Role of CD8+ T lymphocytes in control of Mycobacterium tuberculosis infection

Microbes and Infection

Volumn 7, Issue 4, 2005, Pages 776-788

  Grotzke, Jeff E ^a   Lewinsohn, David M ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Antigen presentation; CD8 positive T lymphocytes; Immunologic surveillance; Tuberculosis

Indexed keywords

BCG VACCINE; BREFELDIN A; CD1 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; GAMMA INTERFERON; MYCOBACTERIUM VACCINE; REACTIVE NITROGEN SPECIES; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

CELL FUNCTION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; GENE EXPRESSION; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSURVEILLANCE; INFECTION CONTROL; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE; TH1 CELL; TUBERCULOSIS;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 19344364800     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2005.03.001     Document Type: Short Survey

References (114)

1. Global Tuberculosis Control: Surveillance, Planning, Financing. WHO report 2004, Geneva, Switzerland, 2004.
2. T. Lietman, and S.M. Blower Potential impact of tuberculosis vaccines as epidemic control agents Clin. Infect. Dis. 30 Suppl. 3 2000 S316 S322
3. R. Hernandez-Pando, M. Jeyanathan, G. Mengistu, D. Aguilar, H. Orozco, and M. Harboe Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection Lancet 356 2000 2133 2138
4. T. Lillebaek, A. Dirksen, I. Baess, B. Strunge, V.O. Thomsen, and A.B. Andersen Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33:years of latent infection J. Infect. Dis. 185 2002 401 404
5. J.L. Casanova, and L. Abel Genetic dissection of immunity to mycobacteria: the human model Annu. Rev. Immunol. 20 2002 581 620
6. J.M. Tufariello, J. Chan, and J.L. Flynn Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection Lancet Infect. Dis. 3 2003 578 590
7. J. Keane, S. Gershon, R.P. Wise, E. Mirabile-Levens, J. Kasznica, and W.D. Schwieterman Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent New Engl. J. Med. 345 2001 1098 1104
8. I. Muller, S.P. Cobbold, H. Waldmann, and S.H. Kaufmann Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells Infect. Immun. 55 1987 2037 2041
9. C. Leveton, S. Barnass, B. Champion, S. Lucas, B. De Souza, and M. Nicol T-cell-mediated protection of mice against virulent Mycobacterium tuberculosis Infect. Immun. 57 1989 390 395
10. C.M. Flory, R.D. Hubbard, and F.M. Collins Effects of in vivo T lymphocyte subset depletion on mycobacterial infections in mice J. Leukocyte Biol. 51 1992 225 229
11. A.M. Caruso, N. Serbina, E. Klein, K. Triebold, B.R. Bloom, and J.L. Flynn Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis J. Immunol. 162 1999 5407 5416
12. J.M. Wallace, N.I. Hansen, L. Lavange, J. Glassroth, B.L. Browdy, and M.J. Rosen Respiratory disease trends in the Pulmonary Complications of HIV Infection Study cohort. Pulmonary Complications of HIV Infection Study Group Am. J. Respir. Crit. Care Med. 155 1997 72 80
13. A.M. Cooper, D.K. Dalton, T.A. Stewart, J.P. Griffin, D.G. Russell, and I.M. Orme Disseminated tuberculosis in interferon gamma gene-disrupted mice J. Exp. Med. 178 1993 2243 2247
14. J.L. Flynn, J. Chan, K.J. Triebold, D.K. Dalton, T.A. Stewart, and B.R. Bloom An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection J. Exp. Med. 178 1993 2249 2254
15. S.E. Dorman, and S.M. Holland Interferon-gamma and interleukin-12 pathway defects and human disease Cytokine Growth Factor Rev. 11 2000 321 333
16. R. Condos, W.N. Rom, and N.W. Schluger Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol Lancet 349 1997 1513 1515
17. S.M. Holland Immunotherapy of mycobacterial infections Semin. Respir. Infect. 16 2001 47 59
