Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function

Journal of Cell Biology

Volumn 156, Issue 6, 2002, Pages 959-968

  Tai, Chin Yin ^a   Dujardin, Denis L ^b   Faulkner, Nicole E ^b   Vallee, Richard B ^b,c  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Department of Pathology ^*  (United States)

^c Genzyme   (United States)

Author keywords

CLIP 170; Dynactin; Dynein; Kinetochores; LIS1

Indexed keywords

DYNACTIN; DYNAMITIN; DYNEIN ADENOSINE TRIPHOSPHATASE; GENE PRODUCT; PROTEIN CLIP 170; UNCLASSIFIED DRUG;

AGYRIA; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN DEVELOPMENT; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CENTROMERE; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOPRECIPITATION; MITOSIS; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TWO HYBRID SYSTEM;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ANIMALS; COS CELLS; DYNEIN ATPASE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; KINETOCHORES; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MOLECULAR MOTOR PROTEINS; MUTATION; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; TRINUCLEOTIDE REPEATS;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0037128930     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109046     Document Type: Article

References (46)

1. Nudf, a fungal homolog of the human LIS1 protein, functions as a dimer in vivo
2. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution
3. The location and type of mutation predict malformation severity in isolated lissencephaly caused by abnormalities within the LIS1 gene
4. Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase
5. Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment
6. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis
7. The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein
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9. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
10. Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeleton
11. An extended microtubule-binding structure within the dynein motor domain
12. Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways
13. Vanadate-sensitized cleavage of dynein heavy chains by 365-nm irradiation of demembranated sperm flagella and its effect on the flagellar motility
14. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
15. Interaction mapping of a dynein heavy chain. Identification of dimerization and intermediate-chain binding domains
16. Purification and characterization of bovine brain platelet-activating factor acetylhydrolase
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19. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex
20. Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension
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32. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats
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37. ZW10 helps recruit dynactin and dynein to the kinetochore
38. Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development
39. Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport
40. Distinct but overlapping sites within the cytoplasmic dynein heavy chain for dimerization and for intermediate chain and light intermediate chain binding
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42. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued
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44. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
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46. The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane