Cyclic AMP and LDL trigger a rapid enchancement in gap junction assembly through a stimulation of connexin trafficking

Journal of Cell Science

Volumn 113, Issue 17, 2000, Pages 3037-3049

  Paulson, A F ^a   Lampe, P D ^a   Meyer, R A ^a   TenBroek, E ^a   Atkinson, M M ^a   Walseth, T F ^a   Johnson, R G ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

CAMP; Connexin43; Gap junction; Junction assembly; Trafficking

Indexed keywords

8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; BREFELDIN A; CONNEXIN 43; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GAP JUNCTION PROTEIN; ISOBUTYLMETHYLXANTHINE; LOW DENSITY LIPOPROTEIN; MONENSIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NOCODAZOLE; PROTEIN KINASE INHIBITOR; REAGENT;

ANIMAL CELL; ARTICLE; CELL AGGREGATION; CELL COMMUNICATION; CELL CONTACT; CELL LABELING; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FREEZE FRACTURE; GAP JUNCTION; HEPATOMA CELL; IMMUNOBLOTTING; INTRACELLULAR MEMBRANE; MEMBRANE TRANSPORT; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; STAINING; STIMULATION; STRUCTURE ANALYSIS;

ANIMALIA;

EID: 0033828666     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.113.17.3037     Document Type: Article

References (66)

1. Cyclic AMP modifies the cellular distribution of connexin43 and induces a persistent increase in the junctional permeability of mouse mammary tumor
2. Cell junction and cycle AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type
3. Rapid turnover of connexin43 in the adult rat heart
4. 2+
5. Cyclic AMP modulates the rate of constituitive exocytosis of apical membrane proteins in Madin-Darby canine kidney cells
6. Cyclic AMP induces rapid increases in gap junction permeability and changes in the cellular distribution of Connexin 43
7. Ionotropic agents modulate gap junctional conductance between cardiac myocytes
8. cAMP promotes gap junctional coupling in T84 cells
9. Brefeldin A: The advantage of being uncompetitive
10. Evidence for physiological regulation of myometrial gap junction permeability
11. Phosphorylation of connexin 43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts
12. Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes
13. Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos
14. Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini
15. Golgi-disturbing agents
16. Sendaiviral HN and F glycoproteins as probes of plasma-membrane protein catabolism in HTC cells. Studies with fusogenic reconstituted Sendai-viral envelopes
17. Studies on gap junction formation and regulation in myometrium
18. Intracellular trafficking pathways in the assembly of connexins into gap junctions
19. Phosphorylation and expression of connexin-43 ovarian gap junction protein are regulated by luteinizing hormone
20. Dopaminergic modulation of gap junction permeability between amacrine cells in mammalian retina
21. Gsα stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase
22. Mechanisms of plasma membrane protein degradation: Recycling proteins are degraded more rapidly than those confined to the cell surface
23. Myometrial connexin 43 trafficking and gap junction assembly at term and in preterm labor
24. Dynamics of gap junctions observed in living cells with connexin43-GFP chimeric protein
25. Gap junction formation between reaggregated Novikoff hepatoma cells
26. Gap junction formation: A self-assembly model involving membrane domains of lipid and protein
27. Gap junction assembly: The external domains in the connexins fulfill an essential function
28. Brefeldin A: Insights into the control of membrane traffic and organelle structure
29. Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells
30. Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions
31. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
32. Degradation of connexin43 gap junctions involves both the proteasome and the lysosome
33. Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes
34. Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells
35. Analyzing phorbol ester effects on gap junction communication: A dramatic inhibition of assembly
36. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells
37. Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanism
38. Upregulation of gap junctional intercellular communication in immortalized gonadotropin-releasing hormone neurons by stimulation of the cyclic AMP pathway
39. Transcription of the gene for the gap junctional protein connexin43 and expression of functional cell-to-cell channels are regulated by cAMP
40. Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP
41. Increased gap junction assembly between cultured cells upon cholesterol supplementation
42. Enhanced gap junction formation with LDL and apolipoprotein B
43. Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies
44. Expression of the gap junction protein connexin 43 in embryonic chick lens: Molecular cloning, ultrastructural localization and post-translational phosphorylation
45. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines
46. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques
47. Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER
48. Ultrastructural analysis of gap junction in C6 glioma cells transfected with connexin43 cDNA
49. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate
50. Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL
51. Biophysical properties of gap junctions between freshly dispersed pairs of mouse pancreatic beta cells
52. Gap junctions between Novikoff hepatoma cells following dissociation and recovery in the absence of cell contact
53. Analysis of gap junctions and formation plaques between reaggregating Novikoff hepatoma cells
54. Trapping an intermediate form of connexin43 in the Golgi
55. cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide
56. Intracellular cyclic AMP concentration modulates gap junction permeability in parturient rat myometrium
57. Hormonal regulation of intercellular communication: Parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells
58. Characterization of gap junctions between cultured leptomeningeal cells
59. Perturbation of vesicular traffic with the carboxylic ionophore monensin
60. Enhanced gap junction assembly following the elevation of cAMP requires full length Cx43
61. Cyclic adenosine monophosphate stimulates biosynthesis and phosphorylation of the 26 kDa gap junction protein in cultured mouse hepatocytes
62. A heterotrimeric G protein of the G(i) family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells
63. Identification of Connexin43 as a functional target for Wnt signalling
64. Genetic diseases and gene knockouts reveal diverse connexin functions
65. The 43-kD polypeptide of heart gap junctions: Immunolocalization (I), topology (II), and functional domains (III)