18. S.M. Holland, E.M. Eisenstein, D.B. Kuhns, M.L. Turner, T.A. Fleisher, and W. Strober Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. A preliminary report New Engl. J. Med. 330 1994 1348 1355
19. A. Sodhi, J. Gong, C. Silva, D. Qian, and P.F. Barnes Clinical correlates of interferon gamma production in patients with tuberculosis Clin. Infect. Dis. 25 1997 617 620
20. C.S. Hirsch, Z. Toossi, C. Othieno, J.L. Johnson, S.K. Schwander, and S. Robertson Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy J. Infect. Dis. 180 1999 2069 2073
21. J.L. Flynn, M.M. Goldstein, J. Chan, K.J. Triebold, K. Pfeffer, and C.J. Lowenstein Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice Immunity 2 1995 561 572
22. T. Mogues, M.E. Goodrich, L. Ryan, R. LaCourse, and R.J. North The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice J. Exp. Med. 193 2001 271 280
23. J.D. MacMicking, R.J. North, R. LaCourse, J.S. Mudgett, S.K. Shah, and C.F. Nathan Identification of nitric oxide synthase as a protective locus against tuberculosis Proc. Natl. Acad. Sci. USA 94 1997 5243 5248
24. H.S. Choi, P.R. Rai, H.W. Chu, C. Cool, and E.D. Chan Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis Am. J. Respir. Crit. Care Med. 166 2002 178 186
25. + T lymphocytes Nature 421 2003 852 856
26. D.J. Shedlock, and H. Shen Requirement for CD4 T cell help in generating functional CD8 T cell memory Science 300 2003 337 339
27. J.C. Sun, and M.J. Bevan Defective CD8 T cell memory following acute infection without CD4 T cell help Science 300 2003 339 342
28. + T cells after acute infection Nat. Immunol. 5 2004 927 933
29. + T-cell-deficient mice J. Virol. 68 1994 4700 4704
30. + T cells J. Exp. Med. 184 1996 863 871
31. + cytotoxic T-cell responses during chronic viral infection J. Virol. 68 1994 8056 8063
32. A.R. Thomsen, J. Johansen, O. Marker, and J.P. Christensen Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice J. Immunol. 157 1996 3074 3080
33. M.G. von Herrath, M. Yokoyama, J. Dockter, M.B. Oldstone, and J.L. Whitton CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge J. Virol. 70 1996 1072 1079
34. N.V. Serbina, and J.L. Flynn Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice Infect. Immun. 67 1999 3980 3988
35. M. Gonzalez-Juarrero, O.C. Turner, J. Turner, P. Marietta, J.V. Brooks, and I.M. Orme Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis Infect. Immun. 69 2001 1722 1728
36. I.M. Orme Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection J. Immunol. 140 1988 3589 3593
37. I.M. Orme The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis J. Immunol. 138 1987 293 298
38. G. De Libero, I. Flesch, and S.H. Kaufmann Mycobacteria-reactive Lyt-2+ T cell lines Eur. J. Immunol. 18 1988 59 66
39. V.L. Bonato, V.M. Lima, R.E. Tascon, D.B. Lowrie, and C.L. Silva Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice Infect. Immun. 66 1998 169 175
40. H. McShane, S. Behboudi, N. Goonetilleke, R. Brookes, and A.V. Hill Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A Infect. Immun. 70 2002 1623 1626
41. J.L. Flynn, M.M. Goldstein, K.J. Triebold, B. Koller, and B.R. Bloom Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection Proc. Natl. Acad. Sci. USA 89 1992 12013 12017
42. U.E. Schaible, H.L. Collins, F. Priem, and S.H. Kaufmann Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis J. Exp. Med. 196 2002 1507 1513
43. S.M. Behar, C.C. Dascher, M.J. Grusby, C.R. Wang, and M.B. Brenner Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis J. Exp. Med. 189 1999 1973 1980
