Connexin 43 and ischemic preconditioning

Cardiovascular Research

Volumn 62, Issue 2, 2004, Pages 335-344

  Schulz, Rainer ^a   Heusch, Gerd ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Connexin; Ischemia; Preconditioning; Reperfusion

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; CASEIN KINASE; CONNEXIN 43; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHODIESTERASE III; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN ZO1; PROTON;

ACIDIFICATION; ACIDOSIS; AMINO TERMINAL SEQUENCE; APOPTOSIS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; ELECTRIC ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GAP JUNCTION; GLYCOLYSIS; HEART FUNCTION; HEART INFARCTION PREVENTION; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; ION TRANSPORT; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPERFUSION INJURY; REVIEW;

ANIMALS; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CONNEXIN 43; GAP JUNCTIONS; HUMANS; ION CHANNELS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM;

EID: 1942438678     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2003.12.017     Document Type: Review

References (143)

1. van Veen T.A.B., van Rijen H.V.M., Opthof T. Cardiac gap junction channels: modulation of expression and channel properties. Cardiovasc. Res. 51:2001;217-229.
2. Yao J.-A., Gutstein D.E., Liu F., Fishman G.I., Wit A.L. Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts. Circ. Res. 93:2003;736-743.
3. Contreras J.E., Sánchez H.A., Eugenin E.A.et al. Metabolic inhibition induces opening of unopposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc. Natl. Acad. Sci. U. S. A. 99:2002;495-500.
4. Saez J.C., Berthoud V.M., Branes M.C., Martinez A.D., Beyer E.C. Plasma membrane channels formed by connexins: their regulation and functions. Physiol. Rev. 83:2003;1359-1400.
5. De Maio A., Vega V.L. Gap junctions, homeostasis, and injury. J. Cell. Physiol. 191:2002;269-282.
6. Plotkin L.I., Bellido T. Bisphosphonate-induced, hemichannel-mediated, anti-apoptosis through the Src/ERK pathway: a gap junction-independent action of connexin43. Cell Adhes. Commun. 8:2001;377-382.
7. Quist A.P., Rhee S.K., Lin H., Lal R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J. Cell Biol. 148:2000;1063-1074.
8. Yancey S.B., John S.A., Lal R., Austin B.J., Revel J.P. The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains. J. Cell Biol. 108:1989;2241-2254.
9. Beyer E.C., Kistler J., Paul D.L., Goodenough D.A. Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J. Cell Biol. 108:1989;595-605.
10. Toyofuku T., Yabuki M., Otsu K.et al. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J. Biol. Chem. 273:1998;12725-12731.
11. Barker R.J., Price R.L., Gourdie R.G. Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions. Circ. Res. 90:2002;317-324.
12. Kardami E., Stoski R.M., Doble B.W.et al. Biochemical and ultrastructural evidence for the association of basic fibroblast growth factor with cardiac gap junctions. J. Biol. Chem. 266:1991;19551-19557.
13. Giepmans B.N., Verlaan I., Hengeveld T.et al. Gap junction protein connexin-43 interacts directly with microtubules. Curr. Biol. 11:2001;1364-1368.
14. Veenstra R.D., Wang H.-Z., Beblo D.A.et al. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ. Res. 77:1995;1156-1165.
15. Spray D.C., Burt J.M. Structure-activity relations of the cardiac gap junction channel. Am. J. Physiol., Cell Physiol. 258:1990;C195-C205.
16. Polontchouk L., Valiunas V., Haefliger J.-A., Eppenberger H.M., Weingart R. Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts. Pflügers Arch.-Eur. J. Physiol. 443:2002;676-689.
17. Takens-Kwak B.R., Jongsma H.J. Cardiac gap junctions: three distinct single channel conductances and their modulation by phosphorylating treatments. Pflügers Arch.-Eur. J. Physiol. 422:1992;198-200.
18. 2B receptor signaling. FASEB J. 17:2003;1373-1375.
19. Contreras J.E., Saez J.C., Bukauskas F.F., Bennett M.V.L. Gating and regulation of connexin 43 (Cx43) hemichannels. Proc. Natl. Acad. Sci. U. S. A. 100:2003;11388-11393.
20. VanSlyke J.K., Musil L.S. Analysis of connexin intracellular transport and assembly. Methods. 20:2000;156-164.
21. Musil L.S., Cunningham B.A., Edelman G.M., Goodenough D.A. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell-lines. J. Cell Biol. 111:1990;2077-2088.
