Enhanced antitumor activities of TZT-1027 against TNF-α or IL-6 secreting lewis lung carcinoma in vivo

Cancer Chemotherapy and Pharmacology

Volumn 49, Issue 1, 2002, Pages 35-47

  Natsume, Tsugitaka ^a   Koh, Yasuhiro ^b   Kobayashi, Motohiro ^a   Fukumoto, Hisao ^b   Takahashi, Fumiyuki ^b   Nakamura, Takashi ^b   Ohe, Yuichiro ^c   Saijo, Nagahiro ^c   Nishio, Kazuto ^b  

^a Grelan Pharmaceutical Co Ltd   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Angiogenesis; IL 6; Macroarray; TNF ; TZT 1027

Indexed keywords

ANTIBODY; AURISTATIN PE; CD31 ANTIGEN; CHROMOSOME PROTEIN; CYTOKINE; HEAT SHOCK PROTEIN; INTERLEUKIN 6; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; COMPLEMENTARY DNA; HIGH MOBILITY GROUP N1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSFECTION; GROWTH INHIBITION; HOMEOBOX; INOCULATION; LEWIS CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VASCULARIZATION; ANGIOGENESIS; ANTIBODY LABELING; CANCER CELL DESTRUCTION; CANCER GROWTH; DNA MICROARRAY; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG CARCINOMA; MULTIGENE FAMILY; NITROBLUE TETRAZOLIUM TEST;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, LEWIS LUNG; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; LLC-PK1 CELLS; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGOPEPTIDES; RNA, NEOPLASM; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036140378     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-001-0388-0     Document Type: Article

References (53)

1. Interleukin 6 differentially potentiates the antitumor effects of Taxol and vinblastine in U266 human myeloma
2. Inhibition of the growth of colon 38 adenocarcinoma by vinblastine and colchicine: Evidence for a vascular mechanism
3. A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and isolated mononucleosomes
4. Synergistic cytotoxicity of human recombinant tumor necrosis factor α combined with microtubule effectors
5. Expression and modulation of homeobox genes from cluster B in endothelial cells
6. Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages
7. The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: Synergy with interleukin-2 and modulation of interleukin-2Rγ chain expression
8. Induction of the angiogenic phenotype by Hox D3
9. Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents
10. Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta
11. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
12. Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase
13. Dual role of tumor necrosis factor-α in angiogenesis
14. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
15. Angiogenesis and prostate cancer: In vivo and in vitro expression of angiogenesis factors by prostate cancer cells
16. Interferon-γ-inducing factor gene transfection into Lewis lung carcinoma cells reduces tumorigenicity in vivo
17. Genetic immunotherapy by intrapleural, intra peritoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells
18. Vinca alkaloids: Anti-vascular effects in a murine tumour
19. Antitumor effects due to irreversible stoppage of tumor tissue blood flow: Evaluation of a novel combretastatin A-4 derivative, AC7700
20. Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells
21. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
22. CD14 is not involved in Rhodobacter sphaeroides diphosphoryl lipid A inhibition of tumor necrosis factor alpha and nitric oxide induction by Taxol in murine macrophages
23. Antitumor activity of TZT-1027, a novel dolastatin 10 derivative
24. The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation
25. Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape. A tubulin-driven process
26. p53 independent apoptosis induced by paclitaxel through an indirect mechanism
27. In vitro assembly of multiprotein complexes containing α, β, and γ tubulin, heat shock protein HSP70, and elongation factor 1 α
28. Effect of tumor necrosis factor and epidermal growth factor on cell morphology, cell surface receptors, and the production of tissue inhibitors of metalloproteinases and IL-6 in human microvascular endothelial cells
29. Drug treatments for metastasis of the Lewis lung carcinoma: Lack of correlation between inhibition of lung metastasis and survival
30. AIDS Kaposi sarcomaderived cells produce and respond to interleukin-6
31. Synthesis and antitumor activity of novel dolastatin 10 analogs
32. Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma
33. Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1
34. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
35. Taxolmediated changes in fibrosarcoma-induced immune cell function: Modulation of antitumor activities
36. Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin
37. Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes
38. A regulatory element that mediates co-operation between a PEA3-AP-1 element and AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells
39. Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy
40. Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumor growth rate but cause weight loss and shorten survival in syngenic mice
41. Combination effect of vaccination with IL2 and IL4 cDNA transfected cells on the induction of a therapeutic immune response against Lewis lung carcinoma cells
42. Gene therapy for Lewis lung carcinoma with tumor necrosis factor and interleukin 2 cDNAs co-transfected subline
43. Endogenous basic fibroblast growth factor-dependent induction of collagenase and interleukin-6 in tumor necrosis factor-treated human microvascular endothelial cells
44. TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death
45. Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients
46. Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells
47. Recombinant human tumor necrosis factor- α: Thrombus formation is a cause of anti-tumor activity
48. Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53
49. Studies in a tumor spectrum III. The effect of phosphoramides on the growth of a variety of mouse and rat
50. Complementary patterns of expression of c-ets-1, c-myb and c-myc in the blood-forming system of the chick embryo
51. Does the transcription factor c-ets-1 take part in the regulation of angiogenesis and tumor invasion?
52. Induction of apoptosis in human cancer cells by TZT-1027, an antimicrotubule agent
53. Effects of TNF alone or in combination with chemotherapeutic agents on human ovarian cancers in vitro and in nude mice