44. A.O. Sousa, R.J. Mazzaccaro, R.G. Russell, F.K. Lee, O.C. Turner, and S. Hong Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice Proc. Natl. Acad. Sci. USA 97 2000 4204 4208
45. M.S. Rolph, B. Raupach, H.H. Kobernick, H.L. Collins, B. Perarnau, and F.A. Lemonnier MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis Eur. J. Immunol. 31 2001 1944 1949
46. N.V. Serbina, V. Lazarevic, and J.L. Flynn CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection J. Immunol. 167 2001 6991 7000
47. S. Stenger, D.A. Hanson, R. Teitelbaum, P. Dewan, K.R. Niazi, and C.J. Froelich An antimicrobial activity of cytolytic T cells mediated by granulysin Science 282 1998 121 125
48. + T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction J. Immunol. 165 2000 925 930
49. + T cells J. Exp. Med. 196 2002 1473 1481
50. S. Sturgill-Koszycki, P.H. Schlesinger, P. Chakraborty, P.L. Haddix, H.L. Collins, and A.K. Fok Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase Science 263 1994 678 681
51. D.L. Clemens, and M.A. Horwitz Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited J. Exp. Med. 181 1995 257 270
52. M. Kovacsovics-Bankowski, and K.L. Rock A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules Science 267 1995 243 246
53. R.J. Mazzaccaro, M. Gedde, E.R. Jensen, H.M. Van Santen, H.L. Ploegh, and K.L. Rock Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection Proc. Natl. Acad. Sci. USA 93 1996 11786 11791
54. R. Teitelbaum, M. Cammer, M.L. Maitland, N.E. Freitag, J. Condeelis, and B.R. Bloom Mycobacterial infection of macrophages results in membrane-permeable phagosomes Proc. Natl. Acad. Sci. USA 96 1999 15190 15195
55. U.E. Schaible, F. Winau, P.A. Sieling, K. Fischer, H.L. Collins, and K. Hagens Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis Nat. Med. 9 2003 1039 1046
56. P. Guermonprez, L. Saveanu, M. Kleijmeer, J. Davoust, P. Van Endert, and S. Amigorena ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells Nature 425 2003 397 402
57. M. Houde, S. Bertholet, E. Gagnon, S. Brunet, G. Goyette, and A. Laplante Phagosomes are competent organelles for antigen cross-presentation Nature 425 2003 402 406
58. A.L. Ackerman, C. Kyritsis, R. Tampe, and P. Cresswell Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens Proc. Natl. Acad. Sci. USA 100 2003 12889 12894
59. E. Gagnon, S. Duclos, C. Rondeau, E. Chevet, P.H. Cameron, and O. Steele-Mortimer Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages Cell 110 2002 119 131
60. + T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells J. Exp. Med. 187 1998 1633 1640
61. + alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway J. Immunol. 162 1999 372 379
62. R. Song, and C.V. Harding Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway J. Immunol. 156 1996 4182 4190
63. J.D. Pfeifer, M.J. Wick, R.L. Roberts, K. Findlay, S.J. Normark, and C.V. Harding Phagocytic processing of bacterial antigens for class I MHC presentation to T cells Nature 361 1993 359 362
64. P.J. Chefalo, and C.V. Harding Processing of exogenous antigens for presentation by class I MHC molecules involves post-Golgi peptide exchange influenced by peptide-MHC complex stability and acidic pH J. Immunol. 167 2001 1274 1282
65. L. Shen, L.J. Sigal, M. Boes, and K.L. Rock Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo Immunity 21 2004 155 165
66. W.L. Beatty, E.R. Rhoades, H.J. Ullrich, D. Chatterjee, J.E. Heuser, and D.G. Russell Trafficking and release of mycobacterial lipids from infected macrophages Traffic 1 2000 235 247
67. W.L. Beatty, and D.G. Russell Identification of mycobacterial surface proteins released into subcellular compartments of infected macrophages Infect. Immun. 68 2000 6997 7002
