Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and Suppress T cell activation

Molecular Pharmacology

Volumn 50, Issue 6, 1996, Pages 1672-1679

  Nguyen, Angela ^a   Kath, John C ^c   Hanson, Douglas C ^c   Biggers, Michael S ^c   Canniff, Paul C ^c   Donovan, Carol B ^c   Mather, Robert J ^c   Bruns, Mathew J ^c   Rauer, Heiko ^d   Aiyar, Jayashree ^a   Lepple Wienhues, Albrecht ^a   Gutman, George A ^b   Grissmer, Stephan ^d   Cahalan, Michael D ^a   Chandy, K George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 1,4 DIHYDRO 4 PENTYLIMINOQUINOLINE; BENZYLISOQUINOLINE DERIVATIVE; CHARYBDOTOXIN; CP 393223; CP 393224; CP 394322; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; WIN 17317 3;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; IMMUNE SYSTEM; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

HELA CELLS; HUMANS; LYMPHOCYTE ACTIVATION; MUTATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROTEIN CONFORMATION; SHAL POTASSIUM CHANNELS; T-LYMPHOCYTES;

EID: 8044255249     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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