EB1 targets to kinetochores with attached, polymerizing microtubules

Molecular Biology of the Cell

Volumn 13, Issue 12, 2002, Pages 4308-4316

  Tirnauer, Jennifer S ^a   Canman, Julie C ^b   Salmon, E D ^b,c   Mitchison, Timothy J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; NOCODAZOLE; PROTEIN; PROTEIN EB1; UNCLASSIFIED DRUG; EB1 MICROTUBULE BINDING PROTEINS; MICROTUBULE ASSOCIATED PROTEIN;

ANAPHASE; ANEUPLOIDY; ARTICLE; CENTROMERE; CONTROLLED STUDY; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN POLYMERIZATION; CELL NUCLEUS; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MOLECULAR CLONING;

CELL NUCLEUS; CLONING, MOLECULAR; DYNEIN ATPASE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; KINETOCHORES; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; PROTEIN BINDING;

EID: 1842854468     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E02-04-0236     Document Type: Article

References (41)

1. Askham, J.M., Moncur, P., Markham, A.F., and Morrison, E.E. (2000). Regulation, and function of the interaction between the APC tumor suppressor protein, and EB1. Oncogene 19, 1950-1958.
2. Beinhauer, J.D., Hagan, I.M., Hegemann, J.H., and Fleig, U. (1997). Mal3, the fission yeast homolog of the human APC-interacting protein EB-1, is required for microtubule integrity and the maintenance of cell form. J. Cell Biol. 139, 717-728.
3. Berrueta, L., Kraeft, S.-K., Tirnauer, J.S., Schuyler, S., Chen, L.B., Hill, D.E., Pellman, D., and Bierer, B. (1998). The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Proc. Natl. Acad. Sci. USA 95, 10596-10601.
4. Berrueta, L., Tirnauer, J.S., Schuyler, S.C., Pellman, D., and Bierer, B.E. (1999). The APC-associated ptotein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. Curr. Biol. 9, 425-428.
5. Canman, J.C., Hoffman, D.B., and Salmon, E.D. (2000). The role of pre- and post-anaphase microtubules in the cytokinesis phase of the cell cycle. Curr. Biol. 10, 611-614.
6. Coquelle, F.M., et al. (2002). Lis1, CLIP-170's key to the dynein/dynactin pathway. Mol. Cell. Biol. 22, 3089-3102.
7. Dujardin, D., Wacker, U.I., Moreau, A., Schroer, T.A., Rickard, J.E., and De Mey, J.R. (1998). Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment. J. Cell Biol. 141, 849-862.
8. Echeverri, C.J., Paschal, B.M., Vaughan, K.T., and Vallee, R.B. (1996). Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132, 617-633.
9. Faulkner, N.E., Dujardin, D.L., Tai, C.-Y., Vaughan, K.T., O'Connell, C.B., Wang, Y.-L., and Vallee, R.B. (2000). A role for the lissencephaly gene L1S1 in mitosis and cytoplasmic dynein function. Nat. Cell Biol. 2, 784-791.
10. Fodde, R., et al. (2001). Mutations in the APC tumor suppressor gene cause chromosomal instability. Nat. Cell Biol. 3, 433-438.
11. Hoffman, D.B., Pearson, C.G., Yen, T.J., Howell, B.J., and Salmon, E.D. (2001). Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol. Biol. Cell 12, 1995-2009.
12. Howell, B.J., McEwen, B.F., Canman, J.C., Hoffman, D.B., Farrar, E.M., Rieder, C.L., and Salmon, E.D. (2001). Cytoplasmic dynein/dynactin drives kinctochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J. Cell Biol. 155, 1159-1172.
13. Hyman, A.A., and Mitchison, T.J. (1990). Modulation of microtubule stability by kinetochores in vitro. J. Cell Biol. 110, 1607-1616,
14. Kaplan, K.B., Burds, A.A., Swedlow, J.R., Bekir, S.S., Sorger, P.K., and Nathke, I.S. (2001). A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3, 429-432.
15. Khodjakov, A., and Rieder, C.L. (1996). Kinetochores moving away from their associated pole do not exert a significant pushing force on the chromosome. J. Cell Biol. 135, 315-327.
16. Korinek, W.S., Copeland, M.J., Chaudhuri, A., and Chant, J. (2000). Molecular linkage underlying microtubule orientation toward cortical sites in yeast. Science 287, 2257-2259.
