Expression of CYP4F12 in Gastrointestinal and Urogenital Epithelia

Basic and Clinical Pharmacology and Toxicology

Volumn 94, Issue 4, 2004, Pages 177-183

  Stark, Katarina ^a   Schauer, Lydia ^a   Sahlén, Göran E ^b   Ronquist, Gunnar ^b   Oliw, Ernst H ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 4F12; PEPTIDE ANTIBODY; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE EPITHELIUM; MALE; MOLECULAR SIZE; PRIORITY JOURNAL; PROSTATE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEMINAL VESICLE; STOMACH EPITHELIUM; TISSUE DISTRIBUTION; UROGENITAL SYSTEM;

ALIA;

EID: 1942437980     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2004.pto940404.x     Document Type: Conference Paper

References (36)

1. Bradford, M. M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
2. Bylund, J., N. Finnström & E. H. Oliw: Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. Biochem. Biophys. Res. Commun. 1999, 261, 169-174.
3. Bylund, J., M. Hidestrand, M. Ingelman-Sundberg & E. H. Oliw: Identification of CYP4F8 in human seminal vesicles as a prominent 19- hydroxylase of prostaglandin endoperoxides. J. Biol. Chem. 2000, 275, 21844-21849.
4. Bylund, J., M. Bylund & E. H. Oliw: cDNA cloning and expression of CYP4F12, a novel human cytochrome P450. Biochem. Biophys. Res. Commun. 2001, 280, 892-897.
5. Bylund, J., A. G. Harder, K. G. Maier, R. J. Roman & D. R. Harder: Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. Arch. Biochem. Biophys. 2003, 412, 34-41.
6. Bylund, J., C. Zhang & D. R. Harder: Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Biochem. Biophys. Res. Commun. 2002, 296, 677-684.
7. Carlsson, L., O. Nilsson, A. Larsson, M. Stridsberg, G. Sahlén & G. Ronquist: Characteristics of human prostasomes isolated from three different sources. Prostate 2003, 54, 322-330.
8. Chang, Y. T. & G. H. Loew: Homology modeling and substrate binding study of human CYP4A11 enzyme. Proteins 1999, 34, 403-415.
9. Christmas, P., J. P. Jones, C. J. Patten, D. A. Rock, Y. Zheng, S. M. Cheng, B. M. Weber, N. Carlesso, D. T. Scadden, A. E. Rettie & R. J. Soberman: Alternative splicing determines the function of CYP4F3 by switching substrate specificity. J. Biol. Chem. 2001, 276, 38166-38172.
10. Edwards, R. J., D. A. Adams, P. S. Watts, D. S. Davies & A. R. Boobis: Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. Biochem. Pharmacol. 1998, 56, 377-387.
11. Finnström, N., C. Bjelfman, T. G. Söderström, G. Smith, L. Egevad, B. J. Norlen, C. R. Wolf & A. Rane: Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR. Eur. J. Clin. Invest. 2001, 31, 880-886.
12. Funk, C. D.: Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001, 294, 1871-1875.
13. Hakkola, J., M. Pasanen, J. Hukkanen, O. Pelkonen, J. Maenpaa, R. J. Edwards, A. R. Boobis & H. Raunio: Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem. Pharmacol. 1996, 51, 403-411.
14. Hashizume, T., S. Imaoka, T. Hiroi, Y. Terauchi, T. Fujii, H. Miyazaki, T. Kamataki & Y. Funae: cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Biochem. Biophys. Res. Commun. 2001, 280, 1135-1141.
15. Hashizume, T., S. Imaoka, M. Mise, Y. Terauchi, T. Fujii, H. Miyazaki, T. Kamataki & Y. Funae: Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. J. Pharmacol. Exp. Therap. 2002, 300, 298-304.
16. Helvig, C., J. Wisniewski, M. Gao, M. Amad, H. Ramshaw & B. Korczak: Biochemical characterization of CYP4F11, a novel human cytochrome P450. Cytochromes P450, Biochemistry, Biophysics and Drug Metabolism. Prague, 2003, pp. 171-176.
17. Ingelman-Sundberg, M.: Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes. Mutat. Res. 2001, 482, 11-19.
18. Ingelman-Sundberg, M.: Polymorphism of cytochrome P450 and xenobiotic toxicity. Toxicology 2002, 181-182, 447-452.
19. Jakobsson, P. J., S. Thorén, R. Morgenstern & B. Samuelsson: Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U S A 1999, 96, 7220-7225.
20. Kalsotra, A., S. Anakk, C. L. Boehme & H. W. Strobel: Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats. Drug. Metab. Dispos. 2002, 30, 1022-1028.
21. Kelly, R. W.: Immunomodulators in human seminal plasma: a vital protection for spermatozoa in the presence of infection? Int. J. Androl. 1999, 22, 2-12.
22. Kikuta, Y., E. Kusunose & M. Kusunose: Prostaglandin and leukotriene omega-hydroxylases. Prostaglandins Other Lipid Mediat. 2002, 68-69, 345-362.
23. Lasker, J. M., W. B. Chen, I. Wolf, B. P. Bloswick, P. D. Wilson & P. K. Powell: Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. J. Biol. Chem. 2000, 275, 4118-4126.
24. Leighton, J.K., S. Canning, H.D. Guthrie, & J.M. Hammond: Expression of cytochrome P450 1A1, an estrogen hydroxylase, in ovarian granulosa cells is developmentally regulated. J. Steroid Biochem. Molec. Biol. 1995, 52, 351-356.
25. Lundell, K.: Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]. Biochem. J. 2002, 363, 297-303.
26. Nebert, D. W. & D. W. Russell: Clinical importance of the cytochromes P450. Lancet 2002, 360, 1155-1162.
27. 1, in the ram. Acta Physiol. Scand. 1986, 127, 45-49.
28. Oliw, E. H.: Biosynthesis of 18(RD)-hydroxyeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles. Some properties of a novel fatty acid omega 3-hydroxylase and omega 3-epoxygenase. J. Biol. Chem. 1989, 264, 17845-17853.
29. Popa, C., A. J. Dicker, A. L. Dahler & N. A. Saunders: Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible. Brit. J. Dermatol. 1999, 141, 460-468.
30. Roman, R. J.: P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol. Rev. 2002, 82, 131-185.
31. Schuessler, M., N. Astecker, G. Herzig, G. Vorisek & I. Schuster: Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D(3): CYP27 in epidermis completes the set of essential vitamin D(3)-hydroxylases. Steroids 2001, 66, 399-408.
32. Simpson, A. E.: The cytochrome P450 4 (CYP4) family. Gen. Pharmacol. 1997, 28, 351-359.
33. Stark, K., H. Törmä, M. Cristea & E. H. Oliw: Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. Arch. Biochem. Biophys. 2003, 409, 188-196.
34. Tanabe, T. & V. Ullrich: Prostacyclin and thromboxane synthases. J. Lipid Mediat. Cell Signal. 1995, 12, 243-255.
35. Utleg, A. G., E. C. Yi, T. Xie, P. Shannon, J. T. White, D. R. Goodlett, L. Hood & B. Lin: Proteomic analysis of human prostasomes. Prostate 2003, 56, 150-161.
36. Zheng, Y. M., B. R. Baer, M. B. Kneller, K. R. Henne, K. L. Kunze & A. E. Rettie: Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate. Biochemistry 2003, 42, 4601-4606.