22. Saez J.C., Nairn A.C., Czernik A.J.et al. Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. J. Mol. Cell. Cardiol. 29:1997;2131-2145.
23. Hertzberg E.L., Sáez J.C., Corpina R.A., Roy C., Kessler J.A. Use of antibodies in the analysis of connexin 43 turnover and phosphorylation. Methods. 20:2000;129-139.
24. Kwak B.R., van Veen T.A., Analbers L.J., Jongsma H.J. TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels. Exp. Cell Res. 220:1995;456-463.
25. Kwak B.R., Jongsma H.J. Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions. Mol. Cell. Biochem. 157:1996;93-99.
26. Ruiz-Meana M., Garcia-Dorado D., Lane S.et al. Persistence of gap junction communication during myocardial ischemia. Am. J. Physiol., Heart Circ. Physiol. 280:2001;H2563-H2571.
27. Lau A.F., Hatch-Pigott V., Crow D.S. Evidence that heart connexin43 is a phosphoprotein. J. Mol. Cell. Cardiol. 23:1991;659-663.
28. TenBroek E.M., Lampe P.D., Solan J.L., Reynhout J.K., Johnson R.G. Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP. J. Cell Biol. 155:2003;1307-1318.
29. Burt J.M., Spray D.C. Inotropic agents modulate gap junctional conductance between cardiac myocytes. Am. J. Physiol., Heart Circ. Physiol. 254:1988;H1206-H1210.
30. De Mello W.C. Impaired regulation of cell communication by β-adrenergic receptor activation in the failing heart. Hypertension. 27:1996;265-268.
31. Paulson A.F., Lampe P.D., Meyer R.A.et al. Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking. J. Cell Sci. 113:2000;3037-3049.
32. Lampe P.D., Qiu Q., Meyer R.A.et al. Gap junction assembly: PTX-sensitive G proteins regulate the distribution of connexin43 within cells. Am. J. Physiol., Cell Physiol. 281:2001;C1211-C1222.
33. Kojda G., Kottenberg K. Regulation of basal myocardial function by NO. Cardiovasc. Res. 41:1999;514-523.
34. Gewaltig M.T., Kojda G. Vasoprotection by nitric oxide: mechanisms and therapeutic potential. Cardiovasc. Res. 55:2002;250-260.
35. Friebe A., Koesling D. Regulation of nitric oxide-sensitive guanylyl cyclase. Circ. Res. 93:2003;96-105.
36. Ping P., Zhang J., Pierce W.M., Bolli R. Functional proteomic analysis of protein kinase C ε signaling complexes in the normal heart and during cardioprotection. Circ. Res. 88:2001;59-62.
37. Schulz R., Gres P., Skyschally A.et al. Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo. FASEB J. 17:2003;1355-1357.
38. Doble B.W., Ping P., Kardami E. The ε subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ. Res. 86:2000;293-301.
39. Bowling N., Huang X., Sandusky G.E.et al. Protein kinase C-α and -ε modulate connexin-43 phosphorylation in human heart. J. Mol. Cell. Cardiol. 33:2001;789-798.
40. Doble B.W., Ping P., Fandrich R.R., Cattani P.A., Kardami E. Protein kinase C-epsilon mediates phorbol ester-induced phosphorylation of connexin-43. Cell Adhes. Commun. 8:2001;253-256.
41. Lampe P.D., TenBreok E.M., Burt J.M.et al. Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J. Cell Biol. 149:2000;1503-1512.
42. Weng S., Lauven M., Schaefer T.et al. Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation. FASEB J. 16:2002;1114-1116.
43. Toyofuku T., Yabuki M., Kuzuya T., Tada M., Hori M. Functional role of c-Src in gap junctions of the cardiomyopathic heart. Circ. Res. 85:1999;672-681.
44. Lin R., Warn-Cramer B.J., Kurata W.E., Lau A.F. v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication. J. Cell Biol. 4:2001;815-827.
45. Lin R., Warn-Cramer B.J., Kurata W.E., Lau A.F. v-Src-mediated phosphorylation of connexin43 on tyrosine disrupts gap junctional communication in mammalian cells. Cell Adhes. Commun. 8:2001;265-269.
