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Volumn 7, Issue 7, 2001, Pages 433-441

Association between Uncoupling Protéin 3 Gene and Obesity-related Phenotypes in the Québec Family Study

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GLUCOSE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3;

EID: 0035404879     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401848     Document Type: Article
Times cited : (34)

References (41)
  • 1
    • 0028322089 scopus 로고
    • Increasing prevalence of overweight among US adults. the National Health and Nutrition Examination Surveys, 1960 to 1991
    • Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. (1994) Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 272: 205-211.
    • (1994) JAMA , vol.272 , pp. 205-211
    • Kuczmarski, R.J.1    Flegal, K.M.2    Campbell, S.M.3    Johnson, C.L.4
  • 2
    • 0026507487 scopus 로고
    • Pathophysiology of obesity
    • Bray GA. (1992) Pathophysiology of obesity. Am. J. Clin. Nutr. 55(2 Suppl): 488S-494S.
    • (1992) Am. J. Clin. Nutr. , vol.55 , Issue.2 SUPPL.
    • Bray, G.A.1
  • 3
    • 0001060852 scopus 로고
    • Genetics of obesity: Overview and research directions
    • C. Bouchard, ed. Boca Raton, FL: CRC Press
    • Bouchard C. (1994) Genetics of obesity: overview and research directions. In: C. Bouchard, ed. The Genetics of Obesity. Boca Raton, FL: CRC Press, pp. 223-233.
    • (1994) The Genetics of Obesity , pp. 223-233
    • Bouchard, C.1
  • 4
    • 0025861442 scopus 로고
    • The uncoupling protein UCP: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue
    • Klaus S, Casteilla L, Bouillaud F, Ricquier D. (1991). The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int. J. Biochem. 23: 791-801.
    • (1991) Int. J. Biochem. , vol.23 , pp. 791-801
    • Klaus, S.1    Casteilla, L.2    Bouillaud, F.3    Ricquier, D.4
  • 5
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury C, Neverova M, Collins S, et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15: 269-272.
    • (1997) Nat. Genet. , vol.15 , pp. 269-272
    • Fleury, C.1    Neverova, M.2    Collins, S.3
  • 6
    • 0030988140 scopus 로고    scopus 로고
    • Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
    • Boss O, Samec S, Paoloni-Giacobino A, et al. (1997) Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408: 39-42.
    • (1997) FEBS Lett. , vol.408 , pp. 39-42
    • Boss, O.1    Samec, S.2    Paoloni-Giacobino, A.3
  • 7
    • 0033524853 scopus 로고    scopus 로고
    • Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene
    • Pecqueur C, Cassard-Doulcier AM, Raimbault S, et al. (1999) Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene. Biochem. Btophys. Res. Commun. 255: 40-46.
    • (1999) Biochem. Btophys. Res. Commun. , vol.255 , pp. 40-46
    • Pecqueur, C.1    Cassard-Doulcier, A.M.2    Raimbault, S.3
  • 8
    • 0033392902 scopus 로고    scopus 로고
    • Uncoupling protein 3: Its possible biological role and mode of regulation in rodents and humans
    • Muzzin P, Boss O, Giacobino JP. (1999) Uncoupling protein 3: its possible biological role and mode of regulation in rodents and humans. J. Bioenerg. Biomembr. 31: 467-473.
    • (1999) J. Bioenerg. Biomembr. , vol.31 , pp. 467-473
    • Muzzin, P.1    Boss, O.2    Giacobino, J.P.3
  • 9
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    • Gong DW, He Y, Karas M, Reitman M. (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J. Biol. Chem. 272: 24129-24132.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 10
    • 0027732707 scopus 로고
    • Contribution of skeletal muscle and adipose tissue to adrenaline-induced thermogenesis in man
    • discussion S68
    • Simonsen L, Stallknecht B, Bulow J. (1993) Contribution of skeletal muscle and adipose tissue to adrenaline-induced thermogenesis in man. Int. J. Obes. Relat. Metab. Disord. 17(Suppl 3): S47-S51; discussion S68.
    • (1993) Int. J. Obes. Relat. Metab. Disord. , vol.17 , Issue.3 SUPPL.
    • Simonsen, L.1    Stallknecht, B.2    Bulow, J.3
  • 11
    • 0006877856 scopus 로고    scopus 로고
    • Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    • Clapham J, Arch J, Chapman H, et al. (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406: 415-418.
    • (2000) Nature , vol.406 , pp. 415-418
    • Clapham, J.1    Arch, J.2    Chapman, H.3
  • 12
    • 0034717015 scopus 로고    scopus 로고
    • Energy metabolism in uncoupling protein 3 gene knockout mice
    • Vidal-Puig AJ, Grujic D, Zhang CY, et al. (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J. Biol. Chem. 275: 16258-16266.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16258-16266
    • Vidal-Puig, A.J.1    Grujic, D.2    Zhang, C.Y.3
  • 13
    • 0034717074 scopus 로고    scopus 로고
    • Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    • Gong D, Monemdjou S, Gavrilova O, et al. (2000) Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J. Biol. Chem. 275: 16251-16257.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16251-16257
