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Volumn 24, Issue 4, 1996, Pages 414-421

Warfarin-Fluconazole I - Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: In vitro studies

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DRUG METABOLITE; ENZYME INHIBITOR; FLUCONAZOLE; FURAFYLLINE; WARFARIN;

EID: 0029877219     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (175)

References (35)
  • 1
    • 0025363182 scopus 로고
    • Fluconazole: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in superficial and systemic mycoses
    • S. M. Grant and S. P. Clissold: Fluconazole: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in superficial and systemic mycoses. Drugs 39, 877-914 (1990).
    • (1990) Drugs , vol.39 , pp. 877-914
    • Grant, S.M.1    Clissold, S.P.2
  • 2
    • 0025265898 scopus 로고
    • Interaction of azole antifungal antibiotics with cytochrome P450-dependent 14α-sterol demethylase purified from Candida albicans
    • C. A. Hitchcock, K. Dickinson, S. B. Brown, E. G. Evans, and D. J. Adams: Interaction of azole antifungal antibiotics with cytochrome P450-dependent 14α-sterol demethylase purified from Candida albicans. Biochem. J. 266, 475-480 (1990).
    • (1990) Biochem. J. , vol.266 , pp. 475-480
    • Hitchcock, C.A.1    Dickinson, K.2    Brown, S.B.3    Evans, E.G.4    Adams, D.J.5
  • 3
    • 0027439883 scopus 로고
    • Low-dose fluconazole therapy potentiates the hypoprothrombinemic response of warfarin sodium
    • L. L. Crussell-Porter, J. P. Rindone, M. A. Ford, and D. W. Jaskar: Low-dose fluconazole therapy potentiates the hypoprothrombinemic response of warfarin sodium. Arch. Intern. Med. 153, 102-104 (1993).
    • (1993) Arch. Intern. Med. , vol.153 , pp. 102-104
    • Crussell-Porter, L.L.1    Rindone, J.P.2    Ford, M.A.3    Jaskar, D.W.4
  • 4
    • 0025219525 scopus 로고
    • Drug interactions with fluconazole
    • J. D. Lazar and K. D. Wilner: Drug interactions with fluconazole. Rev. Infect. Dis.12, S327-S333 (1990).
    • (1990) Rev. Infect. Dis. , vol.12
    • Lazar, J.D.1    Wilner, K.D.2
  • 5
    • 0027440142 scopus 로고
    • Pharmacokinetic drug interactions with antimicrobial agents
    • J. G. Gillum, D. S. Israel, and R. E. Polk: Pharmacokinetic drug interactions with antimicrobial agents. Pharmacokinet. Drug Interact. 25, 450-482 (1993).
    • (1993) Pharmacokinet. Drug Interact. , vol.25 , pp. 450-482
    • Gillum, J.G.1    Israel, D.S.2    Polk, R.E.3
  • 6
    • 0026802087 scopus 로고
    • Drug interactions with warfarin
    • N. A. Buckley and A. H. Dawson: Drug interactions with warfarin. Med. J. Aust. 157, 479-483 (1992).
    • (1992) Med. J. Aust. , vol.157 , pp. 479-483
    • Buckley, N.A.1    Dawson, A.H.2
  • 7
    • 0025674613 scopus 로고
    • Possible potentiation of warfarin by fluconazole
    • T. L. Seaton, C. L. Celum, and D. I. Black: Possible potentiation of warfarin by fluconazole. DICP 24, 1177-1178 (1990).
    • (1990) DICP , vol.24 , pp. 1177-1178
    • Seaton, T.L.1    Celum, C.L.2    Black, D.I.3
  • 8
    • 0026647577 scopus 로고
    • Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man
    • M. A. Touchette, P. H. Chandrasekar, M. A. Milad, and D. J. Edwards: Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man. Br. J. Clin. Pharmacol. 34, 75-78 (1992).
    • (1992) Br. J. Clin. Pharmacol. , vol.34 , pp. 75-78
    • Touchette, M.A.1    Chandrasekar, P.H.2    Milad, M.A.3    Edwards, D.J.4
  • 10
    • 0027284797 scopus 로고
    • Fluconazole-cyclosporine interaction: A dose dependent effect?
    • J. A. Lopez-Gil: Fluconazole-cyclosporine interaction: a dose dependent effect? Ann. Pharmacother. 27, 427-430 (1993).
    • (1993) Ann. Pharmacother. , vol.27 , pp. 427-430
    • Lopez-Gil, J.A.1