46. Cottrell G.T., Lin R., Warn-Cramer B.J., Lau A.F., Burt J.M. Mechanism of v-src- and mitogen-activated protein kinase-induced reduction of gap junction communication. Am. J. Physiol., Cell Physiol. 284:2003;C511-C520.
47. Doble B.W., Chen Y., Bosc D.G., Litchfield D.W., Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ. Res. 79:1996;647-658.
48. Toyofuku T., Akamatsu Y., Zhang H., Tada M., Hori M. c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. J. Biol. Chem. 276:2001;1780-1788.
49. Lidington D., Tyml K., Ouellette Y. Lipopolysaccharide-induced reductions in cellular coupling correlate with tyrosine phosphorylation of connexin 43. J. Cell. Physiol. 193:2002;373-379.
50. Polontchouk L., Ebelt B., Jackels M., Dhein S. Chronic effects of endothelin 1 and angiotensin II on gap junctions and intercellular communication in cardiac cells. FASEB J. 16:2002;87-89.
51. Brandes R.P., Popp R., Ott G.et al. The extracellular regulated kinases (ERK) 1/2 mediate cannabinoid-induced inhibition of gap junctional communication in endothelial cells. Br. J. Pharmacol. 136:2002;709-716.
52. Kim D.Y., Kam Y., Koo S.K., Joe C.O. Gating connexin 43 channels reconstituted in lipid vesicles by mitogen-activated protein kinase phosphorylation. J. Biol. Chem. 274:1999;5581-5587.
53. Warn-Cramer B.J., Cottrell G.T., Burt J.M., Lau A.F. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J. Biol. Chem. 273:1998;9188-9196.
54. Cameron S.J., Malik S., Akaibe M.et al. Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase 1/ERK 5 but not ERK1/2 kinase activation. J. Biol. Chem. 278:2003;18682-18688.
55. Petrich B.G., Gong X., Lerner D.L.et al. c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ. Res. 91:2002;640-647.
56. Barker R.J., Gourdie R.G. JNK bond regulation. Why do mammalian hearts invest in connexin43? Circ. Res. 91:2002;556-558.
57. Warn-Cramer B.J., Lampe P.D., Kurata W.E.et al. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J. Biol. Chem. 271:1996;3779-3786.
58. Lau A.F., Kurata W.E., Kanemitsu M.Y.et al. Regulation of connexin43 function by activated tyrosine protein kinases. J. Bioenerg. Biomembranes. 28:1996;359-368.
59. Cooper C.D., Lampe P.D. Casein kinase 1 regulates connexin-43 gap junction assembly. J. Biol. Chem. 277:2003;44962-44968.
60. Jeyaraman M., Tanguy S., Fandrich R.A., Lukas A., Kardami E. Ischemia-induced dephosphorylation of cardiomyocyte connexin-43 is reduced by okadaic acid and calyculin A but not fostriecin. Mol. Cell. Biochem. 242:2003;129-134.
61. Moreno A.P., Sáez J.C., Fishman G.I., Spray D.C. Human connexin43 gap junction channels. Circ. Res. 74:1994;1050-1057.
62. 1 receptors in cardiomyocytes: role for p38 MAPK. Am. J. Physiol., Heart Circ. Physiol. 285:2003;H97-H103.
63. Michel M.C., Li Y., Heusch G. Mitogen-activated protein kinases in the heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 363:2001;245-266.
64. Sayed M., Kim S.O., Salh B.S., Issinger O.-G., Pelech S.L. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase. J. Biol. Chem. 275:2000;16569-16573.
65. Cieslik K., Lee C.-M., Tang J., Wu K.K. Transcriptional regulation of endothelial nitric-oxide synthase by an interaction between casein kinase 2 and protein phosphatase 2A. J. Biol. Chem. 274:1999;34669-34675.
66. Keyse S.M. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12:2000;186-192.
67. Piper H.M. The calcium paradox revisited: an artefact of great heuristic value. Cardiovasc. Res. 45:2000;123-127.
68. Kim G.-T., Chun Y.-S., Park J.-W., Kim M.-S. Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion. Biochem. Biophys. Res. Commun. 309:2003;619-624.
69. Schulz R., Cohen M.V., Behrends M., Downey J.M., Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc. Res. 52:2001;181-198.
70. i in rabbit ventricular myocytes during metabolic inhibition. J. Mol. Cell. Cardiol. 33:2001;2145-2155.
