Peptidyl inhibitors of Shaker-type K(v)1 channels elicit twitches in guinea pig ileum by blocking k(v)1.1 at Enteric nervous system and enhancing acetylcholine release

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 3, 1999, Pages 1517-1522

  Suarez Kurtz, Guilherme ^a,c   Vianna Jorge, Rosane ^a   Pereira, Bianca F ^a   Garcia, Maria Luisa ^b   Kaczorowski, Gregory J ^b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b MERCK RESEARCH LABORATORIES   (United States)

^c INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ATROPINE; CALCIUM; HEXAMETHONIUM; KALIOTOXIN; MARGATOXIN; NIFEDIPINE; POTASSIUM CHANNEL; TETRODOTOXIN;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DETRUSOR MUSCLE; GUINEA PIG; ILEUM; INTESTINE INNERVATION; INTESTINE MOTILITY; MUSCLE ACTION POTENTIAL; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ANIMALS; ATROPINE; ENTERIC NERVOUS SYSTEM; FEMALE; GUINEA PIGS; HEXAMETHONIUM; ILEUM; ISOMETRIC CONTRACTION; KV1.1 POTASSIUM CHANNEL; MALE; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; NEUROTOXINS; NIFEDIPINE; PEPTIDES; PORTAL VEIN; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, WISTAR; SCORPION VENOMS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; TETRODOTOXIN; TOXINS, BIOLOGICAL; URINARY BLADDER;

EID: 0032992841     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. + channels characterized from Androctonus mauretanicus venom. J Biol Chem 267:1640-1647.
2. Christie MJ, Adelman JP, Douglas J and North RA (1989) Expression of a cloned rat brain potassium channel in Xenopus oocytes. Science (Wash DC) 144:221-224.
3. + channel blockers paspalitrem-C and paxilline on mammalian smooth muscle. Eur J Pharmacol 314:123-128.
4. Dufton MJ and Harvey AL (1998) Dendrotoxins: How does structure determine function? J Toxicol 17:161-182.
5. Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski GJ and Garcia ML (1990) Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem 265:11083-11090.
6. + channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry 33:6834-6839.
7. Garcia ML, Hanner M, Knaus H-G, Koch R, Schmalhofer W, Slaughter RS and Kaczorowski GJ (1997) Pharmacology of potassium channels. Adv Pharmacol 39:425-471.
8. Garcia-Calvo M, Leonard RJ, Novick J, Steven SP, Schmalhofer W, Kaczorowski GJ and Garcia ML (1993) Purification, characterization, and bio-synthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J Biol Chem 268:18866-18874.
9. Gimenez-Gallego G, Navia MA, Reuben JP, Katz GM, Kaczorowski GJ and Garcia ML (1988) Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci USA 85:3329-3333.
10. v1.3 expressed in CHO cells. Biochemistry 36:3737-3744.
11. + channels in Aplysia neurons. J Gen Physiol 91:17-47.
12. v1.3-specific immunosuppressive polypeptide. J Biol Chem 273:32697-32707
13. [125]I-Margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain. Biochemistry 34:13627-13634.
14. + channels. J Biol Chem 272:27577-27581.
15. v1.3 inhibits immune responses in vivo. J Immunol 158:5120-5128.
16. Koschak A, Bugianesi RM, Mitterdorfer J, Kaczorowski GJ, Garcia ML and Knaus H-G (1998) Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem 273:2639-2644.
17. + channels depolarize human lymphocytes. Mechanism of the antiproliferative effect of charybdotoxin. Proc Natl Acad Sci USA 89:10094-10098.
18. + channels from skeletal muscle. Nature (Lond) 313:316-318.
19. + channels in human and murine T-lymphocytes. J Gen Physiol 93:1061-1074.
20. Suarez-Kurtz G, Garcia ML and Kaczorowski GJ (1991) Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. J Pharmacol Exp Ther 259:439-443.
21. Winquist RJ, Heaney LA, Wallace AA, Baskin EP, Stein RG, Garcia ML and Kaczorowski GJ (1989) Glyburide blocks the relaxation response to BRL-34915 (cromakalim), minoxidil sulphate and diazoxide in vascular smooth muscle. J Pharmacol Exp Ther 248:149-156.