Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia

Anticancer Research

Volumn 16, Issue 6 B, 1996, Pages 3459-3466

  Berggren, Margareta ^a   Gallegos, Alfred ^a   Gasdaska, John R ^a   Gasdaska, Pamela Y ^a   Warneke, James ^b   Powis, Garth ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cell growth; Hypoxia; Thioredoxin; Thioredoxin reductase

Indexed keywords

MESSENGER RNA; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ARTICLE; BREAST CANCER; CANCER GROWTH; CELL PROLIFERATION; CELL TRANSFORMATION; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; SOLID TUMOR; TIME; TUMOR CELL LINE;

CELL HYPOXIA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; RNA, MESSENGER; THIOREDOXIN; THIOREDOXIN REDUCTASE (NADPH); TUMOR CELLS, CULTURED;

EID: 0030499036     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Holmgren A: Thioredoxin and glutaredoxin systems. J Biol Chem 264: 13963-13966, 1989.
2. Luthman M and Holmgren A: Rat liver thioredoxin and thioredoxin reductase: purification and characterization. Biochem 21: 6628-6633, 1982.
3. Derman AI, Prinz WA, Belin D and Beckwith J: Mutations that allow disulfide bond formation in the cytoplasm of Escherichia coli. Science 262: 1744-1747, 1993.
4. Laurent TC, Moore EC and Reichard P: Enzymatic synthesis of deoxyribonucleotides VI. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia coli B. J Biol Chem 239: 3436-3444, 1964.
5. Matthews JR, Wakasugi N, Virelizier J-L, Yodoi J and Hay RT: Thioredoxin regulates the DNA binding activity of NF-KB by reduction of it disulphide bond involving cysteine 62. Nucl Acids Res 20: 3821-3830, 1992.
6. Cromlish JA and Roeder RG: Human transcription factor IIIC (TFIIIC). Purification, polypeptide structure, and the involvement of thiol groups in specific DNA binding. J Biol Chem 264: 18100-18109, 1989.
7. Bannister AJ, Cook A and Kouzarides T: In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes. Oncogene 6: 1243-1250, 1991.
8. Grippo JF, Tienrungroj W, Dahmer MK, Housley PR and Pratt WB: Evidence that the endogenous heat-stable glucocorticoid receptoractivating factor is thioredoxin. J Biol Chem 258: 13658-13664, 1983.
9. Abate C, Patel L, Rauscher III FJ and Curran T: Redox regulation of fos and jun DNA-binding activity in vitro. Science 249: 1157-1161, 1990.
10. Yodoi J and Tursz T: ADF, a growth-promoting factor dervied from adult T cell leukemia and homologous to thioredoxin: Involvement in lymphocyte immortalization by HTLV-1 and EBV. Adv Cancer Res 57: 381-411, 1991.
11. Wakasugi N, Tagaya Y, Wakasugi A, Mitsui M, Maeda M, Yodoi J and Tursz T: Adult T-cell leukemia-derived factor/Thioredoxin produced by both human T-lymphotropic virus type 1 and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergized with interleukin-1 and interleukin-2. Proc Natl Acad Sci USA 87: 8282-8286, 1990.
12. Oblong JE, Berggren M, Gasdaska PY and Powis G: Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin. J Biol Chem 269: 11714-11720, 1994.
13. Ericson ML, Horling J, Wendel-Hansen V, Holmgren A and Rosen A: Secretion of thioredoxin after in vitio activation of human B cells. Lymphokine Cytokine Res 11: 201-207, 1992.
14. Rubartelli A, Bajetto A, Allavena G, Wollman E and Sitia R: Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J Biol Chem 267: 24161-24164, 1992.
15. Rubartelli A, Bonifaci N and Sitia R: High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells. Cancer Res 55: 675-680, 1995.
16. Gasdaska JR, Berggren M and Powis G: Cell growth stimulation by the redox prolein thioredoxin occurs by a novel helper mechanism. Cell Growth Differ 6: 1643-1650, 1995.