71. John S.A., Kondo R., Wang S.-Y., Goldhaber J.I., Weiss J.N. Connexin-43 hemichannels opened by metabolic inhibition. J. Biol. Chem. 274:1999;236-240.
72. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1986;1124-1136.
73. Piot C.A., Padmanaban D., Ursell P.C., Sievers R.E., Wolfe C.L. Ischemic preconditioning decreases apoptosis in rat hearts in vivo. Circulation. 96:1997;1598-1604.
74. Maulik N., Yoshida T., Engelman R.M.et al. Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion. Mol. Cell. Biochem. 186:1998;139-145.
75. Nakamura M., Wang N.-P., Zhao Z.-Q.et al. Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart. Cardiovasc. Res. 45:2000;661-670.
76. Sakamoto J., Miura T., Tsuchida A.et al. Reperfusion arrhythmias in the murine heart: their characteristics and alteration after ischemic preconditioning. Basic Res. Cardiol. 94:1999;489-495.
77. Shiki K., Hearse D.J. Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias. Am. J. Physiol., Heart Circ. Physiol. 253:1987;H1470-H1476.
78. Hagar J.M., Hale S.L., Kloner R.A. Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ. Res. 68:1991;61-68.
79. Wang G.-Y., Wu S., Pei J.-M., Yu X.C., Wong T.-M. κ-but not δ-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats. Am. J. Physiol., Heart Circ. Physiol. 280:2001;H384-H391.
80. Cohen M.V., Yang X.-M., Downey J.M. Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning. Circ. Res. 74:1994;998-1004.
81. Kaszala K., Vegh A., Papp J.G., Parratt J.R. Time course of the protection against ischaemia and reperfusion-induced ventricular arrhythmias resulting from brief periods of cardiac pacing. J. Mol. Cell. Cardiol. 28:1996;2085-2095.
82. Ovize M., Aupetit J.-F., Rioufol G.et al. Preconditioning reduces infarct size but accelerates time to ventricular fibrillation in ischemic pig heart. Am. J. Physiol., Heart Circ. Physiol. 269:1995;H72-H79.
83. Shattock M.J., Lawson C.S., Hearse D.J., Downey J.M. Electrophysiogical characteristics of repetitive ischemic preconditioning in the pig heart. J. Mol. Cell. Cardiol. 28:1996;1339-1347.
84. ATP channels. Am. J. Physiol., Heart Circ. Physiol. 42:1997;H2804-H2810.
85. Grund F., Sommerschild H.T., Kirkeboen K.A., Ilebekk A. Proarrhythmic effects of ischemic preconditioning in anesthetized pigs. Basic Res. Cardiol. 92:1997;417-425.
86. 2+-activated force by inorganic phosphate. Circ. Res. 59:1986;270-282.
87. Jacobus W.E., Pores I.H., Lucas S.K., Kallman C.H., Weisfeldt M.L., Flaherty J.T. The Role of Intracellular pH in the Control of Normal and Ischemic Myocardial Contractility: A 31P Nuclear Magnetic Resonance and Mass Spectrometry Study. 1982;537-565 Alan R. Liss, New York.
88. Guth B.D., Martin J.F., Heusch G., Ross J. Jr. Regional myocardial blood flow, function and metabolism using phosphorus-31 nuclear magnetic resonance spectroscopy during ischemia and reperfusion. J. Am. Coll. Cardiol. 10:1987;673-681.
89. Weinbrenner C., Baines C.P., Liu G.-C.et al. Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia. Circulation. 98:1998;899-905.
90. Kim S.O., Baines C.P., Critz S.D.et al. Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart. Biochem. Cell Biol. 77:1999;559-567.
91. Lochner A., Genade S., Tromp E., Podzuweit T., Moolman J.A. Ischemic preconditioning and the β-adrenergic signal transduction pathway. Circulation. 100:1999;958-966.
92. Albert C.J., Ford D.A. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Am. J. Physiol., Heart Circ. Physiol. 276:1999;H642-H650.
93. Simonis G., Weinbrenner C., Strasser R.H. Ischemic preconditioning promotes a transient, but not sustained translocation of protein kinase C and sensitization of adenyl cyclase. Basic Res. Cardiol. 98:2003;104-118.
94. Takeishi Y., Huang Q., Wang T.et al. Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning. J. Mol. Cell. Cardiol. 33:2001;1989-2005.
95. Steenbergen C., Perlman M.E., London R.E., Murphy E. Mechanism of preconditioning. Ionic alterations. Circ. Res. 72:1993;112-125.