17. Lee, L., Tirnauer, J.S., Li, J., Schuyler, S.C., Liu, J.Y., and Pellman, D. (2000). Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. Science 287, 2260-2262.
18. Maney, T., Ginkel, L.M., Hunter, A.W., and Wordeman, L. (2000). The kinetochore of higher eukaryotes: A molecular view. Int. Rev. Cytol. 194, 67-131.
19. Mayer, T.U., Kapoor, T.M., Haggarty, S.J., King, R.W., Schreiber, S.L., and Mitchison, T.J. (1999). Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974.
20. McEwen, B.F., Chan, G.K., Zubrowski, B., Savoian, M.S., Sauer, M.T., and Yen, T.J. (2001). CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol. Biol. Cell 12, 2776-2789.
21. Miller, R.K., Cheng, S.-C., and Rose, M.D. (2000). Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules. Mol. Biol. Cell 11, 2949-2959.
22. Mimori-Kiyosue, Y., Shiina, N., and Tsukita, S. (2000a). Adenomatous polyposis coli (APC) protein moves along microtubules, and concentrates at their growing ends in epithelial cells. J. Cell Biol. 148, 505-517.
23. Mimori-Kiyosue, Y., Shiina, N., and Tsukita, S. (2000b). The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr. Biol. 10, 865-868.
24. Mimori-Kiyosue, Y., and Tsukita, S. (2001). Where is APC going? J. Cell Biol. 154, 1105-1109.
25. Mitchison, T.J, (1988). Microtubule dynamics and kinetochore function in mitosis. Annu. Rev. Cell Biol. 4, 527-549.
26. Mitchison, T.J. (1989). Polewards microtubule flux in the mitotic spindle: Evidence from photoactivation of fluorescence. J. Cell Biol. 109, 637-652.
27. Mitchison, T.J., and Kirschner, M.W. (1985). Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J. Cell Biol. 101, 766-777.
28. Morrison, E.E., Wardleworth, B.N., Askham, J.M., Markham, A.F., and Meredith, D.M. (1998). EB1, a protein which interacts with the APC tumor suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. Oncogene 17, 3471-3477.
29. Nakamura, M., Zhou, X.Z., and Lu, K.P. (2001). Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Curr. Biol. 11, 1062-1067.
30. Rattner, I.B., Rao, A., Fritzler, M.J., Valencia, D.W., and Yen, T.J. (1993). CENP-F is a ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Cell Motil. Cytoskeleton 26, 214-226.
31. Rieder, C.L., and Salmon, E.D. (1994). Motile kinctochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle. J. Cell Biol. 124, 223-233.
32. Rieder, C.L., and Salmon, E.D. (1998). The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol. 8, 310-318.
33. Rusan, N.M., Fagerstrom, C.J., Yvon, A.-M.C., and Wadsworth, P. (2001). Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-α tubulin. Mol. Biol. Cell 12, 971-980.
34. Schuyler, S., and Pellman, D. (2001). Microtubule "plus-end-tracking proteins": The end is just the beginning. Cell 105, 421-424.
35. Su, L.-K., Burrell, M., Hill, D.E., Gyuris, J., Brent, R., Wiltshire, R., Trent, J., Vogelstein, B., and Kinzler, K.W. (1995). APC binds to the novel protein EB1. Cancer Res. 55, 2972-2977.
36. Tai, C.-Y., Dujardin, D.L., Faulkner, N.E., and Vallee, R.B. (2002). Role of dynein, dynactin, and CLIP-170 interactions in Lis1 kinetochore function. J. Cell Biol. 156, 959-968.
37. Tirnauer, J.S., and Bierer, B.E. (2000). EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. J. Cell Biol. 149, 761-766.
38. Tirnauer, J.S., Grego, S., Salmon, E.D., and Mitchison, T.J. (2002). EB1-microtubule interactions in xenopus egg extracts: Role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol. Biol. Cell 13, 3614-3626.
39. Tirnauer, J.S., O'Toole, E., Berrueta, L., Bierer, B., and Pellman, D. (1999). Yeast Bim1p promotes the G1-specific dynamics of microtubules. J. Cell Biol. 145, 993-1007.
40. Wittmann, T., and Hyman, T. (1999). Recombinant p50/dynamitin as a tool to examine the role of dynactin in intracellular processes. Methods Cell Biol. 61, 137-143.
41. Zhai, Y., Kronebusch, P.J., and Borisy, G.G. (1995). Kinetochore microtubule dynamics at the metaphase-anaphase transition. J. Cell Biol. 131, 721-734.