Identification of genes involved in cell senescence and immortalization: Potential implications for tissue ageing

Novartis Foundation Symposium

Volumn 235, Issue , 2001, Pages 105-115

  Leung, James K ^a   Pereira Smith, Olivia M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORF4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AGING; ANIMAL; CELL AGING; GENETICS; HUMAN; MOLECULAR CLONING; REVIEW;

AGING; ANIMALS; CELL AGING; CLONING, MOLECULAR; HUMANS; TRANSCRIPTION FACTORS;

EID: 0035220587     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (22)

1. Bertram MJ, Bérubé NG, Hang-Swanson X, Pereira-Smith OM 1999a Assembly of a BAC contig of the complementation group B cell senescence gene candidate region at 4q33-q34.1 and identification of expressed sequences. Genomics 56:353-354
2. Bertram MJ, Bérubé NG, Hang-Swanson X et al 1999b Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol 19:1479-1485
3. Bierman EL 1978 The effect of donor age on the in vitro life span of cultured human endometrial smooth-muscle cells. In Vitro 14:951-955
4. Bunn CL, Tarrant GM 1980 Limited lifespan in somatic cell hybrids and hybrids. Exp Cell Res 127:385-396
5. Dell'Orco RT, Mertens JG, Kruse PF jr 1973 Doubling potential calendar time and senescence of human diploid cells in culture. Exp Cell Res 77:356-360
6. Dimri GP, Lee X, Basile G et al 1995 A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367
7. Goldstein S 1990 Replicative senescence: the human fibroblast comes of age. Science 249: 1129-1133
8. Harley CB, Sherwood SW 1997 Telomerase, checkpoints and cancer. Cancer Surv 29:263-284
9. Hayflick L 1965 The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636
10. Hayflick L, Moorhead PS 1961 The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621
11. Hensler PJ, Annab LA, Barrett JC, Pereira-Smith OM 1994 A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol 14:2291-2297
12. Le Guilly Y, Simon M, Lenoir P, Bourel M 1973 Long-term culture of human adult liver cells: morphological change related to in vitro senescence and effect of donors age on growth potential. Gerontologia 19:303-313
13. Martin GM, Gartler SM, Epstein CJ, Molulsky AG 1965 Diminished lifespan of cultured cells in Werner's syndrome. Fed Proc 24:678-682
14. Martin GM, Sprague CA, Epstein CJ 1970 Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest 23:86-92
15. Muggleton-Harris A, DeSimone D 1980 Replicative potential of various fusion products between W1-38 and SV40 transformed W1-38 cells and their components. Somatic Cell Genet 6:689-698
16. Ning Y, Weber JL, Killary AM, Ledbetter DH, Smith JR, Pereira-Smith OM 1991 Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Proc Natl Acad Sci USA 88:5635-5639
17. Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M 1993a Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol 13:6036-6043
18. Ogata T, Oshimura M, Namba M, Fujii M, Oishi M, Ayusawa D 1993b Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7. Jpn J Cancer Res 86:35
19. Pereira-Smith OM, Smith JR 1981 Expression of SV40 T antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts. Somatic Cell Genet 7:411-421
20. Pereira-Smith OM, Smith JR 1983 Evidence for the recessive nature of cellular immortality. Science 221:964-966
21. Pereira-Smith OM, Smith JR 1988 Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc Natl Acad Sci USA 85:6042-6046
22. Smith JR, Pereira-Smith OM 1996 Replicative senescence: implications for in vivo aging and tumor suppression. Science 273:63-67