96. Smith G.B., Stefenelli T., Wu S.T.et al. Rapid adaptation of myocardial calcium homeostasis to short episodes of ischemia in isolated rat hearts. Am. Heart j. 131:1996;1106-1112.
97. Ylitalo K.V., Ala-Rami A., Liimatta E.V., Peuhkurine K.J., Hassinen I.E. Intracellular free calcium and mitochondrial membrane potential in ischemia/reperfusion and preconditioning. J. Mol. Cell. Cardiol. 32:2000;1223-1238.
98. ATP channels. Am. J. Physiol., Heart Circ. Physiol. 280:2001;H2321-H2328.
99. Beardslee M.A., Lerner D.L., Tadros P.N.et al. Dephosphorylation and intracellular redistributoin of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ. Res. 87:2000;656-662.
100. Jain S.K., Schuessler R.B., Saffitz J.E. Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning. Circ. Res. 92:2003;1138-1144.
101. Miura T., Ohnuma Y., Kuno A., Tanno M., Ichikawa Y., Nakamura Y.et al. Protective role of gap junctions in preconditioning against myocardial infarction. Am. J. Physiol., Heart Circ. Physiol. 286:2004;H214-H221.
102. Garcia-Dorado D., Ruiz-Meana M., Padilla F., Rodriguez-Sinovas A., Mirabet M. Gap-junction-mediated intercellular communication in ischemic preconditioning. Cardiovasc. Res. 55:2002;456-465.
103. Kondo R.P., Wang S.Y., John S.A., Weiss J.N., Goldhaber J.I. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J. Mol. Cell. Cardiol. 32:2000;1859-1872.
104. + and cellular energy. Circ. Res. 77:1995;349-406.
105. 23Na NMR demonstrates prolonged increase of intracellular sodium following transient regional ischemia in the in situ pig heart. Basic Res. Cardiol. 94:1999;60-69.
106. 23Na NMR Study. J. Mol. Cell. Cardiol. 23:1991;297-307.
107. + through gap junctions. Circ. Res. 85:1999;280-287.
108. Garcia-Dorado D., Inserte J., Ruiz-Meana M.et al. Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation. 96:1997;3579-3586.
109. Duthe F., DuPont E., Verrechia F.et al. Dephosphorylation agents depress gap junctional communication between rat cardiac cells without modifying the connexin43 phosphorylation degree. Gen. Physiol. Biophys. 19:2000;441-449.
110. Garcia-Dorado D., Théroux P., Duran J.M.et al. Selective inhibition of the contractile apparatus. A new approach to modification of infarct size, infarct composition, and infarct geometry during coronary artery occlusion and reperfusion. Circulation. 85:1992;1160-1174.
111. + extrusion in preconditioned rat heart. Am. J. Physiol., Heart Circ. Physiol. 273:1997;H2257-H2262.
112. Armstrong S.C., Shivell C., Ganote C.E. Sarcolemmal blebs and osmotic fragility as correlates of irreversible ischemic injury in preconditioned isolated rabbit cardiomycytes. J. Mol. Cell. Cardiol. 33:2001;149-160.
113. Jiang Z.-S., Padua R.R., Ju H.et al. Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C. Am. J. Physiol., Heart Circ. Physiol. 282:2002;H1071-H1080.
114. Htun P., Ito W.D., Hoefer I.E., Schaper J., Schaper W. Intramyocardial infusion of FGF-1 mimics ischemic preconditioning in pig myocardium. J. Mol. Cell. Cardiol. 30:1998;867-877.
115. Detillieux K.A., Sheikh F., Kardami E., Cattini P.A. Biological activities of fibroblast growth factor-2 in the adult myocardium. Cardiovasc. Res. 57:2003;8-19.
116. Azzam E.I., de Toledo S.M., Little J.B. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. U. S. A. 98:2001;473-478.
117. Li G., Whittaker P., Yao M., Kloner R.A., Przyklenk K. The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts. Cardiovasc. Pathol. 11:2002;158-165.
118. Schwanke U., Konietzka I., Duschin A.et al. No ischemic preconditioning in heterozygous connexin43-deficient mice. Am. J. Physiol., Heart Circ. Physiol. 283:2002;H1740-H1742.
119. Schwanke U., Li X., Schulz R., Heusch G. No ischemic preconditioning in heterozygous connexin 43-deficient mice: a further in vivo study. Basic Res. Cardiol. 98:2003;181-182.