  • 11
    • 0027231225 scopus 로고
    • The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans
    • P. K. Honig, D. C. Wortham, K. Zamani, J. C. Millin, D. P. Conner, and L. R. Cantilena: The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans. Clin. Pharmacol. Ther. 53, 630-636 (1993).
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 630-636
    • Honig, P.K.1    Wortham, D.C.2    Zamani, K.3    Millin, J.C.4    Conner, D.P.5    Cantilena, L.R.6
  • 15
    • 0024403279 scopus 로고
    • Characteristics of warfarin hydroxylation catalyzed by human liver microsomes
    • A. E. Rettie, A. C. Eddy, L. D. Heimark, M. Gibaldi, and W. F. Trager: Characteristics of warfarin hydroxylation catalyzed by human liver microsomes. Drug Metab. Dispos. 17, 265-270 (1989).
    • (1989) Drug Metab. Dispos. , vol.17 , pp. 265-270
    • Rettie, A.E.1    Eddy, A.C.2    Heimark, L.D.3    Gibaldi, M.4    Trager, W.F.5
  • 17
    • 0027380074 scopus 로고
    • Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
    • K. L. Kunze and W. F. Trager: Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem. Res. Toxicol. 6, 649-656 (1993).
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 649-656
    • Kunze, K.L.1    Trager, W.F.2
  • 18
    • 0028008682 scopus 로고
    • Role of human microsomal and human complementary DNA-expressed cytochromes P450 1A2 and P450 3A4 in the bioactivation of aflatoxin B1
    • E. P. Gallagher, L. C. Wienkers, P. L. Stapleton, K. L. Kunze, and D. L. Eaton: Role of human microsomal and human complementary DNA-expressed cytochromes P450 1A2 and P450 3A4 in the bioactivation of aflatoxin B1. Cancer Res. 54, 101-108 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 101-108
    • Gallagher, E.P.1    Wienkers, L.C.2    Stapleton, P.L.3    Kunze, K.L.4    Eaton, D.L.5
  • 19
    • 0025646757 scopus 로고
    • Catalytic activities of human liver cytochrome P450 IIIA4 expressed in saccharomyces cerevisiae
    • W. B. Brian, M. A. Sari, M. Iwasaki, T. Shimada, L. S. Kaminsky, and F. P. Guengerich: Catalytic activities of human liver cytochrome P450 IIIA4 expressed in saccharomyces cerevisiae. Biochemistry 29, 11280-11292 (1990).
    • (1990) Biochemistry , vol.29 , pp. 11280-11292
    • Brian, W.B.1    Sari, M.A.2    Iwasaki, M.3    Shimada, T.4    Kaminsky, L.S.5    Guengerich, F.P.6
  • 20
    • 0027452620 scopus 로고
    • Correlation of human cytochrome P450 2C substrate specificities with primary structure: Warfarin as a probe
    • L. S. Kaminsky, S. M. de Morais, M. B. Faletto, D. A. Dunbar, and J. A. Goldstein: Correlation of human cytochrome P450 2C substrate specificities with primary structure: warfarin as a probe, Mol. Pharmacol. 43, 234-239 (1993).
    • (1993) Mol. Pharmacol. , vol.43 , pp. 234-239
    • Kaminsky, L.S.1    De Morais, S.M.2    Faletto, M.B.3    Dunbar, D.A.4    Goldstein, J.A.5
  • 21
    • 0015449999 scopus 로고
    • Absolute configuration of the four warfarin alcohols
    • K. K. Chan, R. J. Lewis, and W. F. Trager: Absolute configuration of the four warfarin alcohols. J. Med. Chem. 15, 1265-1270 (1972).
    • (1972) J. Med. Chem. , vol.15 , pp. 1265-1270
    • Chan, K.K.1    Lewis, R.J.2    Trager, W.F.3
  • 22
    • 0016817127 scopus 로고
    • Studies on a ketone reductase in human and rat liver and kidney soluble fraction using warfarin as a substrate
    • T. A. Moreland and D. S. Hewick: Studies on a ketone reductase in human and rat liver and kidney soluble fraction using warfarin as a substrate. Biochem. Pharmacol. 25, 1953-1957 (1975).
    • (1975) Biochem. Pharmacol. , vol.25 , pp. 1953-1957
    • Morel, T.A.1    Hewick, D.S.2
  • 23
    • 0022634457 scopus 로고
    • The synthesis of deuterium labelled metabolites of warfarin and phenprocoumon
