.P. (2001) "Hydrophilic poly(D,L-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells", J. Control. Release 76, 149-168.
72. Wang, L.R., Shi, B., Cui, J.Y., Han, S.X., Wang, S.W. and Chen, J.L. (2002) "Dendritic cells cultured with human umbilical cord serum instead of fetal calf serum", Zhongguo Shi Yan Xue Ye Xue Za Zhi 10, 236-239.
73. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K. and Akira, S. (2002) "Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4", Nature 420, 324-329.
74. Yao, V., Platell, C. and Hall, J.C. (2002) "Dendritic cells", A. N. Z. J. Surg. 72, 501-506.
75. Zhou, Y., Bosch, M.L. and Salgaller, M.L. (2002) "Current methods for loading dendritic cells with tumor antigen for the induction of antitumor immunity", J. Immunother. 25, 289-303.