68. W.L. Beatty, H.J. Ullrich, and D.G. Russell Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event Eur. J. Cell Biol. 80 2001 31 40
69. O. Neyrolles, K. Gould, M.P. Gares, S. Brett, R. Janssen, and P. O'Gaora Lipoprotein access to MHC class I presentation during infection of murine macrophages with live mycobacteria J. Immunol. 166 2001 447 457
70. J.W. Yewdell, and J.R. Bennink Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses Annu. Rev. Immunol. 17 1999 51 88
71. D.C. Flyer, V. Ramakrishna, C. Miller, H. Myers, M. McDaniel, and K. Root Identification by mass spectrometry of CD8(+)-T-cell Mycobacterium tuberculosis epitopes within the Rv0341 gene product Infect. Immun. 70 2002 2926 2932
72. M.R. Klein, A.S. Hammond, S.M. Smith, A. Jaye, P.T. Lukey, and K.P. McAdam HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c Infect. Immun. 70 2002 981 984
73. N. Caccamo, S. Milano, C. Di Sano, D. Cigna, J. Ivanyi, and A.M. Krensky Identification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A*0201 CD8(+) T lymphocytes J. Infect. Dis. 186 2002 991 998
74. + T cells in HLA-transgenic mice and humans J. Immunol. 165 2000 6463 6471
75. + T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection J. Exp. Med. 200 2004 1479 1489
76. D.H. Canaday, R.J. Wilkinson, Q. Li, C.V. Harding, R.F. Silver, and W.H. Boom CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism J. Immunol. 167 2001 2734 2742
77. + T cells use both CD95-dependent and CD95-independent cytolytic mechanisms J. Immunol. 160 1998 2374 2379
78. + T cells preferentially recognize heavily infected cells Am. J. Respir. Crit. Care Med. 168 2003 1346 1352
79. J. Turner, C.D. D'Souza, J.E. Pearl, P. Marietta, M. Noel, and A.A. Frank CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis Am. J. Respir. Cell Mol. Biol. 24 2001 203 209
80. J. Spielman, R.K. Lee, and E.R. Podack Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis J. Immunol. 161 1998 7063 7070
81. + T cells clear influenza virus by perforin or Fas-dependent processes J. Immunol. 159 1997 5197 5200
82. C. Fratazzi, R.D. Arbeit, C. Carini, M.K. Balcewicz-Sablinska, J. Keane, and H. Kornfeld Macrophage apoptosis in mycobacterial infections J. Leukocyte Biol. 66 1999 763 764
83. A. Molloy, P. Laochumroonvorapong, and G. Kaplan Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular Bacillus Calmette-Guerin J. Exp. Med. 180 1994 1499 1509
84. J. Keane, H.G. Remold, and H. Kornfeld Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages J. Immunol. 164 2000 2016 2020
85. M.K. Balcewicz-Sablinska, J. Keane, H. Kornfeld, and H.G. Remold Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha J. Immunol. 161 1998 2636 2641
86. L.A. Van Pinxteren, J.P. Cassidy, B.H. Smedegaard, E.M. Agger, and P. Andersen Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells Eur. J. Immunol. 30 2000 3689 3698
87. K.M. Kerksiek, D.H. Busch, I.M. Pilip, S.E. Allen, and E.G. Pamer H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses J. Exp. Med. 190 1999 195 204
88. K.B. Urdahl, J.C. Sun, and M.J. Bevan Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells Nat. Immunol. 3 2002 772 779
89. T. Kawashima, Y. Norose, Y. Watanabe, Y. Enomoto, H. Narazaki, and E. Watari Cutting edge: major CD8 T cell response to live Bacillus Calmette-Guerin is mediated by CD1 molecules J. Immunol. 170 2003 5345 5348
90. T. Ulrichs, D.B. Moody, E. Grant, S.H. Kaufmann, and S.A. Porcelli T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection Infect. Immun. 71 2003 3076 3087
91. D.B. Moody, T. Ulrichs, W. Muhlecker, D.C. Young, S.S. Gurcha, and E. Grant CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection Nature 404 2000 884 888
