Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate

Biochemistry

Volumn 42, Issue 15, 2003, Pages 4601-4606

  Zheng, Yi Min ^a   Baer, Brian R ^a   Kneller, M Byron ^a   Henne, Kirk R ^a   Kunze, Kent L ^a   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT HEME BINDING;

CATALYSIS; CELLS; ESTERS; PORPHYRINS;

BIOCHEMISTRY;

ACID; ALANINE; ASPARTIC ACID; CYTOCHROME P450 4B1; CYTOCHROME P450 ISOENZYME; DIMER; GLUTAMIC ACID; GLYCINE; HEME; LAURIC ACID; MONOMER; PORPHYRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CATALYSIS; COVALENT BOND; DISSOCIATION; ENZYME ACTIVE SITE; HYDROXYLATION; INSECT CELL; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN METABOLISM; RABBIT; STEREOCHEMISTRY; WILD TYPE;

ARYL HYDROCARBON HYDROXYLASES; DIMERIZATION; GLUTAMIC ACID; HEME; LAURIC ACIDS; MUTATION; OXYGEN; PORPHYRINS;

ANIMALIA; INSECTA; ORYCTOLAGUS CUNICULUS;

EID: 0037461344     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020667t     Document Type: Article

References (26)

1. Guengerich, F. P. (2001) Chem. Res. Toxicol. 14, 611-50.
2. Sono, M., Roach, M. P., Coulter, E. D., and Dawson, J. H. (1996) Chem. Rev. 96, 2841-87.
3. Henne, K. R., Kunze, K. L., Zheng, Y.-M., Christmas, P., Soberman, R. J., and Rettie, A. E. (2001) Biochemistry 40, 12925-31.
4. Hoch, U., and Ortiz De Montellano, P. R. (2001). J. Biol. Chem. 276, 11339-46.
5. LeBrun, L. A., Xu, F., Kroetz, D. L., and Ortiz de Montellano, P. R. (2002) Biochemistry 41, 5931-7.
6. LeBrun, L. A., Hoch, U., and Ortiz de Montellano, P. R. (2002) J. Biol. Chem. 277, 12755-61.
7. Rae, T. D., and Goff, H. M. (1998) J. Biol. Chem. 273, 27968-77.
8. Oxvig, C., Thomsen, A. R., Overgaard, M. T., Sorensen, E. S., Hojrup, P., Bjerrum, M. J., Gleich, G. J., and Sottrup-Jensen, L. (1999) J. Biol. Chem. 274, 16953-8.
9. Fiedler, T. J., Davey, C. A., and Fenna, R. E. (2000). J. Biol. Chem. 275, 11964-71.
10. Barker, P. D., and Ferguson, S. J. (1999) Structure Fold Des. 7, R281-90.
11. Taniuchi, H., Basile, G., Taniuchi, M., and Veloso, D. (1983) J. Biol. Chem. 258, 10963-6.
12. DePillis, G. D., Ozaki, S., Kuo, J. M., Maltby, D. A., and Ortiz de Montellano, P. R. (1997) J. Biol. Chem. 272, 8857-60.
13. Rettie, A. E., Sheffels, P. R., Korzekwa, K. R., Gonzalez, F. J., Philpot, R. M., and Baillie, T. A. (1995) Biochemistry 34, 7889-95.
14. Czerwinski, M., McLemore, T. L., Philpot, R. M., Nhamburo, P. T., Korzekwa, K., Gelboin, H. V., and Gonzalez, F. J. (1991) Cancer Res. 51, 4636-8.
15. Thornton-Manning, J., Appleton, M. L., Gonzalez, F. J., and Yost, G. S. (1996) J. Pharmacol. Exp. Ther. 276, 21-9.
16. Gotoh, O. (1992) J. Biol. Chem. 267, 83-90.
17. Guan, X., Fisher, M. B., Lang, D. H., Zheng, Y. M., Koop, D. R., and Rettie, A. E. (1998) Chem. Biol. Interact. 110, 103-21.
18. Dickmann, L. J., Rettie, A. E., Kneller, M. B., Kim, R. B., Wood, A. J., Stein, C. M., Wilkinson, G. R., and Schwarz, U. I. (2001) Mol. Pharmacol. 60, 382-7.
19. Henne, K. R., Fisher, M. B., Iyer, K. R., Lang, D. H., Trager, W. F., and Rettie, A. E. (2001) Biochemistry 40, 8597-605.
20. Fenna, R., Zeng, J., and Davey, C. (1995) Arch. Biochem. Biophys. 316, 653-6.
21. Fayadat, L., Niccoli-Sire, P., Lanet, J., and Franc, J. L. (1999) J. Biol. Chem. 274, 10533-8.
22. Lardinois, O. M., Medzihradszky, K. F., and Ortiz de Montellano, P. R. (1999) J. Biol. Chem. 274, 35441-8.
23. Witting, P. K., Douglas, D. J., and Mauk, A. G. (2000) J. Biol. Chem. 275, 20391-8.
24. Lardinois, O. M., and de Montellano, P. R. (2001) J. Biol. Chem. 276, 23186-91.
25. Colas, C., Kuo, J. M., and Ortiz de Montellano, P. R. (2002) J. Biol. Chem. 277, 7191-200.
26. Ator, M. A., and Ortiz de Montellano, P. R. (1987) J. Biol. Chem. 262, 1542-51.