Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]

Biochemical Journal

Volumn 363, Issue 2, 2002, Pages 297-303

  Lundell, Kerstin ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

hydroxylation; CYP4A subfamily; Yeast cell expression

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; ENZYMES; FATTY ACIDS; YEAST;

REGIOSELECTIVITY;

CLONING;

CYTOCHROME P450 4A24; CYTOCHROME P450 4A25; CYTOCHROME P450 ISOENZYME; KIDNEY ENZYME; LAURIC ACID; LIVER ENZYME; OXYGENASE; PALMITIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE EXPRESSION; KIDNEY; LIVER; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN MOTIF; RESTRICTION MAPPING; SWINE; YEAST CELL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; GENE EXPRESSION; KIDNEY; LAURIC ACIDS; LIVER; MALE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; PALMITIC ACID; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; SWINE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0037090466     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630297     Document Type: Article

References (25)

1. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
2. Validation of the (ω-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1
3. Different mechanisms of regioselection of fatty acid hydroxylation by laurate (ω-1)-hydroxylating P450s, P450 2C2 and P450 2E1
4. The cytochrome P450 4 (CYP4) family
5. LAω). Identification of a new cytochrome P-450 gene family
6. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation
7. The role of the cytochrome P450-dependent metabolites of arachidonic acid in blood pressure regulation and renal function: A review
8. Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21)
9. 1 and lauric acid by pig kidney microsomes and a purified kidney cytochrome P-450
10. Characterisation of taurochenodeoxycholic acid 6α-hydroxylase from pig liver microsomes
11. Genomic sequencing
12. 5
13. Improved method for high efficiency transformation of intact yeast cells
14. Yeast expression of animal and plant P450s in optimized redox environments
15. Protein measurement with the folin phenol reagent
16. 4
17. ω- and (ω-1)-hydroxylation of eicosanoids and fatty acids by high-performance liquid chromatography
18. Combining evolutionary information and neural networks to predict protein secondary structure
19. Homology modeling and substrate binding study of human CYP4A11 enzyme
20. Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: Identification of cytochrome P-450 gene subfamily IVB
21. How similar are P450s and what can their differences teach us?
22. Mammalian microsomal cytochrome P450 monooxygenase: Structural adaptations for membrane binding and functional diversity
23. Molecular basis for the ω-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases
24. The P450 superfamily: Update on new sequences, gene mapping, and recommended nomenclature
25. Molecular evolution of P450 superfamily and P450-containing monooxygenase systems