    • Gong, D.1    Monemdjou, S.2    Gavrilova, O.3
  • 14
    • 0031832185 scopus 로고    scopus 로고
    • Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
    • Samec S, Seydoux J, Dulloo AG. (1998) Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J. 12: 715-724.
    • (1998) FASEB J. , vol.12 , pp. 715-724
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 15
    • 0033972895 scopus 로고    scopus 로고
    • Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue
    • Khalfallah Y, Fages S, Laville M, Langin D, Vidai H. (2000) Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue. Diabetes 49: 25-31.
    • (2000) Diabetes , vol.49 , pp. 25-31
    • Khalfallah, Y.1    Fages, S.2    Laville, M.3    Langin, D.4    Vidai, H.5
  • 16
    • 0033867371 scopus 로고    scopus 로고
    • Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans
    • Comuzzie AG, Almasy L, Cole SA, et al. (2000) Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans. Int. J. Obes. Relat. Metab. Disord. 24: 1065-1068.
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 1065-1068
    • Comuzzie, A.G.1    Almasy, L.2    Cole, S.A.3
  • 17
    • 0032933115 scopus 로고    scopus 로고
    • Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians
    • Schrauwen P, Xia J, Bogardus C, Pratley RE, Ravussin E. (1999) Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes 48: 146-149.
    • (1999) Diabetes , vol.48 , pp. 146-149
    • Schrauwen, P.1    Xia, J.2    Bogardus, C.3    Pratley, R.E.4    Ravussin, E.5
  • 18
    • 0032189845 scopus 로고    scopus 로고
    • Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
    • Argyropoulos G, Brown AM, Willi SM, et al. (1998) Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J. Clin Invest. 102: 1345-1351.
    • (1998) J. Clin Invest. , vol.102 , pp. 1345-1351
    • Argyropoulos, G.1    Brown, A.M.2    Willi, S.M.3
  • 19
    • 0032884928 scopus 로고    scopus 로고
    • Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis
    • Chung W, Luke A, Cooper R, et al. (1999) Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis. Diabetes 48: 1890-1895.
    • (1999) Diabetes , vol.48 , pp. 1890-1895
    • Chung, W.1    Luke, A.2    Cooper, R.3
  • 20
    • 0031912624 scopus 로고    scopus 로고
    • Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity
    • Urhammer SA, Dalgaard LT, Sorensen TI, et al. (1998) Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity. Diabetologia 41: 241-244.
    • (1998) Diabetologia , vol.41 , pp. 241-244
    • Urhammer, S.A.1    Dalgaard, L.T.2    Sorensen, T.I.3
  • 21
    • 7344220905 scopus 로고    scopus 로고
    • Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians
    • Walder K, Norman RA, Hanson RL, et al. (1998) Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians. Hum. Mol. Genet. 7: 1431-1435.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1431-1435
    • Walder, K.1    Norman, R.A.2    Hanson, R.L.3
  • 22
    • 0032932815 scopus 로고    scopus 로고
    • Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients
    • Otabe S, Clement K, Dubois S, et al. (1999) Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients. Diabetes 48: 206-208.
    • (1999) Diabetes , vol.48 , pp. 206-208
    • Otabe, S.1    Clement, K.2    Dubois, S.3
  • 23
    • 0034003721 scopus 로고    scopus 로고
    • A genetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
    • Otabe S, Clement K, Dina C, et al. (2000) A genetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia 43: 245-249.
    • (2000) Diabetologia , vol.43 , pp. 245-249
    • Otabe, S.1    Clement, K.2    Dina, C.3
  • 24
    • 0000573065 scopus 로고    scopus 로고
    • Genetic epidemiology, association and sib-pair linkage: Results from the Quebec Family Study
    • Bray GA, ed. Baton Rouge: Louisiana State University Press
    • Bouchard C. (1996) Genetic epidemiology, association and sib-pair linkage: results from the Quebec Family Study. In: Bray GA, ed. Molecular and Genetic Aspects of Obesity. Baton Rouge: Louisiana State University Press, pp. 470-481.
    • (1996) Molecular and Genetic Aspects of Obesity , pp. 470-481
    • Bouchard, C.1
  • 26
    • 77049310862 scopus 로고
    • The gross composition of the body
    • Lawrence JH, Tobias CA, ed. New York: Academic Press
    • Siri WE. (1976) The gross composition of the body. In: Lawrence JH, Tobias CA, ed. Advances in Biological and Medical Physics. New York: Academic Press, pp. 239-280.
    • (1976) Advances in Biological and Medical Physics , pp. 239-280
    • Siri, W.E.1
  • 27
    • 0028203814 scopus 로고
    • DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat
    • Deriaz O, Dionne F, Perusse L, et al. (1994) DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat. J. Clin. Invest. 93: 838-843.
    • (1994) J. Clin. Invest. , vol.93 , pp. 838-843
    • Deriaz, O.1    Dionne, F.2    Perusse, L.3
  • 28
    • 0015146643 scopus 로고
    • Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays
    • Desbuquois B, Aurbach GD. (1971) Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J. Clin. Endocrinol. Metab. 33: 732-738.
