Overexpression of MUC1 reconfigures the binding properties of tumor cells

International Journal of Cancer

Volumn 94, Issue 6, 2001, Pages 783-791

  McDermott, Kimberly M ^a   Crocker, Paul R ^a   Harris, Ann ^b   Burdick, Michael D ^b   Hinoda, Yuji ^c   Hayashi, Toshiaki ^d   Imai, Kohzoh ^e   Hollingsworth, Michael A ^a,f  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

Colon cancer; ICAM 1; Metastasis; Pancreatic cancer; Selectin

Indexed keywords

CD9 ANTIGEN; CHIMERIC PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HERMES ANTIGEN; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; MUCIN 1; PADGEM PROTEIN; SELECTIN; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL STRAIN CACO 2; CONTROLLED STUDY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GLYCOSYLATION; HUMAN; HUMAN CELL; METASTASIS; PANCREAS CANCER; PRIORITY JOURNAL; TANDEM REPEAT; TUMOR CELL;

AMINO ACID SEQUENCE; CA-15-3 ANTIGEN; CELL ADHESION; E-SELECTIN; GLYCOSYLATION; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; TANDEM REPEAT SEQUENCES; TUMOR CELLS, CULTURED;

EID: 0035892304     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1554     Document Type: Article

References (54)

1. Cloning and sequencing of a human pancreatic tumor mucin cDNA
2. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin
3. Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini
4. Human epithelial tumor antigen cDNA sequences: Differential splicing may generate multiple protein forms
5. Mucin genes and the proteins they encode: Structure, diversity, and regulation
6. Purification and characterization of a membrane-bound and a secreted mucin-type glycoprotein carrying the carcinoma-associated sialyl-Lea epitope on distinct core proteins
7. The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tail
8. Cell-associated episialin is a complex containing two proteins derived from a common precursor
9. Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma
10. Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies
11. Altered glycosylation of mucin glycoproteins in colonic neoplasia
12. A fucose residue can mask the MUC-1 epitopes in normal and cancerous gastric mucosae
13. Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression
14. Characterization of the major sialyl-Lex-positive mucins present in colon, colon carcinoma, and sera of patients with colorectal cancer
15. Heterogeneity of mucin gene expression in normal and neoplastic tissues
16. Association of sialyl-Lewis(a) and sialyl-Lewis(x) with MUC-1 apomucin in a pancreatic cancer cell line
17. Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells
18. MUC1 glycoforms in breast cancer - Cell line T47D as a model for carcinoma-associated alterations of 0-glycosylation
19. A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans
20. The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer
21. Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines
22. Macrophage-tumour cell interactions: Identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin
23. Electron-microscopic studies of the CA antigen, epitectin
24. The tight junction. Morphology to molecules
25. Mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1
26. Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines
27. Establishment and characterization of a human pancreatic cancer cell line (SUIT-2) producing carcinoembryonic antigen and carbohydrate antigen 19-9
28. The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum
29. Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase
30. Chromosomes of 14 hematopoietic cell lines derived from peripheral blood of persons with and without chromosome anomalies
31. Cloning of the mouse endothelial selectins. Expression of both E- and P- selectin is inducible by tumor necrosis factor alpha
32. Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands
33. Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells
34. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells
35. L-selectin from human, but not from mouse neutrophils binds directly to E-selectin
36. Studies of the CD9 antigen defined by monoclonal antibody DU-ALL-1
37. Correlation between CA19-9 production in vitro and histological grades of differentiation in vivo in clones isolated from a human pancreatic cancer cell line (SUIT-2)
38. Differential mucin gene expression in human pancreatic and colon cancer cells
39. Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines
40. Inhibition of mucin synthesis by benzyl-alpha-GalNAc in KATO III gastric cancer and Caco-2 colon cancer cells
41. Inhibition of human HT-29 colon carcinoma cell adhesion by a 4-fluoro- glucosamine analogue
42. Two distinct classes of carbohydrate-recognition domains in animal lectins
43. P-selectin expression in a metastatic pancreatic tumor cell line (SUIT-2)
44. Selectin ligands
45. Leukocyte trafficking mediated by selectin-carbohydrate interactions
46. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
47. Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction
48. Carbohydrate recognition systems: Functional triads in cell-cell interactions
49. E-selectin binding by pancreatic tumor cells is inhibited by cancer sera
50. Secreted MUC1 mucins lacking their cytoplasmic part and carrying sialyl-Lewis a and x epitopes from a tumor cell line and sera of colon carcinoma patients can inhibit HL-60 leukocyte adhesion to E-selectin- expressing endothelial cells
51. Comparison of sialyl-Lewis a-carrying CD43 and MUC1 mucins secreted from a colon carcinoma cell line for E-selectin binding and inhibition of leukocyte adhesion
52. Expression of MUC1 mucin on activated human T cells: Implications for a role of MUC1 in normal immune regulation
53. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components
54. Expression of mucin antigens in human cancers and its relationship with malignancy potential