Characterisation of mutated proteinases derived from HIV-positive patients: Enzyme activity, vitality and inhibition

Collection of Czechoslovak Chemical Communications

Volumn 69, Issue 3, 2004, Pages 703-714

  Kožíšek, Milan ^a,b   Prejdová, Jana ^a,b   Souček, Milan ^a   Machala, Ladislav ^c   Staňková, Marie ^c   Linka, Marek ^d   Brůčková, Marie ^d   Konvalinka, Jan ^a,b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY HOSPITAL BULOVKA   (Czech Republic)

^d NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

AIDS; Antiviral drugs; Aspartic proteases; Enzyme inhibitors; Enzyme kinetics; HIV protease; Peptidomimetics; Pseudopeptides; Viral resistance

Indexed keywords

ANTIVIRUS AGENT; INDINAVIR; LOPINAVIR; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; QF 34; RITONAVIR; SAQUINAVIR; VIRUS PROTEIN;

ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; CZECH REPUBLIC; DRUG DESIGN; DRUG INHIBITION; DRUG ISOLATION; DRUG SCREENING; ENZYME ACTIVITY; GENE MUTATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MULTIDRUG RESISTANCE; PROGENY; REDUCTION; VIRUS REPLICATION;

EID: 1942518843     PISSN: 00100765     EISSN: None     Source Type: Journal    
DOI: 10.1135/cccc20040703     Document Type: Article

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