17. Gasdaska PY, Oblong JE, Cotgreave IA and Powis G: The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): Thioredoxin mRNA is elevated in some human tumors. Biochim Biophys Acta 1218: 292-296, 1994.
18. Nakamura H, Masutani H, Tagaya Y, Yamauchi A, Inamoto T, Nanbu Y, Fujii S, Ozawa K and Yodoi J: Expression and growth-promoting effect of adult T-cell leukemia-derived factor. A human thioredoxin homologue in hepatocellular carcinoma. Cancer 69: 2091-2097, 1992.
19. Fujii S, Nanbu Y, Nonogaki H, Konishi I, Mori T, Masutani H and Yodoi J: Coexpression of adult T-cell leukemia-derived factor, a human thioredoxin homologue, and human papillomavirus DNA in neoplastic cervical squamous epithelium. Cancer 68: 1583-1591, 1991.
20. Gallegos A, Gasdaska JR, Goodman D, Gasdaska PY, Berggren M, Briehl MM and Powis G: Transfection with human thioredoxin increases cell proliferation and a dominant negative mutant thioredoxin reverses the transformed phenotype of breast cancer cells. Cancer Res 1996.(in press)
21. Gasdaska PY, Gasdaska JR, Cochran S and Powis G: Cloning and sequencing of human thioredoxin reductase. FEBS Lett 373: 5-9, 1995.
22. Briehl MM, Cotgreave IA and Powis G: Downregulation of the antioxidant defense during glucocorticoid-mediated apoptosis. Cell Death Differ 2: 41-46, 1995.
23. Grever MR, Schepartz SA and Chabner BA: The National Cancer Institute: cancer drug discovery and development program. Semin Oncol 19: 622-638, 1992.
24. Laborda J: 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucl Acids Res 19: 3998, 1991.
25. Holmgren A: Bovine thioredoxin system: Purification of thioredoxin reductase from calf liver and thymus and studies of its function in dissultide reduction. J Biol Chem 252: 4600-4606, 1977.
26. Mau B-L and Powis G: Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin. Biochem Pharmacol 43: 1621-1626, 1992.
27. Yao K-S, Xanthoudakis S, Curran T and O'Dwyer PJ: Activation of AP-1 and of a nuclear redox factor, ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol 14: 5997-6003, 1994.
28. Dangou JM, KiSS R, DePrez C, Jeannot MC, Fastrez R, Pasteels JL and Verhest A: Heterogeneity of DNA ploidy. proliferation index and nuclear size in human colorectal carcinomas. Anal & Quant Cytol & Histol 15: 23-31, 1993.
29. Rockwell S: Use of hypoxia-directed drugs in the therapy of solid tumors. Semin Oncol 14 (4 supp. 11): 29-40, 1992.
30. Kaghad M, Dessarps F, Jacquemin-Sablon H, Caput D, Fradelizi D and Wollman EE: Genomic cloning of human thioredoxin-encoding gene: mapping of the transcription start point and analysis of the promoter. Gene 140: 273-278, 1994.
31. Tonissen KF and Wells JRE: Isolation and characterization of human thioredoxin-encoding genes. Gene 702:221-228, 1991.
32. Wollman EE, d'Auriol L, Rimsky L, Shaw A, Jacquot J-P, Wingfield P, Graber P, Dessarps F, Robin P, Galibert F, Bertoglio J and Fradelizi D: Cloning and expression of cDNA for human thioredoxin. J Biol Chem 263: 15506-15512, 1988, 21
33. An G and Wu R: Thioredoxin gene expression is transcriptionally up-regulated by retinol in monkey conducting airway epithelial cells. Biochem Biophys Res Commun 183: 170-175, 1992.
34. Schallreuter KU and Wood JM: The role of thioredoxin reductase in the reduction of tree radicals at the surface of the epidermis. Biochem Biophys Res Commun 136: 630-637, 1986.
35. Hayashi T, Ueno Y and Okamoto T: Oxidoreductive regulation of nuclear factor KB. J Biol Chem 268: 11380-11388, 1993.
36. Rozell B, Hansson HA, Luthman M and Holmgren A: Immunohistochemical localization of thioredoxin and thioredoxin reductase in adult rats. Eur J Cell Biol 38: 79-86, 1985.