92. E.M. Beckman, S.A. Porcelli, C.T. Morita, S.M. Behar, S.T. Furlong, and M.B. Brenner Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells Nature 372 1994 691 694
93. P.A. Sieling, D. Chatterjee, S.A. Porcelli, T.I. Prigozy, R.J. Mazzaccaro, and T. Soriano CD1-restricted T cell recognition of microbial lipoglycan antigens Science 269 1995 227 230
94. D.B. Moody, B.B. Reinhold, M.R. Guy, E.M. Beckman, D.E. Frederique, and S.T. Furlong Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells Science 278 1997 283 286
95. D.B. Moody, D.C. Young, T.Y. Cheng, J.P. Rosat, C. Roura-Mir, and P.B. O'Connor T cell activation by lipopeptide antigens Science 303 2004 527 531
96. U.E. Schaible, K. Hagens, K. Fischer, H.L. Collins, and S.H. Kaufmann Intersection of group I CD1 molecules and mycobacteria in different intracellular compartments of dendritic cells J. Immunol. 164 2000 4843 4852
97. S. Stenger, R.J. Mazzaccaro, K. Uyemura, S. Cho, P.F. Barnes, and J.P. Rosat Differential effects of cytolytic T cell subsets on intracellular infection Science 276 1997 1684 1687
98. K. Hiromatsu, C.C. Dascher, K.P. LeClair, M. Sugita, S.T. Furlong, and M.B. Brenner Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens J. Immunol. 169 2002 330 339
99. A. Chackerian, J. Alt, V. Perera, and S.M. Behar Activation of NKT cells protects mice from tuberculosis Infect. Immun. 70 2002 6302 6309
100. K. Fischer, E. Scotet, M. Niemeyer, H. Koebernick, J. Zerrahn, and S. Maillet Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells Proc. Natl. Acad. Sci. USA 101 2004 10685 10690
101. J.L. Gansert, V. Kiessler, M. Engele, F. Wittke, M. Rollinghoff, and A.M. Krensky Human NKT cells express granulysin and exhibit antimycobacterial activity J. Immunol. 170 2003 3154 3161
102. T. Chun, N.V. Serbina, D. Nolt, B. Wang, N.M. Chiu, and J.L. Flynn Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis J. Exp. Med. 193 2001 1213 1220
103. + cytolytic T lymphocytes Proc. Natl. Acad. Sci. USA 100 2003 10896 10901
104. + T cell subset in volunteers immunized with Salmonella enterica serovar typhi strain Ty21a typhoid vaccine J. Immunol. 173 2004 5852 5862
105. W.F. Lo, A.S. Woods, A. DeCloux, R.J. Cotter, E.S. Metcalf, and M.J. Soloski Molecular mimicry mediated by MHC class Ib molecules after infection with gram-negative pathogens Nat. Med. 6 2000 215 218
106. A. Van Rie, R. Warren, M. Richardson, T.C. Victor, R.P. Gie, and D.A. Enarson Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment New Engl. J. Med. 341 1999 1174 1179
107. N. Mohagheghpour, D. Gammon, L.M. Kawamura, A. Van Vollenhoven, C.J. Benike, and E.G. Engleman CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein J. Immunol. 161 1998 2400 2406
108. S.M. Smith, M.R. Klein, A.S. Malin, J. Sillah, K. Huygen, and P. Andersen Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia Infect. Immun. 68 2000 7144 7148
109. M.R. Klein, S.M. Smith, A.S. Hammond, G.S. Ogg, A.S. King, and J. Vekemans HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis J. Infect. Dis. 183 2001 928 934
110. + T lymphocytes specific for Mycobacterium tuberculosis Proc. Natl. Acad. Sci. USA 95 1998 270 275
111. A.A. Pathan, K.A. Wilkinson, R.J. Wilkinson, M. Latif, H. McShane, and G. Pasvol High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease Eur. J. Immunol. 30 2000 2713 2721
112. + T lymphocytes derived from Mycobacterium tuberculosis-infected cells: definition of antigenic specificity J. Immunol. 166 2001 439 446
113. J. Charo, A. Geluk, M. Sundback, B. Mirzai, A.D. Diehl, and K.J. Malmberg The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65 Eur. J. Immunol. 31 2001 3602 3611
114. + T cells Am. J. Respir. Crit. Care Med. 166 2002 843 848