Proliferation and differentiation in isogenic populations of peripheral B cells activated by Epstein-Barr virus or T cell-derived mitogens

Journal of General Virology

Volumn 85, Issue 4, 2004, Pages 881-895

  O'Nions, Jenny ^a   Allday, Martin J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CELL SURFACE MARKER; CYTOKINE; IMMUNOGLOBULIN; INTERLEUKIN 4; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TRYPAN BLUE;

B LYMPHOCYTE DIFFERENTIATION; BLAST CELL; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL ISOLATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LYMPHOBLASTOID CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MITOGENICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STAINING; T LYMPHOCYTE; WESTERN BLOTTING;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTE SUBSETS; CD40 LIGAND; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CYTOKINES; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULINS; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MITOGENS; PLASMA CELLS; T-LYMPHOCYTES;

HUMAN HERPESVIRUS 4;

EID: 1842843170     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.19704-0     Document Type: Review

References (78)

1. Agematsu, K. (2000). Memory B cells and CD27. Histol Histopathol 15, 573-576.
2. Allday, M. J., Sinclair, A., Parker, G., Crawford, D. H. & Farrell, P. J. (1995). Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53. EMBO J 14, 1382-1391.
3. Altmeyer, A., Simmons, R. C., Krajewski, S., Reed, J. C., Bornkamm, G. W. & Chen-Kiang, S. (1997). Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation. Immunity 7, 667-677.
4. Aman, P., Ehlin-Henriksson, B. & Klein, G. (1984). Epstein-Barr virus susceptibility of normal human B lymphocyte populations. J Exp Med 159, 208-220.
5. Armitage, R. J., Fanslow, W. C., Strockbine, L. & other authors (1992). Molecular and biological characterization of a murine ligand for CD40. Nature 357, 80-82.
6. Arpin, C., Dechanet, J., Van Kooten, C., Merville, P., Grouard, G., Briere, F., Banchereau, J. & Liu, Y. J. (1995). Generation of memory B cells and plasma cells in vitro. Science 268, 720-722.
7. Banchereau, J. & Rousset, F. (1991). Growing human B lymphocytes in the CD40 system. Nature 353, 678-679.
8. Banchereau, J., de Paoli, P., Valle, A., Garcia, E. & Rousset, F. (1991). Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 251, 70-72.
9. Burdin, N., Van Kooten, C., Galibert, L., Abrams, J. S., Wijdenes, J., Banchereau, J. & Rousset, F. (1995). Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J Immunol 154, 2533-2544.
10. Burdin, N., Rousset, F. & Banchereau, J. (1997). B-cell-derived IL-10: production and function. Methods Enzymol 11, 98-111.
11. Caldwell, R. G., Wilson, J. B., Anderson, S. J. & Longnecker, R. (1998). Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 9, 405-411.
12. Caldwell, R. G., Brown, R. C. & Longnecker, R. (2000). Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice. J Virol 74, 1101-1113.
13. Callard, R. E., Herbert, J., Smith, S. H., Armitage, R. J. & Costelloe, K. E. (1995). CD40 cross-linking inhibits specific antibody production by human B cells. Int Immunol 11, 1809-1815.
14. Campisi, J. (2003). Cancer and ageing: rival demons? Nat Rev Cancer 3, 339-349.
15. Cannell, E. J., Farrell, P. J. & Sinclair, A. J. (1996). Epstein-Barr virus exploits the normal cell pathway to regulate Rb activity during the immortalisation of primary B-cells. Oncogene 13, 1413-1421.
16. Casamayor-Palleja, M., Khan, M. & MacLennan, I. C. (1995). A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J Exp Med 181, 1293-1301.
17. Chen-Kiang, S. (1995). Regulation of terminal differentiation of human B-cells by IL-6. Curr Top Microbiol Immunol 194, 189-198.
18. Waf1/Cip1 protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J 22, 2036-2046.
19. Crawford, D. H. (1986). Use of the virus to prepare human-derived monoclonal antibodies. In The Epstein-Barr Virus: Recent Advances, pp. 249-271. Edited by M. A. Epstein & B. G. Achong. London: William Heinemann Medical Books.
20. Croft, M. & Swain, S. L. (1991). B cell response to fresh and effector T helper cells. Role of cognate T-B interaction and the cytokines IL-2, IL-4, and IL-6. J Immunol 146, 4055-4064.
21. Ehlin-Henriksson, B., Gordon, J. & Klein, G. (2003). B-lymphocyte subpopulations are equally susceptible to Epstein-Barr virus infection, irrespective of immunoglobulin isotype expression. Immunology 108, 427-430.