    • L. D. Heimark, S. Toon, D. C. Swinney, and W. F. Trager: The synthesis of deuterium labelled metabolites of warfarin and phenprocoumon. J. Labelled Compd. Radiopharm. 23, 137-148 (1985).
    • (1985) J. Labelled Compd. Radiopharm. , vol.23 , pp. 137-148
    • Heimark, L.D.1    Toon, S.2    Swinney, D.C.3    Trager, W.F.4
  • 24
    • 0025352261 scopus 로고
    • Chemical synthesis, absolute configuration, and stereochemistry of 10-hydroxywarfarin: A major oxidative metabolite of (+)-(R)-warfarin from hepatic microsomal preparations
    • R. F. Lawrence, A. E. Rettie, A. C. Eddy, and W. F. Trager: Chemical synthesis, absolute configuration, and stereochemistry of 10-hydroxywarfarin: a major oxidative metabolite of (+)-(R)-warfarin from hepatic microsomal preparations. Chirality 2, 96-105 (1990).
    • (1990) Chirality , vol.2 , pp. 96-105
    • Lawrence, R.F.1    Rettie, A.E.2    Eddy, A.C.3    Trager, W.F.4
  • 25
    • 0027241257 scopus 로고
    • Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?
    • E. D. Kharasch and K. E. Thummel: Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance? Anesth. Analg. 26, 1033-1039 (1993).
    • (1993) Anesth. Analg. , vol.26 , pp. 1033-1039
    • Kharasch, E.D.1    Thummel, K.E.2
  • 27
    • 0023281142 scopus 로고
    • Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsomes
    • K. Lavrijsen, J. Van Houdt, D. Thijs, W. Meuldermans, and J. Heykants: Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsomes. Xenobiotica 17, 45-57 (1987).
    • (1987) Xenobiotica , vol.17 , pp. 45-57
    • Lavrijsen, K.1    Van Houdt, J.2    Thijs, D.3    Meuldermans, W.4    Heykants, J.5
  • 28
    • 0023610798 scopus 로고
    • Spectral and kinetic studies of the interaction of imidazole antifungal agents with microsomal cytochromes P450
    • A. D. Rodrigues, D. F. V. Lewis, C. Ionannides, and D. V. Parke: Spectral and kinetic studies of the interaction of imidazole antifungal agents with microsomal cytochromes P450. Xenobiotica 17, 1315-1327 (1987).
    • (1987) Xenobiotica , vol.17 , pp. 1315-1327
    • Rodrigues, A.D.1    Lewis, D.F.V.2    Ionannides, C.3    Parke, D.V.4
  • 29
    • 0023555592 scopus 로고
    • Interactions of imidazole antifungal agents with purified cytochrome P450 proteins
    • A. D. Rodrigues, G. G. Gibson, C. Ionannides, and D. V. Parke: Interactions of imidazole antifungal agents with purified cytochrome P450 proteins. Biochem. Pharmacol. 36, 4277-4281 (1987).
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 4277-4281
    • Rodrigues, A.D.1    Gibson, G.G.2    Ionannides, C.3    Parke, D.V.4
  • 30
    • 0025257110 scopus 로고
    • Pharmacokinetics and tissue penetration of fluconazole in humans
    • K. W. Brammer, P. R. Farrow, and J. K. Faulkner Pharmacokinetics and tissue penetration of fluconazole in humans. Rev. Infect. Dis. 12, S318-S326 (1990).
    • (1990) Rev. Infect. Dis. , vol.12
    • Brammer, K.W.1    Farrow, P.R.2    Faulkner, J.K.3
  • 34
    • 0015790825 scopus 로고
    • Plasma half-lives, plasma metabolites and the anticoagulant efficacies of the enantiomers of warfarin in man
    • D. S. Hewick and J. McEwen: Plasma half-lives, plasma metabolites and the anticoagulant efficacies of the enantiomers of warfarin in man. J. Pharm. Pharmacol. 25, 455-465 (1973).
    • (1973) J. Pharm. Pharmacol. , vol.25 , pp. 455-465
    • Hewick, D.S.1    McEwen, J.2
  • 35
    • 0016220245 scopus 로고
    • Studies of the optical enantiomorphs of warfarin in man
    • R. A. O'Reilly: Studies of the optical enantiomorphs of warfarin in man. Clin. Pharmacol Ther. 16, 348-354 (1974).
    • (1974) Clin. Pharmacol Ther. , vol.16 , pp. 348-354
    • O'Reilly, R.A.1


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