Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase

European Journal of Biochemistry

Volumn 250, Issue 2, 1997, Pages 559-566

  Konvalinka, Jan ^a   Litera, Jaroslav ^a   Weber, Jan ^a   Vondrášek, Jiří ^a   Hradílek, Martin ^a   Souček, Milan ^a   Pichová, Iva ^a   Majer, Pavel ^a   Štrop, Petr ^a   Sedláček, Juraj ^b   Heuser, Anke Mareil ^c   Kottler, Hubert ^c   Kräusslich, Hans Georg ^c,d  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

Human immunodeficiency virus 1; Inhibitor testing; Molecular modeling; Protease

Indexed keywords

PROTEINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; DIASTEREOISOMER; DRUG ACTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; PRIORITY JOURNAL;

EID: 14444288025     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.0559a.x     Document Type: Article

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