22. Finke, J., Rowe, M., Kallin, B., Ernberg, I., Rosen, A., Dillner, J. & Klein, G. (1987). Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell lines. J Virol 61, 3870-3878.
23. Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 12, 2899-2911.
24. Fukuda, M., Satoh, T. A., Takanashi, M., Hirai, K., Ohnishi, E. & Sairenji, T. (2000). Inhibition of cell growth and Epstein-Barr virus reactivation by CD40 stimulation in Epstein-Barr virus-transformed B cells. Viral Immunol 13, 215-229.
25. Garrone, P., Neidhardt, E. M., Garcia, E., Galibert, L., van Kooten, C. & Banchereau, J. (1995). Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J Exp Med 182, 1265-1273.
26. Gires, O., Zimber-Strobl, U., Gonnella, R., Ueffing, M., Marschall, G., Zeidler, R., Pich, D. & Hammerschmidt, W. (1997). Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J 16, 6131-6140.
27. Gordon, J. & Pound, J. D. (2000). Fortifying B cells with CD154: an engaging tale of many hues. Immunology 100, 269-280.
28. Greipp, P. R., Witzig, T. E. & Gonchoroff, N. J. (1985). Immunofluorescent plasma cell labeling indices (LI) using a monoclonal antibody (BU-1). Am J Hematol 20, 289-292.
29. Harada, H., Kawano, M. M., Huang, N. & 7 other authors (1993). Phenotypic difference of normal plasma cells from mature myeloma cells. Blood 81, 2658-2663.
30. Henle, W., Diehl, V., Kohn, G., Zur Hausen, H. & Henle, G. (1967). Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science 157, 1064-1065.
31. Janeway, C. A., Travers, P., Walport, M. & Shlomchik, M. J. (2001). Immunobiology: the immune system in health and disease, 5th edn. New York: Garland Publishing.
32. Jego, G., Bataille, R. & Pellat-Deceunynck, C. (2001). Interleukin-6 is a growth factor for nonmalignant human plasmablasts. Blood 97, 1817-1822.
33. Jung, D., Neron, S., Lemieux, R., Roy, A. & Richard, M. (2001). Telomere-independent reduction of human B lymphocyte: proliferation during long-term culture. Immunol Invest 30, 157-168.
34. Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F. & Sherr, C. J. (1998). Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A 95, 8292-8297.
35. Kataoka, H., Tahara, H., Watanabe, T., Sugawara, M., Ide, T., Goto, M., Furuichi, Y. & Sugimoto, M. (1997). Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity. Differentiation 62, 203-211.
36. Kieff, E. & Rickinson, A. B. (2001). Epstein Barr Virus and its replication. In Fields Virology, 4th dn, pp. 2511-2574. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins.
37. Klein, U., Küppers, R. & Rajewsky, K. (1997). Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 89, 1288-1298.
38. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 188, 1679-1689.
39. Lam, E. W., Glassford, J., van der Sman, J., Banerji, L., Pizzey, A. R., Shaun, N., Thomas, B. & Klaus, G. G. (1999). Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors. Eur J Immunol 29, 3380-3389.
40. Lam, E. W., Glassford, J., Banerji, L., Thomas, N. S., Sicinski, P. & Klaus, G. G. (2000). Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J Biol Chem 275, 3479-3484.
41. Lane, P., Traunecker, A., Hubele, S., Inui, S., Lanzavecchia, A. & Gray, D. (1992). Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J Immunol 22, 2573-2578.
42. Lohoff, M., Koch, A. & Rollinghoff, M. (1992). Two signals are involved in polyclonal B cell stimulation by T helper type 2 cells: a role for LFA-1 molecules and interleukin 4. Eur J Immunol 22, 599-602.
43. Mathon, N. F. & Lloyd, A. C. (2001). Cell senescence and cancer. Nat Rev Cancer 1, 203-213.
44. McCloskey, N., Pound, J. D., Holder, M. J., Williams, J. M., Roberts, L. M., Lord, J. M. & Gordon, J. (1999). The extrafollicular-to-follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40. Eur J Immunol 29, 3236-3244.
45. INK4c and IL-6. Immunity 6, 47-56.
46. Nakagomi, H., Dolcetti, R., Bejarano, M. T., Pisa, P., Kiessling, R. & Masucci, M. G. (1994). The Epstein-Barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in Burkitt lymphoma lines. Int J Cancer 57, 240-244.
47. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. & Riccardi, C. (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139, 271-279.
48. Nilsson, K. (1979). The nature of lymphoid cell lines and their relationship to the virus. In The Epstein-Barr Virus, pp. 225-281. Edited by M. A. Epstein & B. G. Achong. Berlin: Springer.
