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Archives of Biochemistry and Biophysics

Volumn 391, Issue 1, 2001, Pages 49-55

Covalent alteration of the CYP3A4 active site: Evidence for multiple substrate binding domains

(2) Schrag, Michael L a,b Wienkers, Larry C a

a PFIZER INC (United States)

b MERCK RESEARCH LABORATORIES (United States)

Author keywords

CYP3A4; Mechanism based inactivation; Midazolam; Substrate dependent; Testosterone; Triazolam

Indexed keywords

CYTOCHROME P450 3A4; OXYGENASE; TESTOSTERONE; TRIAZOLAM;

ARTICLE; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MATHEMATICAL ANALYSIS; MICHAELIS MENTEN KINETICS; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 27244462157 PISSN: 00039861 EISSN: None Source Type: Journal
DOI: 10.1006/abbi.2001.2401 Document Type: Article

Times cited : (77)

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