120. Padilla F., Garcia-Dorado D., Rodriguez-Sinovas A.et al. Protection afforded by ischemic preconditioning is not mediated by effects on cell-to-cell electrical coupling during myocardial ischemia-reperfusion. Am. J. Physiol., Heart Circ. Physiol. 285:2003;H1909-H1916.
121. Li X., Heinzel F.R., Boengler K., Schulz R., Heusch G. No ischemic preconditioning of isolated cardiomyocytes from connexin 43-deficient mice. J. Mol. Cell. Cardiol. 2004;. [in press].
122. Li H., Brodsky S., Kumari S.et al. Paradoxical overexpression and translocation of connexin 43 in homocysteine-treated endothelial cells. Am. J. Physiol., Heart Circ. Physiol. 282:2001;H2124-H2133.
123. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 6:2000;513-519.
124. Krieg T., Cohen M.V., Downey J.M. Mitochondria and their role in preconditioning's trigger phase. Basic Res. Cardiol. 98:2003;228-234.
125. Taimor G. Mitochondria as common endpoints in early and late preconditioning. Cardiovasc. Res. 59:2003;266-267.
126. Dang X., Doble B.W., Kardami E. The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth. Mol. Cell. Biochem. 242:2003;35-38.
127. Bolli R. The late phase of preconditioning. Circ. Res. 87:2000;972-983.
128. Kanno S., Kovacs A., Yamada K., Saffitz J. Connexin 43 as a determinant of myocardial infarct size following coronary occlusion in mice. J. Am. Coll. Cardiol. 41:2003;681-686.
129. Spray D.C., White R.L., Mazet F., Bennett M.V. Regulation of gap junctional conductance. Am. J. Physiol. 248:1985;H753-H764.
130. Noma A., Tsuboi N. Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea-pig. J. Physiol. 382:1987;193-211.
131. ++. J. Gen. Physiol. 95:1990;1061-1075.
132. (2+)-calmodulin mediated modulation of the electrical coupling of ventricular myocytes isolated from guinea pig heart. J. Mol. Cell. Cardiol. 26:1994;1007-1015.
133. Firek L., Weingart R. Modification of gap junction conductance by divalent cations and protons in neonatal rat heart cells. J. Mol. Cell. Cardiol. 27:1995;1633-1643.
134. Zaniboni M., Rossini A., Swietach P.et al. Proton permeation through the myocardial gap junction. Circ. Res. 93:2003;726-735.
135. Sugiura H., Toyama J., Tsuboi N., Kamiya K., Kodama I. ATP directly affects junctional conductance between paired ventricular myocytes isolated from guinea pig heart. Circ. Res. 66:1990;1095-1102.
136. Duthe F., Plaisance I., Sarrouilhe D., Hervé J.-C. Endogenous protein phosphatase 1 runs down gap junctional communication of rat ventricular myocytes. Am. J. Physiol., Cell Physiol. 281:2001;C1648-C1656.
137. Munster P.N., Weingart R. Effects of phorbol ester on gap junctions of neonatal rat heart cells. Pflügers Arch.-Eur. J. Physiol. 423:1993;181-188.
138. Bastide B., Jarry-Guichard T., Briand J.P., Délèze J., Gros D. Effect of antipeptide antibodies directed against three domains of connexin43 on the gap junctional permeability of cultured cells. J. Membr. Biol. 150:1996;243-253.
139. Hermans M.M., Kortekaas P., Jongsma H.J., Rook M.B. pH sensitivity of cardiac gap junction proteins, connexin 45 and 43. Pflügers Arch.-Eur. J. Physiol. 731:1995;138-140.
140. Ek-Vitorin J.F., Calero G., Morley G.E.et al. pH regulation of connexin43: molecular analysis of the gating particle. Biophys. J. 71:1996;1273-1284.
141. Cruciani V., Husoy T., Mikalsen S.O. Pharmacological evidence for system-dependent involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication. Exp. Cell Res. 268:2001;150-161.
142. Ruch R.J., Trosko J.E., Madhukar B.V. Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation. J. Cell. Biochem. 83:2001;163-169.
143. Postma F.R., Hengeveld T., Alblas J.et al. Acute loss of cell-cell communication caused by G protein-coupled receptors: A critical role for c-Src. J. Cell Biol. 140:1998;1199-1209.