49. Nilsson, K. & Ponten, J. (1975). Classification and biological nature of established human hematopoietic cell lines. Int J Cancer 15, 321-341.
50. Nilsson, K., Klein, G., Henle, W. & Henle, G. (1971). The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV. Int J Cancer 8, 443-450.
51. Noelle, R. J., Roy, M., Shepherd, D. M., Stamenkovic, I., Ledbetter, J. A. & Aruffo, A. (1992). A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci U S A 89, 6550-6554.
52. O'Nions, J. & Allday, M. J. (2003). Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2. Oncogene 22, 7181-7191.
53. Ormerod, M. G., Sun, X. M., Snowden, R. T., Davies, R., Fearnhead, H. & Cohen, G. M. (1993). Increased membrane permeability of apoptotic thymocytes: a flow cytometric study. Cytometry 14, 595-602.
54. Parker, S. B., Eichele, G., Zhang, P., Rawls, A., Sands, A. T., Bradley, A., Olson, E. N., Harper, J. W. & Elledge, S. J. (1995). p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267, 1024-1027.
55. Parker, G. A., Crook, T., Bain, M., Sara, E. A., Farrell, P. J. & Allday, M. J. (1996). Epstein-Barr virus nuclear antigen (EBNA 3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7. Oncogene 13, 2541-2549.
56. Pokrovskaja, K., Ehlin-Henriksson, B., Kiss, C., Challa, A., Gordon, J., Gogolak, P., Klein, G. & Szekely, L. (2002). CD40 ligation down-regulates EBNA-2 and LMP-1 expression in EBV-transformed lymphoblastoid cell lines. Int J Cancer 99, 705-712.
57. Polack, A., Hortnagel, K., Pajic, A. & 7 other authors (1996). c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. Proc Natl Acad Sci U S A 93, 10411-10416.
58. Pope, J. H. (1967). Establishment of cell lines from peripheral leucocytes in infectious mononucleosis. Nature 216, 810-811.
59. Quelle, D. E., Zindy, F., Ashmun, R. A. & Sherr, C. J. (1995). Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-1000.
60. Randall, T. D., Heath, A. W., Santos-Argumedo, L., Howard, M. C., Weissman, I. L. & Lund, F. E. (1998). Arrest of B lymphocyte terminal differentiation by CD40 signalling: mechanism for lack of antibody-secreting cells in germinal centres. Immunity 8, 733-742.
61. Richards, M. L. & Katz, D. H. (1997). Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter. J Immunol 158, 263-272.
62. Rousset, F., Peyrol, S., Garcia, E., Vezzio, N., Andujar, M., Grimaud, J. A. & Banchereau, J. (1995). Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4. Int Immunol 7, 1243-1253.
63. Schonbeck, U. & Libby, P. (2001). The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci 58, 4-43.
64. kip1 cyclin-dependent kinase inhibitors is regulated differently during human B cell differentiation. J Immunol 165, 4346-4352.
65. Sherr, C. J. & DePinho, R. A. (2000). Cellular senescence: mitotic clock or culture shock? Cell 102, 407-410.
66. ARF-p53 signaling. Genes Dev 16, 681-686.
67. Smeland, E. B., Blomhoff, H. K., Funderud, S., Shalaby, M. R. & Espevik, T. (1989). Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes. J Exp Med 170, 1463-1468.
68. Spender, L. C., Cannell, E. J., Hollyoake, M., Wensing, B., Gawn, J. M., Brimmell, M., Packham, G. & Farrell, P. J. (1999). Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus. J Virol 73, 4678-4688.
69. Staudt, L. M. & Brown, P. O. (2000). Genomic views of the immune system. Annu Rev Immunol 18, 829-859.
70. Thorley-Lawson, D. A. (2001). Epstein-Barr virus: exploiting the immune system. Nat Rev Immunol 1, 75-82.
71. Tosato, G., Tanner, J., Jones, K. D., Revel, M. & Pike, S. E. (1990). Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized B cells. J Virol 64, 3033-3041.
72. INK4c is required for the generation of functional plasma cells. Immunity 17, 179-189.
73. Urashima, M., Chauhan, D., Hatziyanni, M., Ogata, A., Hollenbaugh, D., Aruffo, A. & Anderson, K. C. (1996). CD40 ligand triggers interleukin-6 mediated B cell differentiation. Leuk Res 20, 507-515.
74. van Kooten, C. & Banchereau, J. (2000). CD40-CD40 ligand. J Leukoc Biol 67, 2-17.
75. Vousden, K. H. & Lu, X. (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2, 594-604.
76. 2/M checkpoint activated by genotoxins. Mol Cell Biol 20, 1344-1360.
77. Walker, P. R., Smith, C., Youdale, T., Leblanc, J., Whitfield, J. F. & Sikorska, M. (1991). Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res 51, 1078-1085.
78. Worm, M., Krah, J. M., Manz, R. A. & Henz, B. M. (1998). Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro. Blood 92, 1713-1720.