Non-active site changes elicit broad-based cross-resistance of the HIV-1 protease to inhibitors

Journal of Biological Chemistry

Volumn 274, Issue 34, 1999, Pages 23699-23701

  Olsen, David B ^a   Stahlhut, Mark W ^a   Rutkowski, Carrie A ^a   Schock, Hilary B ^a   VanOlden, Aimee L ^a   Kuo, Lawrence C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; VIRUS ENZYME;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; CROSS RESISTANCE; ENZYME ANALYSIS; ENZYME BINDING; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL;

BINDING SITES; DRUG RESISTANCE; HIV PROTEASE; HIV PROTEASE INHIBITORS; INDINAVIR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033588178     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.34.23699     Document Type: Article

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