    • (1971) J. Clin. Endocrinol. Metab. , vol.33 , pp. 732-738
    • Desbuquois, B.1    Aurbach, G.D.2
  • 29
    • 0015058419 scopus 로고
    • Determination of plasma glucose by hexokinase-glucose-6-phosphate dehydrogenase method
    • Richterich R, Dauwalder H. (1971) [Determination of plasma glucose by hexokinase-glucose-6-phosphate dehydrogenase method]. Schweiz Med. Wochenschr. 101: 615-618.
    • (1971) Schweiz Med. Wochenschr. , vol.101 , pp. 615-618
    • Richterich, R.1    Dauwalder, H.2
  • 30
    • 0032006068 scopus 로고    scopus 로고
    • Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13
    • Boss O, Giacobino JP, Muzzin P. (1998) Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13. Genomics 47: 425-426.
    • (1998) Genomics , vol.47 , pp. 425-426
    • Boss, O.1    Giacobino, J.P.2    Muzzin, P.3
  • 31
    • 17744381149 scopus 로고    scopus 로고
    • Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    • Chagnon YC, Wilmore JH, Borecki IB, et ai. (2000) Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J. Clin. Endocrinol. Metab. 85: 29-34.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 29-34
    • Chagnon, Y.C.1    Wilmore, J.H.2    Borecki, I.B.3
  • 32
    • 0034076314 scopus 로고    scopus 로고
    • Linkage and association studies of the lipoprotein lipase gene with postheparin plasma lipase activities, body fat, and plasma lipid and lipoprotein concentrations: The HERITAGE Family Study
    • Garenc C, Perusse L, Gagnon J, et al. (2000) Linkage and association studies of the lipoprotein lipase gene with postheparin plasma lipase activities, body fat, and plasma lipid and lipoprotein concentrations: the HERITAGE Family Study. Metabolism 49: 432-439.
    • (2000) Metabolism , vol.49 , pp. 432-439
    • Garenc, C.1    Perusse, L.2    Gagnon, J.3
  • 33
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1: 1155-1161.
    • (1995) Nat. Med. , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 34
    • 0034434968 scopus 로고    scopus 로고
    • Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin
    • Cassell PG, Saker PJ, Huxtable SJ, et al. (2000) Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin. Diabetologia 43: 1558-1564.
    • (2000) Diabetologia , vol.43 , pp. 1558-1564
    • Cassell, P.G.1    Saker, P.J.2    Huxtable, S.J.3
  • 35
    • 0030803678 scopus 로고    scopus 로고
    • The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts
    • Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB. (1997) The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J. Biol. Chem. 272: 25433-25436.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25433-25436
    • Solanes, G.1    Vidal-Puig, A.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 36
    • 0344182443 scopus 로고    scopus 로고
    • Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells
    • Hinz W, Gruninger S, De PA, Chiesi M. (1999) Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells. FEES Lett. 462: 411-415.
    • (1999) FEES Lett. , vol.462 , pp. 411-415
    • Hinz, W.1    Gruninger, S.2    De, P.A.3    Chiesi, M.4
  • 37
    • 0032973459 scopus 로고    scopus 로고
    • Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system
    • Hagen T, Zhang C, Slicker L, Chung W, Leibel R, Lowell B. (1999) Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system. FEBS Lett. 454: 201-206.
    • (1999) FEBS Lett. , vol.454 , pp. 201-206
    • Hagen, T.1    Zhang, C.2    Slicker, L.3    Chung, W.4    Leibel, R.5    Lowell, B.6
  • 38
    • 0026794668 scopus 로고
    • The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences
    • Krawczak M, Reiss J, Cooper DN. (1992) The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences. Hum. Genet. 90: 41-54.
    • (1992) Hum. Genet. , vol.90 , pp. 41-54
    • Krawczak, M.1    Reiss, J.2    Cooper, D.N.3
  • 39
    • 0033382027 scopus 로고    scopus 로고
    • Endogenous mutations in human uncoupling protein 3 alter its functional properties
    • Brown A, Dolan J, Willi S, Garvey W, Argyropoulos G. (1999) Endogenous mutations in human uncoupling protein 3 alter its functional properties. FEBS Lett. 464: 189-193.
    • (1999) FEBS Lett. , vol.464 , pp. 189-193
    • Brown, A.1    Dolan, J.2    Willi, S.3    Garvey, W.4    Argyropoulos, G.5
  • 40
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • Skulachev VP. (1998) Uncoupling: new approaches to an old problem of bioenergetics, Biochim. Biopltys. Acta 1363: 100-124.
    • (1998) Biochim. Biopltys. Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 41
    • 0025109784 scopus 로고
    • Low ratio of fat to carbohydrate oxidation as predicator of weight gain: Study of 24-h RQ
    • Zurlo F, Lillioja S, Esposito-Del Puente A, et al. (1990) Low ratio of fat to carbohydrate oxidation as predicator of weight gain: study of 24-h RQ. Am. J. Physiol. 259: E650-E657.
    • (1990) Am. J. Physiol. , vol.259
    • Zurlo, F.1    Lillioja, S.2    Esposito-Del Puente, A.3


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